{"id":2390,"date":"2026-09-27T11:42:55","date_gmt":"2026-09-27T04:42:55","guid":{"rendered":"https:\/\/cpc1.vn\/isomalt\/"},"modified":"2026-09-27T11:42:55","modified_gmt":"2026-09-27T04:42:55","slug":"isomalt","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/isomalt\/","title":{"rendered":"Isomalt (E953) \u2013 polyol t\u1ea1o ng\u1ecdt, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho vi\u00ean nhai, k\u1eb9o ng\u1eadm"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Isomalt (E953) \u2013 polyol t\u1ea1o ng\u1ecdt, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho vi\u00ean nhai, k\u1eb9o ng\u1eadm<\/h1>\n<p><strong>Isomalt<\/strong> (E953) l\u00e0 \u0111\u01b0\u1eddng alcol (polyol) s\u1ea3n xu\u1ea5t t\u1eeb \u0111\u01b0\u1eddng c\u1ee7 c\u1ea3i, g\u1ed3m h\u1ed7n h\u1ee3p hai \u0111\u1ed3ng ph\u00e2n: <strong>1,6-GPS<\/strong> (6-O-\u03b1-D-glucopyranosyl-D-sorbitol) v\u00e0 <strong>1,1-GPM<\/strong> (1-O-\u03b1-D-glucopyranosyl-D-mannitol dihydrat). Isomalt ng\u1ecdt kho\u1ea3ng 50\u201360% saccarose, <strong>kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng<\/strong>, kh\u00f4ng h\u00fat \u1ea9m v\u00e0 r\u1ea5t b\u1ec1n \u2013 ph\u00f9 h\u1ee3p cho vi\u00ean nhai, k\u1eb9o ng\u1eadm, k\u1eb9o c\u1ee9ng kh\u00f4ng \u0111\u01b0\u1eddng.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Hydrogenated isomaltulose, hydrogenated palatinose, E953; GalenIQ, Palatinit, Isomaltidex 16500<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>64519-82-0 (isomalt); 534-73-6 (1,6-GPS); 20942-99-8 (1,1-GPM)<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>12<\/sub>H<sub>24<\/sub>O<sub>11<\/sub> \u2013 344,32 (khan); dihydrat 380,32<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>N\u1ec1n k\u1eb9o thu\u1ed1c, t\u00e1 d\u01b0\u1ee3c bao, t\u1ea1o h\u1ea1t, t\u1ea1o ng\u1ecdt, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>1,6-GPS tan t\u1ed1t h\u01a1n 1,1-GPM \u2013 thay \u0111\u1ed5i t\u1ef7 l\u1ec7 hai th\u00e0nh ph\u1ea7n \u0111i\u1ec1u ch\u1ec9nh \u0111\u01b0\u1ee3c \u0111\u1ed9 tan v\u00e0 l\u01b0\u1ee3ng n\u01b0\u1edbc k\u1ebft tinh. V\u00ed d\u1ee5 GalenIQ 720 c\u00f3 t\u1ef7 l\u1ec7 GPM:GPS 1:1; GalenIQ 721 l\u00e0 1:3.<\/p>\n<h2>Applications<\/h2>\n<ul>\n<li>T\u00e1 d\u01b0\u1ee3c cho vi\u00ean n\u00e9n, vi\u00ean nang, l\u1edbp bao, g\u00f3i b\u1ed9t, h\u1ed7n d\u1ecbch, vi\u00ean s\u1ee7i; d\u00f9ng \u0111\u01b0\u1ee3c cho d\u1eadp th\u1eb3ng v\u00e0 x\u00e1t h\u1ea1t \u01b0\u1edbt.<\/li>\n<li><strong>Vi\u00ean nhai, vi\u00ean ng\u1eadm<\/strong>: nhi\u1ec7t h\u00f2a tan g\u1ea7n nh\u01b0 kh\u00f4ng \u00e2m (kh\u00f4ng t\u1ea1o c\u1ea3m gi\u00e1c m\u00e1t nh\u01b0 erythritol, xylitol), v\u1ecb ng\u1ecdt nh\u1eb9, c\u1ea3m gi\u00e1c mi\u1ec7ng d\u1ec5 ch\u1ecbu.<\/li>\n<li>K\u1eb9o ng\u1eadm, k\u1eb9o cao su kh\u00f4ng \u0111\u01b0\u1eddng, k\u1eb9o c\u1ee9ng; ch\u1ea5t t\u1ea1o ng\u1ecdt cho b\u00e1nh k\u1eb9o d\u00e0nh cho ng\u01b0\u1eddi c\u1ea7n ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng.