{"id":2376,"date":"2026-09-27T11:38:43","date_gmt":"2026-09-27T04:38:43","guid":{"rendered":"https:\/\/cpc1.vn\/hydroxypropyl-cellulose-the-thap-l-hpc\/"},"modified":"2026-09-28T21:14:38","modified_gmt":"2026-09-28T14:14:38","slug":"hydroxypropyl-cellulose-the-thap-l-hpc","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/hydroxypropyl-cellulose-the-thap-l-hpc\/","title":{"rendered":"Hydroxypropyl cellulose th\u1ebf th\u1ea5p (L-HPC) \u2013 t\u00e1 d\u01b0\u1ee3c r\u00e3 v\u00e0 d\u00ednh cho vi\u00ean n\u00e9n"},"content":{"rendered":"

Hydroxypropyl cellulose th\u1ebf th\u1ea5p (L-HPC) \u2013 t\u00e1 d\u01b0\u1ee3c r\u00e3 v\u00e0 d\u00ednh cho vi\u00ean n\u00e9n<\/h1>\n

Hydroxypropyl cellulose th\u1ebf th\u1ea5p<\/strong> (L-HPC, hyprolose th\u1ebf th\u1ea5p) ch\u1ec9 ch\u1ee9a 5,0\u201316,0% nh\u00f3m hydroxypropoxy \u2013 \u00edt h\u01a1n nhi\u1ec1u so v\u1edbi HPC th\u00f4ng th\u01b0\u1eddng. V\u00ec v\u1eady L-HPC kh\u00f4ng tan m\u00e0 tr\u01b0\u01a1ng n\u1edf trong n\u01b0\u1edbc<\/strong>, \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c r\u00e3<\/strong> ki\u00eam t\u00e1 d\u01b0\u1ee3c d\u00ednh cho vi\u00ean n\u00e9n.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nL-HPC, hyprolose low-substituted<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n78214-41-2<\/td>\n<\/tr>\n
C\u1ea5u t\u1ea1o<\/td>\nEther hydroxypropyl th\u1ebf th\u1ea5p c\u1ee7a cellulose; 5,0\u201316,0% nh\u00f3m \u2013OCH2<\/sub>CHOHCH3<\/sub> (USP-NF, sau khi s\u1ea5y)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nT\u00e1 d\u01b0\u1ee3c r\u00e3 vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang, t\u00e1 d\u01b0\u1ee3c d\u00ednh vi\u00ean n\u00e9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • T\u00e1 d\u01b0\u1ee3c r\u00e3 v\u00e0 t\u00e1 d\u01b0\u1ee3c d\u00ednh trong x\u00e1t h\u1ea1t \u01b0\u1edbt; h\u00e0m l\u01b0\u1ee3ng \u0111i\u1ec3n h\u00ecnh kho\u1ea3ng 5\u201325%<\/strong>.<\/li>\n
  • Vi\u00ean r\u00e3 nhanh b\u1eb1ng d\u1eadp th\u1eb3ng.<\/li>\n
  • D\u00f9ng \u0111\u1ec3 l\u00e0m ch\u1eadm gi\u1ea3i ph\u00f3ng ho\u1ea1t ch\u1ea5t t\u1eeb c\u1ed1t vi\u00ean.<\/li>\n<\/ul>\n

