{"id":2386,"date":"2026-09-27T11:41:46","date_gmt":"2026-09-27T04:41:46","guid":{"rendered":"https:\/\/cpc1.vn\/imidurea\/"},"modified":"2026-09-28T21:14:59","modified_gmt":"2026-09-28T14:14:59","slug":"imidurea","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/imidurea\/","title":{"rendered":"Imidurea (imidazolidinyl urea) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c d\u00f9ng ngo\u00e0i"},"content":{"rendered":"

Imidurea (imidazolidinyl urea) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c d\u00f9ng ngo\u00e0i<\/h1>\n

Imidurea<\/strong> (imidazolidinyl urea, Germall 115) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n ph\u1ed5 r\u1ed9ng, n\u1ed5i ti\u1ebfng nh\u1ea5t trong h\u1ecd d\u1eabn ch\u1ea5t ur\u00ea d\u1ecb v\u00f2ng. Imidurea \u0111\u01b0\u1ee3c d\u00f9ng trong m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c d\u00f9ng ngo\u00e0i \u1edf n\u1ed3ng \u0111\u1ed9 0,03\u20130,5%<\/strong>, th\u01b0\u1eddng ph\u1ed1i h\u1ee3p v\u1edbi paraben \u0111\u1ec3 t\u0103ng t\u00e1c d\u1ee5ng tr\u00ean n\u1ea5m.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nImidazolidinyl urea; Germall 115, Biopure 100, Tri-Stat IU<\/td>\n<\/tr>\n
T\u00ean h\u00f3a h\u1ecdc<\/td>\nN,N”-Methylenbis{N’-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]ur\u00ea}<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n39236-46-9<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC11<\/sub>H16<\/sub>N8<\/sub>O8<\/sub> \u2013 388,29 (khan); monohydrat 406,33<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Ho\u1ea1t t\u00ednh v\u00e0 \u1ee9ng d\u1ee5ng<\/h2>\n
    \n
  • Ch\u1ee7 y\u1ebfu kh\u00e1ng vi khu\u1ea9n, c\u00f3 m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ch\u1ecdn l\u1ecdc tr\u00ean n\u1ea5m.<\/li>\n
  • Hi\u1ec7u qu\u1ea3 \u1edf pH 3\u20139, t\u1ed1t nh\u1ea5t trong dung d\u1ecbch h\u01a1i acid; n\u1ed3ng \u0111\u1ed9 0,03\u20130,5%.<\/li>\n
  • Hi\u1ec7p \u0111\u1ed3ng v\u1edbi paraben<\/strong>, \u0111\u1eb7c bi\u1ec7t tr\u00ean n\u1ea5m. V\u00ed d\u1ee5 c\u00f4ng th\u1ee9c m\u1ef9 ph\u1ea9m ch\u1ee9a imidurea 0,5% + methylparaben 0,2% + propylparaben 0,1% \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n hi\u1ec7u qu\u1ea3 ch\u1ed1ng nhi\u1ec1u lo\u00e0i Pseudomonas<\/em>.<\/li>\n
  • MIC tham kh\u1ea3o: S. aureus<\/em> kho\u1ea3ng 1000 \u00b5g\/mL; E. coli<\/em>, P. aeruginosa<\/em> kho\u1ea3ng 2000 \u00b5g\/mL; A. niger<\/em>, C. albicans<\/em> kho\u1ea3ng 8000 \u00b5g\/mL \u2013 cho th\u1ea5y t\u00e1c d\u1ee5ng tr\u00ean n\u1ea5m y\u1ebfu h\u01a1n, l\u00fd do n\u00ean ph\u1ed1i h\u1ee3p paraben.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng, tr\u01a1n ch\u1ea3y, kh\u00f4ng m\u00f9i.<\/li>\n
    • pH dung d\u1ecbch 1%: 6,0\u20137,5.<\/li>\n
    • R\u1ea5t d\u1ec5 tan trong n\u01b0\u1edbc (1\/0,5), glycerin (1\/1, tan ch\u1eadm), propylen glycol (1\/0,8), ethylen glycol; tan 1\/0,8 trong ethanol 30% nh\u01b0ng r\u1ea5t kh\u00f3 tan trong ethanol \u0111\u1eadm \u0111\u1eb7c; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong d\u1ea7u kho\u00e1ng, isopropanol.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      H\u00fat \u1ea9m \u2013 b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng h\u1ee3p<\/h2>\n

