{"id":2364,"date":"2026-09-27T11:35:20","date_gmt":"2026-09-27T04:35:20","guid":{"rendered":"https:\/\/cpc1.vn\/hexetidin\/"},"modified":"2026-09-29T12:03:09","modified_gmt":"2026-09-29T05:03:09","slug":"hexetidin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/hexetidin\/","title":{"rendered":"Hexetidin \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 s\u00e1t khu\u1ea9n khoang mi\u1ec7ng"},"content":{"rendered":"

Hexetidin \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 s\u00e1t khu\u1ea9n khoang mi\u1ec7ng<\/h1>\n

Hexetidin<\/strong> l\u00e0 ch\u1ea5t kh\u00e1ng khu\u1ea9n ph\u1ed5 r\u1ed9ng kh\u00f4ng thu\u1ed9c nh\u00f3m kh\u00e1ng sinh, d\u1eabn ch\u1ea5t hexahydropyrimidin. Ch\u1ea5t n\u00e0y \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n<\/strong> trong m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam, v\u00e0 quen thu\u1ed9c nh\u1ea5t trong n\u01b0\u1edbc s\u00fac mi\u1ec7ng 0,1%<\/strong> v\u1edbi vai tr\u00f2 s\u00e1t khu\u1ea9n khoang mi\u1ec7ng.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\n5-Amino-1,3-bis(2-ethylhexyl)hexahydro-5-methylpyrimidine; Hexoral, Oraldene, Hextril, Glypesin, Sterisil<\/td>\n<\/tr>\n
T\u00ean h\u00f3a h\u1ecdc<\/td>\n1,3-bis(2-Ethylhexyl)-5-methylhexahydro-5-pyrimidinamin<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n141-94-6<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC21<\/sub>H45<\/sub>N3<\/sub> \u2013 339,61<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t s\u00e1t khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n trong m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam.<\/li>\n
  • Ho\u1ea1t ch\u1ea5t s\u00e1t khu\u1ea9n trong n\u01b0\u1edbc s\u00fac mi\u1ec7ng 0,1% cho c\u00e1c v\u1ea5n \u0111\u1ec1 nh\u1eb9 t\u1ea1i ch\u1ed7 \u1edf khoang mi\u1ec7ng (n\u1ed9i dung l\u00e2m s\u00e0ng kh\u00f4ng tr\u00ecnh b\u00e0y \u1edf \u0111\u00e2y).<\/li>\n<\/ul>\n

    Ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n<\/h2>\n
      \n
    • Ph\u1ed5 r\u1ed9ng: vi khu\u1ea9n Gram d\u01b0\u01a1ng, Gram \u00e2m v\u00e0 n\u1ea5m nh\u01b0 Candida albicans<\/em>; nhi\u1ec1u nghi\u00ean c\u1ee9u ghi nh\u1eadn t\u00e1c d\u1ee5ng ch\u1ed1ng m\u1ea3ng b\u00e1m r\u0103ng.<\/li>\n
    • C\u00f3 t\u00e1c d\u1ee5ng tr\u00ean S. aureus<\/em> v\u00e0 P. aeruginosa<\/em> d\u1ea1ng t\u1ef1 do v\u00e0 d\u1ea1ng m\u00e0ng sinh h\u1ecdc tr\u00ean PVC; l\u00e0m gi\u1ea3m b\u00e1m d\u00ednh c\u1ee7a C. albicans<\/em> l\u00ean t\u1ebf b\u00e0o ni\u00eam m\u1ea1c m\u00e1 in vitro.<\/li>\n
    • MIC tham kh\u1ea3o: Aspergillus niger<\/em>, Bacillus subtilis<\/em> < 25 \u00b5g\/mL; C. albicans<\/em> 250\u2013500 \u00b5g\/mL; E. coli<\/em>, P. aeruginosa<\/em> > 500 \u00b5g\/mL (trong th\u1eed nghi\u1ec7m MIC chu\u1ea9n).<\/li>\n<\/ul>\n

      M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
        \n
      • Ch\u1ea5t l\u1ecfng d\u1ea1ng d\u1ea7u kh\u00f4ng m\u00e0u ho\u1eb7c v\u00e0ng nh\u1ea1t, m\u00f9i amin \u0111\u1eb7c tr\u01b0ng.<\/li>\n
      • T\u1ef7 tr\u1ecdng 0,864\u20130,870 (20 \u00b0C); chi\u1ebft su\u1ea5t 1,463\u20131,467; pKa 8,3; s\u00f4i 172\u2013176 \u00b0C (\u00e1p su\u1ea5t gi\u1ea3m).<\/li>\n
      • Tan trong aceton, cloroform, diclomethan, ethanol 95%, methanol, n-hexan, ether d\u1ea7u h\u1ecfa, propylen glycol v\u00e0 acid v\u00f4 c\u01a1; r\u1ea5t kh\u00f3 tan trong n\u01b0\u1edbc.<\/li>\n<\/ul>\n