    C\u00e1c c\u1ea5p th\u01b0\u01a1ng m\u1ea1i (Shin-Etsu)<\/h2>\n\n\n\n\n\n\n\n\n\n
    C\u1ea5p<\/th>\n\u0110\u1eb7c \u0111i\u1ec3m v\u00e0 \u1ee9ng d\u1ee5ng<\/th>\n<\/tr>\n<\/thead>\n
    LH-11<\/td>\nM\u1ee9c th\u1ebf trung b\u00ecnh, c\u1ee1 h\u1ea1t l\u1edbn nh\u1ea5t \u2013 ch\u1ed1ng bong n\u1eafp, t\u00e1 d\u01b0\u1ee3c r\u00e3 cho d\u1eadp th\u1eb3ng<\/td>\n<\/tr>\n
    LH-21<\/td>\nT\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 r\u00e3 cho x\u00e1t h\u1ea1t \u01b0\u1edbt<\/td>\n<\/tr>\n
    LH-31<\/td>\nH\u1ea1t nh\u1ecf \u2013 th\u00edch h\u1ee3p \u00e9p \u0111\u00f9n t\u1ea1o h\u1ea1t (d\u1ec5 qua l\u01b0\u1edbi)<\/td>\n<\/tr>\n
    LH-22, LH-32<\/td>\nM\u1ee9c th\u1ebf th\u1ea5p h\u01a1n \u2013 khi kh\u00f4ng c\u1ea7n l\u1ef1c d\u00ednh cao<\/td>\n<\/tr>\n
    LH-20, LH-30<\/td>\nM\u1ee9c th\u1ebf cao h\u01a1n \u2013 khi c\u1ea7n l\u1ef1c d\u00ednh cao h\u01a1n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t ho\u1eb7c h\u1ea1t tr\u1eafng \u0111\u1ebfn tr\u1eafng ng\u00e0, kh\u00f4ng m\u00f9i ho\u1eb7c m\u00f9i nh\u1eb9, kh\u00f4ng v\u1ecb.<\/li>\n
    • pH h\u1ed7n d\u1ecbch 1%: 5,0\u20137,5; t\u1ef7 tr\u1ecdng 1,46; t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn kho\u1ea3ng 0,28\u20130,36 g\/cm\u00b3, t\u1ef7 tr\u1ecdng g\u00f5 0,56\u20130,62 g\/cm\u00b3.<\/li>\n
    • Ph\u00e2n h\u1ee7y \u1edf 275 \u00b0C.<\/li>\n
    • H\u00fat \u1ea9m: 8% \u1edf 33% RH, 38% \u1edf 95% RH.<\/li>\n
    • Kh\u00f4ng tan nh\u01b0ng tr\u01b0\u01a1ng n\u1edf trong n\u01b0\u1edbc; tan trong NaOH 10% t\u1ea1o dung d\u1ecbch nh\u1edbt; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ethanol 95% v\u00e0 ether.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n nh\u01b0ng h\u00fat \u1ea9m; b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      C\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi ch\u1ea5t ki\u1ec1m \u2013 vi\u00ean ch\u1ee9a ch\u1ea5t ki\u1ec1m c\u00f3 th\u1ec3 k\u00e9o d\u00e0i th\u1eddi gian r\u00e3 sau b\u1ea3o qu\u1ea3n.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cellulose ki\u1ec1m ph\u1ea3n \u1ee9ng v\u1edbi propylen oxyd \u1edf nhi\u1ec7t \u0111\u1ed9 cao; sau ph\u1ea3n \u1ee9ng, s\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c k\u1ebft tinh l\u1ea1i b\u1eb1ng trung h\u00f2a, r\u1eeda v\u00e0 nghi\u1ec1n.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      \u0110\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. Chu\u1ed9t u\u1ed1ng 6 g\/kg\/ng\u00e0y trong 6 th\u00e1ng kh\u00f4ng th\u1ea5y t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i; kh\u00f4ng g\u00e2y qu\u00e1i thai tr\u00ean th\u1ecf v\u00e0 chu\u1ed9t \u1edf 5 g\/kg\/ng\u00e0y. Tr\u00e1nh t\u1ea1o nhi\u1ec1u b\u1ee5i \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 n\u1ed5.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • \u0110\u01b0\u1ee3c ph\u00e9p d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u, Nh\u1eadt B\u1ea3n, M\u1ef9 v\u00e0 nhi\u1ec1u n\u01b0\u1edbc; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong JP v\u00e0 USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> hydroxypropyl cellulose, croscarmellose natri, crospovidon.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Hydroxypropyl Cellulose, Low-substituted<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Hydroxypropyl cellulose th\u1ebf th\u1ea5p (L-HPC) \u2013 t\u00e1 d\u01b0\u1ee3c r\u00e3 v\u00e0 d\u00ednh cho vi\u00ean n\u00e9n Hydroxypropyl cellulose th\u1ebf th\u1ea5p (L-HPC, hyprolose th\u1ebf th\u1ea5p) ch\u1ec9 ch\u1ee9a 5,0\u201316,0% nh\u00f3m hydroxypropoxy \u2013 \u00edt h\u01a1n nhi\u1ec1u so v\u1edbi HPC th\u00f4ng th\u01b0\u1eddng. V\u00ec v\u1eady L-HPC kh\u00f4ng tan m\u00e0 tr\u01b0\u01a1ng n\u1edf trong n\u01b0\u1edbc, \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c r\u00e3 ki\u00eam t\u00e1 d\u01b0\u1ee3c […]<\/p>\n","protected":false},"author":1,"featured_media":2375,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2376","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-the-thap-l-hpc.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-the-thap-l-hpc-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-the-thap-l-hpc-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-the-thap-l-hpc-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-the-thap-l-hpc-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-the-thap-l-hpc.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-the-thap-l-hpc.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-the-thap-l-hpc-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Hydroxypropyl cellulose th\u1ebf th\u1ea5p (L-HPC) \u2013 t\u00e1 d\u01b0\u1ee3c r\u00e3 v\u00e0 d\u00ednh cho vi\u00ean n\u00e9n Hydroxypropyl cellulose th\u1ebf th\u1ea5p (L-HPC, hyprolose th\u1ebf th\u1ea5p) ch\u1ec9 ch\u1ee9a 5,0\u201316,0% nh\u00f3m hydroxypropoxy \u2013 \u00edt h\u01a1n nhi\u1ec1u so v\u1edbi HPC th\u00f4ng th\u01b0\u1eddng. V\u00ec v\u1eady L-HPC kh\u00f4ng tan m\u00e0 tr\u01b0\u01a1ng n\u1edf trong n\u01b0\u1edbc, \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c r\u00e3 ki\u00eam t\u00e1 d\u01b0\u1ee3c…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2376","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2376"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2376\/revisions"}],"predecessor-version":[{"id":3257,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2376\/revisions\/3257"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2375"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2376"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2376"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}