<\/li>\n<li>D\u1eadp isomalt c\u1ea7n t\u00e1 d\u01b0\u1ee3c tr\u01a1n (nh\u01b0 magnesi stearat) \u0111\u1ec3 tr\u00e1nh d\u00ednh th\u00e0nh c\u1ed1i, bong n\u1eafp, t\u00e1ch l\u1edbp; \u00e9p \u0111\u00f9n \u0111\u1ed3ng th\u1eddi v\u1edbi paracetamol c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng d\u1eadp vi\u00ean; c\u00f3 th\u1ec3 d\u00f9ng k\u1ef9 thu\u1eadt \u0111\u00fac tr\u1ef1c ti\u1ebfp.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t, h\u1ea1t ho\u1eb7c tinh th\u1ec3 tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, v\u1ecb ng\u1ecdt gi\u1ed1ng \u0111\u01b0\u1eddng.<\/li>\n<li>N\u00f3ng ch\u1ea3y 141\u2013161 \u00b0C (h\u1ed7n h\u1ee3p GPM:GPS 1:3); 166\u2013168 \u00b0C (1,6-GPS); 168\u2013171 \u00b0C (1,1-GPM).<\/li>\n<li>Nhi\u1ec7t \u0111\u1ed9 h\u00f3a th\u1ee7y tinh 59\u201368 \u00b0C \u2013 quan tr\u1ecdng khi l\u00e0m k\u1eb9o c\u1ee9ng.<\/li>\n<li>T\u1ef7 tr\u1ecdng th\u1ef1c 1,47\u20131,52 g\/cm\u00b3; b\u1ed9t d\u00ednh, d\u1ea1ng h\u1ea1t tr\u01a1n ch\u1ea3y t\u1ed1t.<\/li>\n<li><strong>Kh\u00f4ng h\u00fat \u1ea9m \u0111\u1ebfn 85% RH<\/strong> (25 \u00b0C).<\/li>\n<li>\u1ed4n \u0111\u1ecbnh \u1edf pH 3\u201310.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>R\u1ea5t b\u1ec1n nhi\u1ec7t v\u00e0 h\u00f3a h\u1ecdc: n\u00f3ng ch\u1ea3y kh\u00f4ng thay \u0111\u1ed5i c\u1ea5u tr\u00fac ph\u00e2n t\u1eed; b\u1ec1n v\u1edbi acid v\u00e0 vi sinh. Vi\u00ean paracetamol n\u1ec1n isomalt gi\u1eef nguy\u00ean h\u00ecnh th\u1ee9c sau 6 th\u00e1ng \u1edf 85% RH, 20 \u00b0C. Bao b\u00ec ch\u01b0a m\u1edf \u1edf 20 \u00b0C\/60% RH n\u00ean \u0111\u00e1nh gi\u00e1 l\u1ea1i sau 3 n\u0103m. <strong>Kh\u00f4ng c\u00f3 nh\u00f3m kh\u1eed \u2013 kh\u00f4ng g\u00e2y ph\u1ea3n \u1ee9ng h\u00f3a n\u00e2u Maillard<\/strong> v\u1edbi amin.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Hai giai \u0111o\u1ea1n t\u1eeb saccarose c\u1ea5p th\u1ef1c ph\u1ea9m: chuy\u1ec3n glucosid b\u1eb1ng enzym th\u00e0nh isomaltulose (disaccharid kh\u1eed), sau \u0111\u00f3 hydro h\u00f3a x\u00fac t\u00e1c th\u00e0nh isomalt.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>\u0110\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng g\u00e2y d\u1ecb \u1ee9ng, kh\u00f4ng k\u00edch \u1ee9ng; JECFA x\u1ebfp ADI &#8220;kh\u00f4ng x\u00e1c \u0111\u1ecbnh&#8221;. Li\u00ean k\u1ebft glycosid r\u1ea5t b\u1ec1n n\u00ean isomalt \u00edt b\u1ecb th\u1ee7y ph\u00e2n, h\u1ea5p thu \u1edf ru\u1ed9t non; ph\u1ea7n l\u1edbn l\u00ean men \u1edf \u0111\u1ea1i tr\u00e0ng \u2013 d\u00f9ng qu\u00e1 nhi\u1ec1u c\u00f3 th\u1ec3 nhu\u1eadn tr\u00e0ng. H\u1ea7u nh\u01b0 kh\u00f4ng l\u00e0m t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft. Vi khu\u1ea9n mi\u1ec7ng kh\u00f4ng l\u00ean men isomalt n\u00ean kh\u00f4ng t\u1ea1o acid h\u1ea1i men r\u0103ng. D\u00f9ng k\u00ednh, g\u0103ng tay, kh\u1ea9u trang khi thao t\u00e1c.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>FDA x\u1ebfp nh\u00f3m GRAS; \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E953).