{"id":2346,"date":"2026-09-27T11:30:01","date_gmt":"2026-09-27T04:30:01","guid":{"rendered":"https:\/\/cpc1.vn\/glycerin\/"},"modified":"2026-09-28T21:13:02","modified_gmt":"2026-09-28T14:13:02","slug":"glycerin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/glycerin\/","title":{"rendered":"Glycerin (glycerol, E422) \u2013 dung m\u00f4i, ch\u1ea5t gi\u1eef \u1ea9m, ch\u1ea5t h\u00f3a d\u1ebbo"},"content":{"rendered":"

Glycerin (glycerol, E422) \u2013 dung m\u00f4i, ch\u1ea5t gi\u1eef \u1ea9m, ch\u1ea5t h\u00f3a d\u1ebbo<\/h1>\n

Glycerin<\/strong> (glycerol, E422) l\u00e0 alcol ba ch\u1ee9c \u2013 ch\u1ea5t l\u1ecfng s\u00e1nh, ng\u1ecdt, h\u00fat \u1ea9m. \u0110\u00e2y l\u00e0 m\u1ed9t trong nh\u1eefng t\u00e1 d\u01b0\u1ee3c \u0111a n\u0103ng nh\u1ea5t: dung m\u00f4i, ch\u1ea5t gi\u1eef \u1ea9m, l\u00e0m m\u1ec1m, ch\u1ea5t h\u00f3a d\u1ebbo, ch\u1ea5t t\u1ea1o ng\u1ecdt, ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 ch\u1ea5t \u0111\u1eb3ng tr\u01b0\u01a1ng; c\u00f3 m\u1eb7t trong thu\u1ed1c u\u1ed1ng, nh\u1ecf tai, nh\u1ecf m\u1eaft, d\u00f9ng ngo\u00e0i v\u00e0 ti\u00eam.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nGlycerol, glycerine, 1,2,3-propanetriol, E422; Croderol, Glycon G-100, Kemstrene, Optim, Pricerine<\/td>\n<\/tr>\n
T\u00ean h\u00f3a h\u1ecdc<\/td>\nPropan-1,2,3-triol<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n56-81-5<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC3<\/sub>H8<\/sub>O3<\/sub> \u2013 92,09<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n, l\u00e0m m\u1ec1m, gi\u1eef \u1ea9m, h\u00f3a d\u1ebbo, dung m\u00f4i, t\u1ea1o ng\u1ecdt, \u0111\u1eb3ng tr\u01b0\u01a1ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
Vai tr\u00f2<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
Ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/td>\n< 20<\/td>\n<\/tr>\n
Ch\u1ea5t l\u00e0m m\u1ec1m<\/td>\n\u2264 30<\/td>\n<\/tr>\n
Ch\u1ea5t gi\u1eef \u1ea9m<\/td>\n\u2264 30<\/td>\n<\/tr>\n
Ch\u1ebf ph\u1ea9m nh\u1ecf m\u1eaft<\/td>\n0,5\u20133,0<\/td>\n<\/tr>\n
Ch\u1ea5t h\u00f3a d\u1ebbo trong m\u00e0ng bao<\/td>\nthay \u0111\u1ed5i<\/td>\n<\/tr>\n
Dung m\u00f4i cho thu\u1ed1c ti\u00eam<\/td>\n\u2264 50<\/td>\n<\/tr>\n
T\u1ea1o ng\u1ecdt trong c\u1ed3n ng\u1ecdt (elixir)<\/td>\n\u2264 20<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • D\u00f9ng ngo\u00e0i v\u00e0 m\u1ef9 ph\u1ea9m: ch\u1ee7 y\u1ebfu gi\u1eef \u1ea9m v\u00e0 l\u00e0m m\u1ec1m; c\u00f3 trong kem, nh\u0169 t\u01b0\u01a1ng.<\/li>\n
  • Dung d\u1ecbch u\u1ed1ng: dung m\u00f4i, t\u1ea1o ng\u1ecdt (ng\u1ecdt kho\u1ea3ng 0,6 l\u1ea7n saccarose), b\u1ea3o qu\u1ea3n, t\u0103ng \u0111\u1ed9 nh\u1edbt.<\/li>\n
  • Ch\u1ea5t h\u00f3a d\u1ebbo cho gelatin trong v\u1ecf nang m\u1ec1m v\u00e0 thu\u1ed1c \u0111\u1eb7t gelatin; ch\u1ea5t h\u00f3a d\u1ebbo cho m\u00e0ng bao.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t l\u1ecfng trong, kh\u00f4ng m\u00e0u, kh\u00f4ng m\u00f9i, s\u00e1nh, h\u00fat \u1ea9m, v\u1ecb ng\u1ecdt.<\/li>\n
    • N\u00f3ng ch\u1ea3y 17,8 \u00b0C; s\u00f4i 290 \u00b0C (ph\u00e2n h\u1ee7y); \u0111i\u1ec3m ch\u1edbp ch\u00e1y 176 \u00b0C (c\u1ed1c h\u1edf).<\/li>\n