      T\u01b0\u01a1ng h\u1ee3p v\u1edbi c\u00e1c ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c (acid sorbic, h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n) v\u00e0 v\u1edbi nhi\u1ec1u t\u00e1 d\u01b0\u1ee3c d\u01b0\u1ee3c ph\u1ea9m, m\u1ef9 ph\u1ea9m nh\u01b0 protein, ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion h\u00f3a, lecithin \u2013 \u01b0u \u0111i\u1ec3m so v\u1edbi paraben (v\u1ed1n b\u1ecb ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion h\u00f3a l\u00e0m gi\u1ea3m hi\u1ec7u l\u1ef1c).<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      T\u1ed5ng h\u1ee3p theo quy tr\u00ecnh ph\u1ee9c t\u1ea1p.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      \u0110\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c d\u00f9ng ngo\u00e0i, \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; c\u00f3 m\u1ed9t s\u1ed1 b\u00e1o c\u00e1o vi\u00eam da ti\u1ebfp x\u00fac (t\u01b0\u01a1ng \u0111\u1ed1i \u00edt so v\u1edbi m\u1ee9c \u0111\u1ed9 s\u1eed d\u1ee5ng). Imidurea gi\u1ea3i ph\u00f3ng formaldehyd nh\u01b0ng d\u01b0\u1eddng nh\u01b0 kh\u00f4ng g\u00e2y m\u1eabn c\u1ea3m ch\u00e9o v\u1edbi formaldehyd hay c\u00e1c ch\u1ea5t gi\u1ea3i ph\u00f3ng formaldehyd kh\u00e1c. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft \u2013 d\u00f9ng k\u00ednh, g\u0103ng tay.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • C\u00f3 trong FDA Inactive Ingredients Guide (ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i).<\/li>\n
      • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn trong m\u1ef9 ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u v\u00e0 M\u1ef9; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> diazolidinyl urea<\/strong> (Germall II; C8<\/sub>H14<\/sub>N4<\/sub>O7<\/sub>, 278,23; CAS 78491-02-8) \u2013 ch\u1ea5t m\u1ea1nh nh\u1ea5t trong h\u1ecd, d\u00f9ng 0,1\u20130,5% \u1edf pH 3\u20139, r\u1ea5t d\u1ec5 tan trong n\u01b0\u1edbc.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Imidurea<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

        Imidurea (imidazolidinyl urea) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c d\u00f9ng ngo\u00e0i Imidurea (imidazolidinyl urea, Germall 115) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n ph\u1ed5 r\u1ed9ng, n\u1ed5i ti\u1ebfng nh\u1ea5t trong h\u1ecd d\u1eabn ch\u1ea5t ur\u00ea d\u1ecb v\u00f2ng. Imidurea \u0111\u01b0\u1ee3c d\u00f9ng trong m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c d\u00f9ng ngo\u00e0i \u1edf n\u1ed3ng \u0111\u1ed9 0,03\u20130,5%, th\u01b0\u1eddng ph\u1ed1i h\u1ee3p v\u1edbi […]<\/p>\n","protected":false},"author":1,"featured_media":2385,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2386","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/imidurea.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/imidurea-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/imidurea-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/imidurea-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/imidurea-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/imidurea.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/imidurea.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/imidurea-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Imidurea (imidazolidinyl urea) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c d\u00f9ng ngo\u00e0i Imidurea (imidazolidinyl urea, Germall 115) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n ph\u1ed5 r\u1ed9ng, n\u1ed5i ti\u1ebfng nh\u1ea5t trong h\u1ecd d\u1eabn ch\u1ea5t ur\u00ea d\u1ecb v\u00f2ng. Imidurea \u0111\u01b0\u1ee3c d\u00f9ng trong m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c d\u00f9ng ngo\u00e0i \u1edf n\u1ed3ng \u0111\u1ed9 0,03\u20130,5%, th\u01b0\u1eddng ph\u1ed1i h\u1ee3p v\u1edbi…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2386"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2386\/revisions"}],"predecessor-version":[{"id":3261,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2386\/revisions\/3261"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2385"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}