{"id":2374,"date":"2026-09-27T11:37:56","date_gmt":"2026-09-27T04:37:56","guid":{"rendered":"https:\/\/cpc1.vn\/hydroxypropyl-cellulose-hpc\/"},"modified":"2026-09-28T21:14:33","modified_gmt":"2026-09-28T14:14:33","slug":"hydroxypropyl-cellulose-hpc","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/hydroxypropyl-cellulose-hpc\/","title":{"rendered":"Hydroxypropyl cellulose (HPC, Klucel) \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh, bao phim, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i"},"content":{"rendered":"

Hydroxypropyl cellulose (HPC, Klucel) \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh, bao phim, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/h1>\n

Hydroxypropyl cellulose<\/strong> (HPC, hyprolose, E463) l\u00e0 ether poly(hydroxypropyl) m\u1ed9t ph\u1ea7n c\u1ee7a cellulose, c\u00f3 t\u00ednh ch\u1ea5t \u0111\u1eb7c bi\u1ec7t: v\u1eeba tan trong n\u01b0\u1edbc l\u1ea1nh v\u1eeba tan trong nhi\u1ec1u dung m\u00f4i h\u1eefu c\u01a1 ph\u00e2n c\u1ef1c<\/strong>, l\u1ea1i l\u00e0 polyme nhi\u1ec7t d\u1ebbo. HPC \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh, t\u00e1 d\u01b0\u1ee3c bao phim v\u00e0 c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nHyprolose, cellulose hydroxypropyl ether, oxypropylated cellulose, E463; Klucel, Nisso HPC<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n9004-64-2<\/td>\n<\/tr>\n
C\u1ea5u t\u1ea1o<\/td>\nEther poly(hydroxypropyl) m\u1ed9t ph\u1ea7n c\u1ee7a cellulose; KLPT 50.000\u20131.250.000 t\u00f9y c\u1ea5p; c\u00f3 th\u1ec3 ch\u1ee9a \u2264 0,6% silica l\u00e0m ch\u1ea5t ch\u1ed1ng v\u00f3n<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nT\u00e1 d\u01b0\u1ee3c bao, nh\u0169 h\u00f3a, \u1ed5n \u0111\u1ecbnh, t\u1ea1o h\u1ed7n d\u1ecbch, t\u00e1 d\u01b0\u1ee3c d\u00ednh vi\u00ean n\u00e9n, l\u00e0m \u0111\u1eb7c, t\u0103ng \u0111\u1ed9 nh\u1edbt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n\n\n\n\n\n\n\n
Vai tr\u00f2<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
C\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/td>\n15\u201335<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c d\u00ednh vi\u00ean n\u00e9n (x\u00e1t h\u1ea1t \u01b0\u1edbt ho\u1eb7c d\u1eadp th\u1eb3ng)<\/td>\n2\u20136<\/td>\n<\/tr>\n
Bao phim vi\u00ean n\u00e9n<\/td>\n5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • C\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/strong>: t\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng t\u0103ng khi \u0111\u1ed9 nh\u1edbt HPC gi\u1ea3m; th\u00eam ch\u1ea5t di\u1ec7n ho\u1ea1t anion l\u00e0m t\u0103ng \u0111\u1ed9 nh\u1edbt v\u00e0 l\u00e0m ch\u1eadm gi\u1ea3i ph\u00f3ng.<\/li>\n
  • Bao phim<\/strong>: dung d\u1ecbch n\u01b0\u1edbc (c\u00f3 th\u1ec3 k\u00e8m methylcellulose) ho\u1eb7c dung d\u1ecbch c\u1ed3n; acid stearic, palmitic l\u00e0m ch\u1ea5t h\u00f3a d\u1ebbo trong dung d\u1ecbch c\u1ed3n.<\/li>\n
  • Vi nang; l\u00e0m \u0111\u1eb7c; mi\u1ebfng d\u00e1n qua da, ch\u1ebf ph\u1ea9m nh\u1ecf m\u1eaft (k\u1ec3 c\u1ea3 que \u0111\u1eb7t m\u1eaft r\u1eafn).<\/li>\n
  • L\u00e0 polyme nhi\u1ec7t d\u1ebbo \u2013 d\u00f9ng \u0111\u01b0\u1ee3c trong \u00e9p \u0111\u00f9n n\u00f3ng ch\u1ea3y (v\u00ed d\u1ee5 m\u00e0ng d\u00f9ng ngo\u00e0i).<\/li>\n
  • HPC th\u1ebf th\u1ea5p (L-HPC) l\u00e0 t\u00e1 d\u01b0\u1ee3c r\u00e3 \u2013 xem b\u00e0i ri\u00eang.<\/li>\n