<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> maltitol, mannitol, sorbitol, xylitol, erythritol.<\/p>\n<h2>Nguy\u00ean li\u1ec7u t\u1ea1i CPC1<\/h2>\n<p>CPC1 \u0111ang cung c\u1ea5p c\u00e1c nguy\u00ean li\u1ec7u li\u00ean quan d\u01b0\u1edbi \u0111\u00e2y. Li\u00ean h\u1ec7 \u0111\u1ec3 nh\u1eadn COA v\u00e0 b\u00e1o gi\u00e1 theo l\u00f4 h\u00e0ng hi\u1ec7n c\u00f3.<\/p>\n<ul>\n<li><a href=\"https:\/\/cpc1.vn\/en\/san-pham\/nguyen-lieu-isomalt-st-m-25kg-bag\/\">ISOMALT ST-M 25KG\/BAG<\/a><\/li>\n<li><a href=\"https:\/\/cpc1.vn\/en\/san-pham\/nguyen-lieu-isomalt-chat-tao-ngot-tong-hop-isomalt-qingdao\/\">Isomalt \u2013 Ch\u1ea5t t\u1ea1o ng\u1ecdt (Qingdao)<\/a><\/li>\n<\/ul>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Isomalt<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Isomalt (E953) \u2013 polyol t\u1ea1o ng\u1ecdt, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho vi\u00ean nhai, k\u1eb9o ng\u1eadm Isomalt (E953) l\u00e0 \u0111\u01b0\u1eddng alcol (polyol) s\u1ea3n xu\u1ea5t t\u1eeb \u0111\u01b0\u1eddng c\u1ee7 c\u1ea3i, g\u1ed3m h\u1ed7n h\u1ee3p hai \u0111\u1ed3ng ph\u00e2n: 1,6-GPS (6-O-\u03b1-D-glucopyranosyl-D-sorbitol) v\u00e0 1,1-GPM (1-O-\u03b1-D-glucopyranosyl-D-mannitol dihydrat). Isomalt ng\u1ecdt kho\u1ea3ng 50\u201360% saccarose, kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng, kh\u00f4ng h\u00fat \u1ea9m v\u00e0 r\u1ea5t b\u1ec1n \u2013 ph\u00f9 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2389,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2390","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isomalt.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isomalt-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isomalt-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isomalt-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isomalt-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isomalt.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isomalt.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isomalt-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Isomalt (E953) \u2013 polyol t\u1ea1o ng\u1ecdt, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho vi\u00ean nhai, k\u1eb9o ng\u1eadm Isomalt (E953) l\u00e0 \u0111\u01b0\u1eddng alcol (polyol) s\u1ea3n xu\u1ea5t t\u1eeb \u0111\u01b0\u1eddng c\u1ee7 c\u1ea3i, g\u1ed3m h\u1ed7n h\u1ee3p hai \u0111\u1ed3ng ph\u00e2n: 1,6-GPS (6-O-\u03b1-D-glucopyranosyl-D-sorbitol) v\u00e0 1,1-GPM (1-O-\u03b1-D-glucopyranosyl-D-mannitol dihydrat). Isomalt ng\u1ecdt kho\u1ea3ng 50\u201360% saccarose, kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng, kh\u00f4ng h\u00fat \u1ea9m v\u00e0 r\u1ea5t b\u1ec1n \u2013 ph\u00f9&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2390"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2390\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2389"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}