    • T\u1ef7 tr\u1ecdng 1,2636 g\/cm\u00b3 (20 \u00b0C); chi\u1ebft su\u1ea5t nD<\/sub>20<\/sup> 1,4746; s\u1ee9c c\u0103ng b\u1ec1 m\u1eb7t 63,4 mN\/m.<\/li>\n
    • Dung d\u1ecbch 2,6% (tt\/tt) \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh.<\/li>\n
    • Tan trong n\u01b0\u1edbc, ethanol 95%, methanol; tan 1\/11 trong ethyl acetat, 1\/500 trong ether; \u00edt tan trong aceton; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong benzen, cloroform, d\u1ea7u.<\/li>\n
    • \u0110\u1ed9 nh\u1edbt dung d\u1ecbch n\u01b0\u1edbc (20 \u00b0C): 10% \u2013 kho\u1ea3ng 1,3 mPa\u00b7s; 50% \u2013 kho\u1ea3ng 6 mPa\u00b7s; 70% \u2013 kho\u1ea3ng 23 mPa\u00b7s (glycerin nguy\u00ean ch\u1ea5t r\u1ea5t nh\u1edbt, kho\u1ea3ng 1400 mPa\u00b7s).<\/li>\n
    • H\u1ea1 \u0111i\u1ec3m \u0111\u00f4ng m\u1ea1nh: dung d\u1ecbch 60\u201367% \u0111\u00f4ng \u1edf kho\u1ea3ng \u221235 \u0111\u1ebfn \u221246 \u00b0C.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      H\u00fat \u1ea9m. Glycerin tinh khi\u1ebft kh\u00f4ng d\u1ec5 b\u1ecb oxy h\u00f3a trong \u0111i\u1ec1u ki\u1ec7n th\u01b0\u1eddng nh\u01b0ng ph\u00e2n h\u1ee7y khi \u0111un n\u00f3ng, gi\u1ea3i ph\u00f3ng acrolein \u0111\u1ed9c. H\u1ed7n h\u1ee3p v\u1edbi n\u01b0\u1edbc, ethanol, propylen glycol b\u1ec1n v\u1ec1 h\u00f3a h\u1ecdc. C\u00f3 th\u1ec3 k\u1ebft tinh khi b\u1ea3o qu\u1ea3n l\u1ea1nh, tinh th\u1ec3 ch\u1ec9 tan l\u1ea1i khi \u1ea5m l\u00ean kho\u1ea3ng 20 \u00b0C. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • C\u00f3 th\u1ec3 n\u1ed5 khi tr\u1ed9n v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh (crom trioxyd, kali clorat, kali permanganat).<\/li>\n
      • H\u00f3a \u0111en khi g\u1eb7p \u00e1nh s\u00e1ng ho\u1eb7c ti\u1ebfp x\u00fac k\u1ebdm oxyd, bismuth nitrat base.<\/li>\n
      • V\u1ebft s\u1eaft trong glycerin l\u00e0m s\u1eabm m\u00e0u h\u1ed7n h\u1ee3p ch\u1ee9a phenol, salicylat, tannin.<\/li>\n
      • T\u1ea1o ph\u1ee9c v\u1edbi acid boric (acid glyceroboric) \u2013 acid m\u1ea1nh h\u01a1n acid boric.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Ch\u1ee7 y\u1ebfu l\u00e0 s\u1ea3n ph\u1ea9m ph\u1ee5 khi s\u1ea3n xu\u1ea5t x\u00e0 ph\u00f2ng v\u00e0 acid b\u00e9o t\u1eeb d\u1ea7u m\u1ee1; c\u0169ng c\u00f3 th\u1ec3 l\u00ean men (v\u00ed d\u1ee5 r\u1ec9 \u0111\u01b0\u1eddng c\u1ee7 c\u1ea3i v\u1edbi natri sulfit) ho\u1eb7c t\u1ed5ng h\u1ee3p b\u1eb1ng clo h\u00f3a v\u00e0 x\u00e0 ph\u00f2ng h\u00f3a propylen.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        Glycerin c\u00f3 t\u1ef1 nhi\u00ean trong d\u1ea7u m\u1ee1 \u0103n, h\u1ea5p thu d\u1ec5 v\u00e0 chuy\u1ec3n h\u00f3a th\u00e0nh CO2<\/sub>, glycogen ho\u1eb7c d\u00f9ng t\u1ed5ng h\u1ee3p ch\u1ea5t b\u00e9o. T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n ch\u1ee7 y\u1ebfu do t\u00ednh h\u00fat n\u01b0\u1edbc: \u0111\u01b0\u1eddng u\u1ed1ng c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m d\u1ecbu v\u00e0 nhu\u1eadn tr\u00e0ng nh\u1eb9; li\u1ec1u l\u1edbn c\u00f3 th\u1ec3 g\u00e2y \u0111au \u0111\u1ea7u, kh\u00e1t, bu\u1ed3n n\u00f4n, t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft; ti\u00eam t\u0129nh m\u1ea1ch li\u1ec1u r\u1ea5t l\u1edbn nhanh c\u00f3 th\u1ec3 g\u00e2y tan m\u00e1u, suy th\u1eadn. V\u1edbi vai tr\u00f2 t\u00e1 d\u01b0\u1ee3c ho\u1eb7c ph\u1ee5 gia th\u1ef1c ph\u1ea9m, glycerin th\u01b0\u1eddng kh\u00f4ng g\u00e2y t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i. D\u00f9ng k\u00ednh, g\u0103ng tay; gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m s\u01b0\u01a1ng glycerin t\u1ea1i Anh 10 mg\/m\u00b3; ch\u1ea5t ch\u00e1y \u0111\u01b0\u1ee3c.