{"id":2400,"date":"2026-09-27T11:45:07","date_gmt":"2026-09-27T04:45:07","guid":{"rendered":"https:\/\/cpc1.vn\/kaolin\/"},"modified":"2026-09-27T11:45:07","modified_gmt":"2026-09-27T04:45:07","slug":"kaolin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/kaolin\/","title":{"rendered":"Kaolin (cao lanh, E559) \u2013 ch\u1ea5t h\u1ea5p ph\u1ee5, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, b\u1ed9t r\u1eafc"},"content":{"rendered":"

Kaolin (cao lanh, E559) \u2013 ch\u1ea5t h\u1ea5p ph\u1ee5, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, b\u1ed9t r\u1eafc<\/h1>\n

Kaolin<\/strong> (cao lanh, China clay, E559) l\u00e0 nh\u00f4m silicat ng\u1eadm n\u01b0\u1edbc t\u1ef1 nhi\u00ean, \u0111\u01b0\u1ee3c nghi\u1ec1n v\u00e0 lo\u1ea1i h\u1ea1t s\u1ea1n b\u1eb1ng g\u1ea1n l\u1eafng. Trong b\u00e0o ch\u1ebf, kaolin t\u1eebng \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n, vi\u00ean nang, ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch v\u00e0 \u2013 \u1edf d\u1ea1ng ti\u1ec7t khu\u1ea9n \u2013 l\u00e0m cao \u0111\u1eafp, b\u1ed9t r\u1eafc ngo\u00e0i da. Ng\u00e0y nay kaolin ph\u1ea7n l\u1edbn \u0111\u01b0\u1ee3c xem l\u00e0 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n “c\u1ed5 \u0111i\u1ec3n”.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nChina clay, kaolinite, argilla, bolus alba, white bole, porcelain clay, E559<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n1332-58-7<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c<\/td>\nAl2<\/sub>O3<\/sub>\u00b72SiO2<\/sub>\u00b72H2<\/sub>O (Al2<\/sub>H4<\/sub>O9<\/sub>Si2<\/sub>) \u2013 258,16<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t h\u1ea5p ph\u1ee5, ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

BP ph\u00e2n bi\u1ec7t kaolin nh\u1eb9 (c\u00f3 ch\u1ea5t ph\u00e2n t\u00e1n), kaolin nh\u1eb9 t\u1ef1 nhi\u00ean (kh\u00f4ng ch\u1ea5t ph\u00e2n t\u00e1n) v\u00e0 kaolin n\u1eb7ng (Ph.Eur. \u2013 nh\u00f4m silicat ng\u1eadm n\u01b0\u1edbc tinh ch\u1ebf, th\u00e0nh ph\u1ea7n thay \u0111\u1ed5i).<\/p>\n