  • M\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m: nh\u0169 h\u00f3a, \u1ed5n \u0111\u1ecbnh.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng \u0111\u1ebfn h\u01a1i v\u00e0ng, kh\u00f4ng m\u00f9i, kh\u00f4ng v\u1ecb.<\/li>\n
    • pH dung d\u1ecbch 1%: 5,0\u20138,5; t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn kho\u1ea3ng 0,5 g\/cm\u00b3.<\/li>\n
    • M\u1ec1m \u1edf 130 \u00b0C; h\u00f3a than \u1edf 260\u2013275 \u00b0C.<\/li>\n
    • H\u00fat \u1ea9m: \u0111\u1ed9 \u1ea9m c\u00e2n b\u1eb1ng kho\u1ea3ng 4% \u1edf 50% RH v\u00e0 12% \u1edf 84% RH (25 \u00b0C).<\/li>\n
    • C\u00e1c c\u1ea5p Klucel theo KLPT: EF (80.000), LF (95.000), JF (140.000), GF (370.000), MF (850.000), HF (1.150.000).<\/li>\n
    • \u0110\u1ed9 tan<\/strong>: d\u1ec5 tan trong n\u01b0\u1edbc d\u01b0\u1edbi 38 \u00b0C t\u1ea1o dung d\u1ecbch keo trong; trong n\u01b0\u1edbc n\u00f3ng kh\u00f4ng tan \u2013 t\u1ee7a th\u00e0nh b\u00f4ng tr\u01b0\u01a1ng \u1edf 40\u201345 \u00b0C<\/strong>. Tan trong nhi\u1ec1u dung m\u00f4i ph\u00e2n c\u1ef1c n\u00f3ng ho\u1eb7c l\u1ea1nh (DMF, DMSO, dioxan, ethanol 95%, methanol, isopropanol 95%, propylen glycol) m\u00e0 kh\u00f4ng t\u1ee7a khi n\u00f3ng. V\u1edbi dung m\u00f4i “ranh gi\u1edbi” (aceton, diclomethan, methyl ethyl ceton\u2026) ch\u1ea5t l\u01b0\u1ee3ng dung d\u1ecbch ph\u1ee5 thu\u1ed9c c\u1ea5p \u2013 th\u00eam 5\u201315% \u0111\u1ed3ng dung m\u00f4i (v\u00ed d\u1ee5 10% methanol) gi\u00fap dung d\u1ecbch m\u1ecbn. Kh\u00f4ng tan trong hydrocarbon, glycerin, d\u1ea7u.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ed9t b\u1ec1n nh\u01b0ng h\u00fat \u1ea9m sau khi s\u1ea5y. Dung d\u1ecbch n\u01b0\u1edbc b\u1ec1n \u1edf pH 6,0\u20138,0; \u1edf pH th\u1ea5p b\u1ecb th\u1ee7y ph\u00e2n acid l\u00e0m c\u1eaft m\u1ea1ch, gi\u1ea3m \u0111\u1ed9 nh\u1edbt; dung d\u1ecbch c\u0169ng c\u00f3 th\u1ec3 b\u1ecb vi sinh ph\u00e2n h\u1ee7y \u2013 c\u1ea7n ch\u1ea5t b\u1ea3o qu\u1ea3n khi b\u1ea3o qu\u1ea3n l\u00e2u. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • Trong dung d\u1ecbch c\u00f3 t\u01b0\u01a1ng k\u1ef5 nh\u1ea5t \u0111\u1ecbnh v\u1edbi d\u1eabn ch\u1ea5t phenol th\u1ebf nh\u01b0 methylparaben, propylparaben.<\/li>\n
      • Polyme anion c\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u1ed9 nh\u1edbt dung d\u1ecbch HPC.<\/li>\n
      • Kh\u1ea3 n\u0103ng ch\u1ecbu mu\u1ed1i v\u00f4 c\u01a1 t\u00f9y lo\u1ea1i v\u00e0 n\u1ed3ng \u0111\u1ed9 mu\u1ed1i; HPC d\u1ec5 b\u1ecb “mu\u1ed1i k\u1ebft” khi c\u00f3 nhi\u1ec1u ch\u1ea5t tan kh\u00e1c c\u1ea1nh tranh n\u01b0\u1edbc \u2013 nhi\u1ec7t \u0111\u1ed9 t\u1ee7a c\u0169ng h\u1ea1 th\u1ea5p.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Cellulose tinh khi\u1ebft x\u1eed l\u00fd b\u1eb1ng natri hydroxyd t\u1ea1o cellulose ki\u1ec1m, sau \u0111\u00f3 ph\u1ea3n \u1ee9ng v\u1edbi propylen oxyd \u1edf nhi\u1ec7t \u0111\u1ed9 v\u00e0 \u00e1p su\u1ea5t cao. Nh\u00f3m hydroxypropyl ch\u1ee7 y\u1ebfu mang OH b\u1eadc hai, c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c ph\u1ea3n \u1ee9ng v\u1edbi propylen oxyd t\u1ea1o chu\u1ed7i nh\u00e1nh.