        \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

        B\u1ec1n; b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t. Kh\u00f4ng d\u00f9ng d\u1ee5ng c\u1ee5 b\u1eb1ng \u0111\u1ed3ng thau hay \u0111\u1ed3ng<\/strong> \u0111\u1ec3 thao t\u00e1c ho\u1eb7c b\u1ea3o qu\u1ea3n hexetidin.<\/p>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh. T\u1ea1o mu\u1ed1i v\u1edbi acid v\u00f4 c\u01a1 v\u00e0 h\u1eefu c\u01a1; acid m\u1ea1nh l\u00e0m m\u1edf v\u00f2ng hexahydropyrimidin, gi\u1ea3i ph\u00f3ng formaldehyd.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Hydro h\u00f3a d\u01b0\u1edbi \u00e1p su\u1ea5t 1,3-bis(2-ethylhexyl)-5-methyl-5-nitrohexahydropyrimidin \u1edf 100 \u00b0C v\u1edbi x\u00fac t\u00e1c niken Raney.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        \u0110\u1ebfn 0,1%, hexetidin \u0111\u01b0\u1ee3c xem l\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; th\u1ec9nh tho\u1ea3ng c\u00f3 b\u00e1o c\u00e1o vi\u00eam da ti\u1ebfp x\u00fac d\u1ecb \u1ee9ng v\u00e0 thay \u0111\u1ed5i c\u1ea3m nh\u1eadn m\u00f9i v\u1ecb. Hexetidin \u0111\u1ed9c khi ti\u00eam t\u0129nh m\u1ea1ch. Dung d\u1ecbch d\u1ea7u 5\u201310% g\u00e2y k\u00edch \u1ee9ng nguy\u00ean ph\u00e1t m\u1ea1nh (kh\u00f4ng g\u00e2y m\u1eabn c\u1ea3m) \u1edf ng\u01b0\u1eddi. Nghi\u00ean c\u1ee9u d\u00e0i h\u1ea1n v\u1edbi 0,1% trong th\u1ee9c \u0103n 1 n\u0103m v\u00e0 nghi\u00ean c\u1ee9u \u0111\u1ed9c t\u00ednh thai tr\u00ean chu\u1ed9t \u0111\u1ebfn 50 mg\/kg\/ng\u00e0y kh\u00f4ng th\u1ea5y \u0111\u1ed9c t\u00ednh. C\u00f3 th\u1ec3 c\u00f3 h\u1ea1i khi h\u00edt ho\u1eb7c ti\u1ebfp x\u00fac da, m\u1eaft \u2013 d\u00f9ng k\u00ednh, g\u0103ng tay; m\u1eb7t n\u1ea1 c\u00f3 phin l\u1ecdc khi thao t\u00e1c l\u01b0\u1ee3ng l\u1edbn.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i ch\u00e2u \u00c2u.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> clorhexidin, cetylpyridinium clorid.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Hexetidine<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Hexetidin \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 s\u00e1t khu\u1ea9n khoang mi\u1ec7ng Hexetidin l\u00e0 ch\u1ea5t kh\u00e1ng khu\u1ea9n ph\u1ed5 r\u1ed9ng kh\u00f4ng thu\u1ed9c nh\u00f3m kh\u00e1ng sinh, d\u1eabn ch\u1ea5t hexahydropyrimidin. Ch\u1ea5t n\u00e0y \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n trong m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam, v\u00e0 quen thu\u1ed9c nh\u1ea5t trong n\u01b0\u1edbc s\u00fac mi\u1ec7ng 0,1% v\u1edbi vai tr\u00f2 s\u00e1t […]<\/p>\n","protected":false},"author":1,"featured_media":2363,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2364","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hexetidin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hexetidin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hexetidin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hexetidin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hexetidin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hexetidin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hexetidin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hexetidin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Hexetidin \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 s\u00e1t khu\u1ea9n khoang mi\u1ec7ng Hexetidin l\u00e0 ch\u1ea5t kh\u00e1ng khu\u1ea9n ph\u1ed5 r\u1ed9ng kh\u00f4ng thu\u1ed9c nh\u00f3m kh\u00e1ng sinh, d\u1eabn ch\u1ea5t hexahydropyrimidin. Ch\u1ea5t n\u00e0y \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n trong m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam, v\u00e0 quen thu\u1ed9c nh\u1ea5t trong n\u01b0\u1edbc s\u00fac mi\u1ec7ng 0,1% v\u1edbi vai tr\u00f2 s\u00e1t…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2364"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2364\/revisions"}],"predecessor-version":[{"id":3838,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2364\/revisions\/3838"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2363"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}