Applications<\/h2>\n
    \n
  • Thu\u1ed1c u\u1ed1ng: t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n, vi\u00ean nang; ch\u1ea5t d\u1eabn t\u1ea1o h\u1ed7n d\u1ecbch.<\/li>\n
  • D\u00f9ng ngo\u00e0i: kaolin ti\u1ec7t khu\u1ea9n l\u00e0m cao \u0111\u1eafp (poultice), b\u1ed9t r\u1eafc.<\/li>\n
  • Kaolin c\u00f2n l\u00e0 ho\u1ea1t ch\u1ea5t h\u1ea5p ph\u1ee5 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a trong m\u1ed9t s\u1ed1 ch\u1ebf ph\u1ea9m \u2013 n\u1ed9i dung l\u00e2m s\u00e0ng kh\u00f4ng tr\u00ecnh b\u00e0y \u1edf \u0111\u00e2y.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng \u0111\u1ebfn tr\u1eafng x\u00e1m, s\u1edd tr\u01a1n, kh\u00f4ng s\u1ea1n; v\u1ecb \u0111\u1ea5t s\u00e9t \u0111\u1eb7c tr\u01b0ng; khi \u1ea9m s\u1eabm m\u00e0u v\u00e0 c\u00f3 m\u00f9i \u0111\u1ea5t s\u00e9t.<\/li>\n
    • pH h\u1ed7n d\u1ecbch 20%: 4,0\u20137,5; t\u1ef7 tr\u1ecdng 2,6; chi\u1ebft su\u1ea5t 1,56; \u0111\u1ed9 c\u1ee9ng Mohs 2,0; \u0111\u1ed9 tr\u1eafng 85\u201390% so v\u1edbi MgO.<\/li>\n
    • C\u1ee1 h\u1ea1t trung v\u1ecb 0,6\u20130,8 \u00b5m.<\/li>\n
    • \u0110\u1ed9 \u1ea9m c\u00e2n b\u1eb1ng kho\u1ea3ng 1% \u1edf 15\u201365% RH; tr\u00ean kho\u1ea3ng 75% RH h\u00fat th\u00eam \u00edt \u1ea9m.<\/li>\n
    • H\u1ed7n d\u1ecbch 70% c\u00f3 \u0111\u1ed9 nh\u1edbt kho\u1ea3ng 300 mPa\u00b7s.<\/li>\n
    • H\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc, ethanol, ether, dung m\u00f4i h\u1eefu c\u01a1, acid lo\u00e3ng l\u1ea1nh v\u00e0 dung d\u1ecbch hydroxyd ki\u1ec1m.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      Kaolin b\u1ec1n. L\u00e0 kho\u00e1ng t\u1ef1 nhi\u00ean n\u00ean th\u01b0\u1eddng nhi\u1ec5m vi sinh (k\u1ec3 c\u1ea3 Bacillus anthracis<\/em>, Clostridium tetani<\/em>, C. welchii<\/em>) \u2013 c\u00f3 th\u1ec3 ti\u1ec7t khu\u1ea9n b\u1eb1ng nhi\u1ec7t tr\u00ean 160 \u00b0C \u00edt nh\u1ea5t 1 gi\u1edd. Khi l\u00e0m \u1ea9m, kaolin s\u1eabm m\u00e0u v\u00e0 tr\u1edf n\u00ean d\u1ebbo. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u00ednh h\u1ea5p ph\u1ee5 c\u1ee7a kaolin c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng h\u1ea5p thu c\u00e1c thu\u1ed1c u\u1ed1ng kh\u00e1c \u2013 \u0111\u00e3 ghi nh\u1eadn v\u1edbi amoxicilin, ampicilin, cimetidin, digoxin, lincomycin, phenytoin, tetracyclin. Kaolin c\u0169ng l\u00e0m gi\u1ea3m hi\u1ec7u l\u1ef1c m\u1ed9t s\u1ed1 ch\u1ea5t b\u1ea3o qu\u1ea3n (nh\u01b0 acid benzoic, benzalkonium clorid).<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Khai th\u00e1c t\u1eeb m\u1ecf kho\u00e1ng t\u1ef1 nhi\u00ean (l\u1edbn \u1edf Georgia \u2013 M\u1ef9 v\u00e0 Cornwall \u2013 Anh), nghi\u1ec1n v\u00e0 lo\u1ea1i h\u1ea1t th\u00f4 b\u1eb1ng g\u1ea1n l\u1eafng ho\u1eb7c r\u00e2y; lo\u1ea1i t\u1ea1p ch\u1ea5t nh\u01b0 s\u1eaft (III) oxyd, calci carbonat, magnesi carbonat b\u1eb1ng nam ch\u00e2m \u0111i\u1ec7n v\u00e0 x\u1eed l\u00fd acid hydrocloric v\u00e0\/ho\u1eb7c sulfuric.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      D\u00f9ng trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i, \u0111\u01b0\u1ee3c xem l\u00e0 g\u1ea7n nh\u01b0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. H\u00edt b\u1ee5i kaolin l\u00e2u d\u00e0i c\u00f3 th\u1ec3 g\u00e2y b\u1ec7nh ph\u1ed5i (b\u1ee5i ph\u1ed5i silic, b\u1ec7nh b\u1ee5i ph\u1ed5i kaolin) \u2013 d\u00f9ng k\u00ednh, kh\u1ea9u trang ch\u1ed1ng b\u1ee5i. Gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m t\u1ea1i Anh v\u1edbi b\u1ee5i h\u00f4 h\u1ea5p kaolin: 2 mg\/m\u00b3 (8 gi\u1edd).<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u cho m\u1ed9t s\u1ed1 \u1ee9ng d\u1ee5ng (E559).<\/li>\n
      • C\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean nang, b\u1ed9t, siro, vi\u00ean n\u00e9n u\u1ed1ng; d\u00f9ng ngo\u00e0i); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong JP, BP, Ph.Eur., USP; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> bentonit, magnesi nh\u00f4m silicat, attapulgit, talc.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Kaolin<\/em> trong:
        \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
        \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
        \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
        \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
        \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Kaolin (cao lanh, E559) \u2013 ch\u1ea5t h\u1ea5p ph\u1ee5, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, b\u1ed9t r\u1eafc Kaolin (cao lanh, China clay, E559) l\u00e0 nh\u00f4m silicat ng\u1eadm n\u01b0\u1edbc t\u1ef1 nhi\u00ean, \u0111\u01b0\u1ee3c nghi\u1ec1n v\u00e0 lo\u1ea1i h\u1ea1t s\u1ea1n b\u1eb1ng g\u1ea1n l\u1eafng. Trong b\u00e0o ch\u1ebf, kaolin t\u1eebng \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n, vi\u00ean nang, ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch v\u00e0 […]<\/p>","protected":false},"author":1,"featured_media":2399,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2400","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kaolin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kaolin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kaolin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kaolin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kaolin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kaolin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kaolin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kaolin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Kaolin (cao lanh, E559) \u2013 ch\u1ea5t h\u1ea5p ph\u1ee5, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, b\u1ed9t r\u1eafc Kaolin (cao lanh, China clay, E559) l\u00e0 nh\u00f4m silicat ng\u1eadm n\u01b0\u1edbc t\u1ef1 nhi\u00ean, \u0111\u01b0\u1ee3c nghi\u1ec1n v\u00e0 lo\u1ea1i h\u1ea1t s\u1ea1n b\u1eb1ng g\u1ea1n l\u1eafng. Trong b\u00e0o ch\u1ebf, kaolin t\u1eebng \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n, vi\u00ean nang, ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch v\u00e0…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2400"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2400\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2399"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}