{"id":2352,"date":"2026-09-27T11:32:02","date_gmt":"2026-09-27T04:32:02","guid":{"rendered":"https:\/\/cpc1.vn\/glyceryl-monostearat\/"},"modified":"2026-09-29T12:02:20","modified_gmt":"2026-09-29T05:02:20","slug":"glyceryl-monostearat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/glyceryl-monostearat\/","title":{"rendered":"Glyceryl monostearat (GMS) \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, c\u1ed1t s\u00e1p"},"content":{"rendered":"

Glyceryl monostearat (GMS) \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, c\u1ed1t s\u00e1p<\/h1>\n

Glyceryl monostearat<\/strong> (GMS, glycerol stearat) l\u00e0 t\u00e1 d\u01b0\u1ee3c kh\u00f4ng ion h\u00f3a r\u1ea5t ph\u1ed5 bi\u1ebfn trong th\u1ef1c ph\u1ea9m, d\u01b0\u1ee3c ph\u1ea9m, m\u1ef9 ph\u1ea9m: ch\u1ea5t l\u00e0m m\u1ec1m, ch\u1ea5t \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, ch\u1ea5t ph\u00e2n t\u00e1n, t\u00e1 d\u01b0\u1ee3c tr\u01a1n v\u00e0 th\u00e0nh ph\u1ea7n c\u1ed1t s\u00e1p gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nGlycerol monostearate, glyceryl stearate, monostearin, GMS; Cutina GMS, Imwitor 191\/900, Capmul GMS-50, Myvaplex 600P, Tegin, Lipo GMS\u2026<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n31566-31-1<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC21<\/sub>H42<\/sub>O4<\/sub> \u2013 358,6<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t l\u00e0m m\u1ec1m, nh\u0169 h\u00f3a, h\u00f2a tan, \u1ed5n \u0111\u1ecbnh; th\u00e0nh ph\u1ea7n gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i; t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Hai nh\u00f3m c\u1ea5p ch\u00ednh<\/h2>\n\n\n\n\n\n\n
C\u1ea5p<\/th>\nTh\u00e0nh ph\u1ea7n<\/th>\n<\/tr>\n<\/thead>\n
GMS 40\u201355 (Ph.Eur.) ~ “mono- and diglycerides” (USP-NF)<\/td>\n40\u201355% monoacylglycerol, 30\u201345% diacylglycerol, 5\u201315% triacylglycerol<\/td>\n<\/tr>\n
GMS 90% (USP-NF)<\/td>\n\u2265 90% monoglycerid, ch\u1ee7 y\u1ebfu glyceryl monostearat v\u00e0 monopalmitat<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