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        D\u00f9ng r\u1ed9ng r\u00e3i trong thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i, m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m; \u0111\u01b0\u1ee3c xem l\u00e0 g\u1ea7n nh\u01b0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. Hi\u1ebfm g\u1eb7p kh\u00f3 ch\u1ecbu, k\u00edch \u1ee9ng, ph\u00f9 m\u00ed m\u1eaft v\u1edbi que \u0111\u1eb7t m\u1eaft HPC; c\u00f3 m\u1ed9t b\u00e1o c\u00e1o vi\u00eam da ti\u1ebfp x\u00fac v\u1edbi mi\u1ebfng d\u00e1n estradiol ch\u1ee9a HPC. WHO kh\u00f4ng quy \u0111\u1ecbnh ADI; d\u00f9ng qu\u00e1 nhi\u1ec1u c\u00f3 th\u1ec3 nhu\u1eadn tr\u00e0ng. B\u1ee5i c\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft; tr\u00e1nh t\u1ea1o b\u1ee5i (nguy c\u01a1 n\u1ed5).<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • FDA x\u1ebfp nh\u00f3m GRAS; \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E463).<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean nang, vi\u00ean n\u00e9n u\u1ed1ng; d\u00f9ng ngo\u00e0i, qua da); c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong JP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> hydroxyethyl cellulose, hydroxypropyl cellulose th\u1ebf th\u1ea5p, hypromellose.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Hydroxypropyl Cellulose<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Hydroxypropyl cellulose (HPC, Klucel) \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh, bao phim, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Hydroxypropyl cellulose (HPC, hyprolose, E463) l\u00e0 ether poly(hydroxypropyl) m\u1ed9t ph\u1ea7n c\u1ee7a cellulose, c\u00f3 t\u00ednh ch\u1ea5t \u0111\u1eb7c bi\u1ec7t: v\u1eeba tan trong n\u01b0\u1edbc l\u1ea1nh v\u1eeba tan trong nhi\u1ec1u dung m\u00f4i h\u1eefu c\u01a1 ph\u00e2n c\u1ef1c, l\u1ea1i l\u00e0 polyme nhi\u1ec7t d\u1ebbo. HPC \u0111\u01b0\u1ee3c d\u00f9ng […]<\/p>\n","protected":false},"author":1,"featured_media":2373,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2374","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-hpc.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-hpc-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-hpc-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-hpc-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-hpc-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-hpc.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-hpc.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-cellulose-hpc-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Hydroxypropyl cellulose (HPC, Klucel) \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh, bao phim, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Hydroxypropyl cellulose (HPC, hyprolose, E463) l\u00e0 ether poly(hydroxypropyl) m\u1ed9t ph\u1ea7n c\u1ee7a cellulose, c\u00f3 t\u00ednh ch\u1ea5t \u0111\u1eb7c bi\u1ec7t: v\u1eeba tan trong n\u01b0\u1edbc l\u1ea1nh v\u1eeba tan trong nhi\u1ec1u dung m\u00f4i h\u1eefu c\u01a1 ph\u00e2n c\u1ef1c, l\u1ea1i l\u00e0 polyme nhi\u1ec7t d\u1ebbo. HPC \u0111\u01b0\u1ee3c d\u00f9ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2374"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2374\/revisions"}],"predecessor-version":[{"id":3256,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2374\/revisions\/3256"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2373"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2374"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2374"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}