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • FDA x\u1ebfp nh\u00f3m GRAS; \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E422).<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Guide cho g\u1ea7n nh\u01b0 m\u1ecdi \u0111\u01b0\u1eddng d\u00f9ng (nha khoa, ni\u00eam m\u1ea1c m\u00e1, h\u00edt, ti\u00eam, m\u0169i, m\u1eaft, u\u1ed1ng, tai, tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, qua da, \u00e2m \u0111\u1ea1o).<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong JP, Ph.Eur., USP. L\u01b0u \u00fd JP “glycerin” ch\u1ee9a 84\u201387% glycerol; Ph.Eur. c\u00f3 ri\u00eang “glycerol 85%” (83,5\u201388,5%).<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> propylen glycol, sorbitol, polyethylen glycol.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Glycerin<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Glycerin (glycerol, E422) \u2013 dung m\u00f4i, ch\u1ea5t gi\u1eef \u1ea9m, ch\u1ea5t h\u00f3a d\u1ebbo Glycerin (glycerol, E422) l\u00e0 alcol ba ch\u1ee9c \u2013 ch\u1ea5t l\u1ecfng s\u00e1nh, ng\u1ecdt, h\u00fat \u1ea9m. \u0110\u00e2y l\u00e0 m\u1ed9t trong nh\u1eefng t\u00e1 d\u01b0\u1ee3c \u0111a n\u0103ng nh\u1ea5t: dung m\u00f4i, ch\u1ea5t gi\u1eef \u1ea9m, l\u00e0m m\u1ec1m, ch\u1ea5t h\u00f3a d\u1ebbo, ch\u1ea5t t\u1ea1o ng\u1ecdt, ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 ch\u1ea5t \u0111\u1eb3ng […]<\/p>\n","protected":false},"author":1,"featured_media":2345,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2346","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycerin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycerin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycerin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycerin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycerin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycerin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycerin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycerin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Glycerin (glycerol, E422) \u2013 dung m\u00f4i, ch\u1ea5t gi\u1eef \u1ea9m, ch\u1ea5t h\u00f3a d\u1ebbo Glycerin (glycerol, E422) l\u00e0 alcol ba ch\u1ee9c \u2013 ch\u1ea5t l\u1ecfng s\u00e1nh, ng\u1ecdt, h\u00fat \u1ea9m. \u0110\u00e2y l\u00e0 m\u1ed9t trong nh\u1eefng t\u00e1 d\u01b0\u1ee3c \u0111a n\u0103ng nh\u1ea5t: dung m\u00f4i, ch\u1ea5t gi\u1eef \u1ea9m, l\u00e0m m\u1ec1m, ch\u1ea5t h\u00f3a d\u1ebbo, ch\u1ea5t t\u1ea1o ng\u1ecdt, ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 ch\u1ea5t \u0111\u1eb3ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2346"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2346\/revisions"}],"predecessor-version":[{"id":3239,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2346\/revisions\/3239"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2345"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}