C\u00f2n c\u00f3 lo\u1ea1i t\u1ef1 nh\u0169 h\u00f3a<\/strong> ch\u1ee9a m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf x\u00e0 ph\u00f2ng, alcol sulfat h\u00f3a, ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion h\u00f3a ho\u1eb7c amoni b\u1eadc b\u1ed1n \u2013 d\u00f9ng l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a cho d\u1ea7u, m\u1ee1, s\u00e1p (ch\u1ebf ph\u1ea9m n\u01b0\u1edbc c\u1ea7n ch\u1ea5t b\u1ea3o qu\u1ea3n).<\/p>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng \u2013 dung m\u00f4i chung cho ch\u1ea5t ph\u00e2n c\u1ef1c v\u00e0 kh\u00f4ng ph\u00e2n c\u1ef1c; ph\u00e2n t\u00e1n b\u1ed9t m\u00e0u trong d\u1ea7u, ch\u1ea5t r\u1eafn trong m\u1ee1; dung m\u00f4i cho phospholipid nh\u01b0 lecithin.<\/li>\n
  • B\u1ea3n th\u00e2n GMS kh\u00f4ng ph\u1ea3i ch\u1ea5t nh\u0169 h\u00f3a m\u1ea1nh, nh\u01b0ng l\u00e0 ch\u1ea5t l\u00e0m m\u1ec1m d\u1ec5 \u0111\u01b0\u1ee3c nh\u0169 h\u00f3a; th\u00eam v\u00e0o kem gi\u00fap m\u1ecbn, t\u0103ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh; \u00edt l\u00e0m kh\u00f4 da h\u01a1n kem stearat.<\/li>\n
  • T\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n; c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i (pellet, thu\u1ed1c \u0111\u1eb7t, bolus th\u00fa y, d\u1ea1ng c\u1ea5y ph\u00e2n h\u1ee7y sinh h\u1ecdc); t\u1ea1o h\u1ea1t n\u00f3ng ch\u1ea3y t\u1ea7ng s\u00f4i.<\/li>\n
  • L\u01b0u \u00fd d\u1ea1ng th\u00f9 h\u00ecnh<\/strong>: d\u1ea1ng \u03b1 ph\u00e2n t\u00e1n, t\u1ea1o b\u1ecdt \u2013 d\u00f9ng nh\u0169 h\u00f3a; d\u1ea1ng \u03b2 \u0111\u1eb7c, b\u1ec1n h\u01a1n \u2013 ph\u00f9 h\u1ee3p c\u1ed1t s\u00e1p, \u0111\u00e3 d\u00f9ng che v\u1ecb clarithromycin cho tr\u1ebb em.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t r\u1eafn d\u1ea1ng s\u00e1p tr\u1eafng \u0111\u1ebfn m\u00e0u kem (h\u1ea1t, v\u1ea3y, b\u1ed9t), s\u1edd nh\u01b0 s\u00e1p, m\u00f9i v\u1ecb b\u00e9o nh\u1eb9.<\/li>\n
    • N\u00f3ng ch\u1ea3y \u2265 55 \u00b0C (d\u01b0\u1ee3c \u0111i\u1ec3n); ch\u1ec9 s\u1ed1 hydroxyl, ch\u1ec9 s\u1ed1 x\u00e0 ph\u00f2ng h\u00f3a thay \u0111\u1ed5i theo c\u1ea5p.<\/li>\n
    • Nhi\u1ec1u c\u1ea5p \u0111\u01b0\u1ee3c “may \u0111o” theo \u1ee9ng d\u1ee5ng n\u00ean t\u00ednh ch\u1ea5t v\u1eadt l\u00fd kh\u00e1c nhau \u0111\u00e1ng k\u1ec3 gi\u1eefa nh\u00e0 cung c\u1ea5p.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 \u1ea5m l\u00e0m ch\u1ec9 s\u1ed1 acid t\u0103ng d\u1ea7n (x\u00e0 ph\u00f2ng h\u00f3a v\u1edbi v\u1ebft n\u01b0\u1edbc). C\u00f3 th\u1ec3 th\u00eam ch\u1ea5t ch\u1ed1ng oxy h\u00f3a nh\u01b0 BHT, propyl gallat. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      Lo\u1ea1i t\u1ef1 nh\u0169 h\u00f3a t\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t acid.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Glycerin ph\u1ea3n \u1ee9ng v\u1edbi triglycerid ngu\u1ed3n \u0111\u1ed9ng v\u1eadt ho\u1eb7c th\u1ef1c v\u1eadt t\u1ea1o h\u1ed7n h\u1ee3p mono- v\u00e0 diglycerid; diglycerid c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c x\u1eed l\u00fd ti\u1ebfp \u0111\u1ec3 c\u00f3 lo\u1ea1i 90% monoglycerid; ho\u1eb7c cho glycerol ph\u1ea3n \u1ee9ng v\u1edbi stearoyl clorid. S\u1ea3n ph\u1ea9m ch\u1ee9a c\u1ea3 ester palmitat, oleat.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      D\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m, thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i; \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. N\u1ebfu ngu\u1ed3n t\u1eeb m\u1ee1 \u0111\u1ed9ng v\u1eadt (m\u1ee1 b\u00f2) c\u00f3 th\u1ec3 c\u00f3 y\u00eau c\u1ea7u b\u1ed5 sung v\u1ec1 an to\u00e0n BSE.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • FDA x\u1ebfp nh\u00f3m GRAS; c\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean nang, vi\u00ean n\u00e9n u\u1ed1ng; nh\u1ecf m\u1eaft, nh\u1ecf tai, tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, qua da, \u00e2m \u0111\u1ea1o).<\/li>\n
      • C\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong JP, Ph.Eur. v\u00e0 USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> glyceryl monooleat, glyceryl palmitostearat, glyceryl monostearat t\u1ef1 nh\u0169 h\u00f3a.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Glyceryl Monostearate<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Glyceryl monostearat (GMS) \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, c\u1ed1t s\u00e1p Glyceryl monostearat (GMS, glycerol stearat) l\u00e0 t\u00e1 d\u01b0\u1ee3c kh\u00f4ng ion h\u00f3a r\u1ea5t ph\u1ed5 bi\u1ebfn trong th\u1ef1c ph\u1ea9m, d\u01b0\u1ee3c ph\u1ea9m, m\u1ef9 ph\u1ea9m: ch\u1ea5t l\u00e0m m\u1ec1m, ch\u1ea5t \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, ch\u1ea5t ph\u00e2n t\u00e1n, t\u00e1 d\u01b0\u1ee3c tr\u01a1n v\u00e0 th\u00e0nh ph\u1ea7n c\u1ed1t s\u00e1p gi\u1ea3i ph\u00f3ng […]<\/p>\n","protected":false},"author":1,"featured_media":2351,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2352","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-monostearat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-monostearat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-monostearat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-monostearat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-monostearat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-monostearat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-monostearat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-monostearat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Glyceryl monostearat (GMS) \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, c\u1ed1t s\u00e1p Glyceryl monostearat (GMS, glycerol stearat) l\u00e0 t\u00e1 d\u01b0\u1ee3c kh\u00f4ng ion h\u00f3a r\u1ea5t ph\u1ed5 bi\u1ebfn trong th\u1ef1c ph\u1ea9m, d\u01b0\u1ee3c ph\u1ea9m, m\u1ef9 ph\u1ea9m: ch\u1ea5t l\u00e0m m\u1ec1m, ch\u1ea5t \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, ch\u1ea5t ph\u00e2n t\u00e1n, t\u00e1 d\u01b0\u1ee3c tr\u01a1n v\u00e0 th\u00e0nh ph\u1ea7n c\u1ed1t s\u00e1p gi\u1ea3i ph\u00f3ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2352"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2352\/revisions"}],"predecessor-version":[{"id":3829,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2352\/revisions\/3829"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2351"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2352"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2352"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}