{"id":2330,"date":"2026-09-27T11:25:34","date_gmt":"2026-09-27T04:25:34","guid":{"rendered":"https:\/\/cpc1.vn\/ethylcellulose\/"},"modified":"2026-09-28T21:12:26","modified_gmt":"2026-09-28T14:12:26","slug":"ethylcellulose","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/ethylcellulose\/","title":{"rendered":"Ethylcellulose (Ethocel, Surelease) \u2013 m\u00e0ng bao k\u1ef5 n\u01b0\u1edbc gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i"},"content":{"rendered":"

Ethylcellulose (Ethocel, Surelease) \u2013 m\u00e0ng bao k\u1ef5 n\u01b0\u1edbc gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/h1>\n

Ethylcellulose<\/strong> l\u00e0 ether ethyl c\u1ee7a cellulose, polyme k\u1ef5 n\u01b0\u1edbc, kh\u00f4ng tan trong n\u01b0\u1edbc<\/strong>. \u0110\u00e2y l\u00e0 t\u00e1 d\u01b0\u1ee3c bao kinh \u0111i\u1ec3n cho vi\u00ean v\u00e0 pellet gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/strong>, che v\u1ecb, c\u1ea3i thi\u1ec7n \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh; \u0111\u1ed3ng th\u1eddi d\u00f9ng l\u00e0m c\u1ed1t, t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 v\u1ecf vi nang.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nCellulose ethyl ether, E462; Ethocel, Aqualon; d\u1ea1ng ph\u00e2n t\u00e1n n\u01b0\u1edbc: Aquacoat ECD, Surelease<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n9004-57-3<\/td>\n<\/tr>\n
C\u1ea5u t\u1ea1o<\/td>\nChu\u1ed7i \u03b2-anhydroglucose n\u1ed1i b\u1eb1ng li\u00ean k\u1ebft acetal; nh\u00f3m OH \u0111\u01b0\u1ee3c ethyl h\u00f3a, m\u1ee9c th\u1ebf (DS) t\u1ed1i \u0111a 3; h\u00e0m l\u01b0\u1ee3ng ethoxyl 44,0\u201351,0% (d\u01b0\u1ee3c \u0111i\u1ec3n)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nT\u00e1 d\u01b0\u1ee3c bao, ch\u1ea5t c\u1ed1 \u0111\u1ecbnh h\u01b0\u01a1ng, t\u00e1 d\u01b0\u1ee3c d\u00ednh, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n, t\u0103ng \u0111\u1ed9 nh\u1edbt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n\n\n\n\n\n\n\n\n
Vai tr\u00f2<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
Vi nang<\/td>\n10,0\u201320,0<\/td>\n<\/tr>\n
Bao vi\u00ean gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/td>\n3,0\u201320,0<\/td>\n<\/tr>\n
Bao vi\u00ean<\/td>\n1,0\u20133,0<\/td>\n<\/tr>\n
X\u00e1t h\u1ea1t vi\u00ean n\u00e9n<\/td>\n1,0\u20133,0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • M\u00e0ng bao k\u1ef5 n\u01b0\u1edbc<\/strong> cho vi\u00ean v\u00e0 h\u1ea1t: \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, che v\u1ecb, t\u0103ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh (v\u00ed d\u1ee5 bao h\u1ea1t ch\u1ed1ng oxy h\u00f3a). H\u00f2a trong dung m\u00f4i h\u1eefu c\u01a1 t\u1ea1o m\u00e0ng kh\u00f4ng tan trong n\u01b0\u1edbc; c\u1ea5p \u0111\u1ed9 nh\u1edbt cao cho m\u00e0ng b\u1ec1n ch\u1eafc h\u01a1n. C\u00f3 th\u1ec3 th\u00eam hypromellose ho\u1eb7c ch\u1ea5t h\u00f3a d\u1ebbo \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh t\u00ednh th\u1ea5m.<\/li>\n
  • H\u1ec7 ph\u00e2n t\u00e1n n\u01b0\u1edbc (latex)<\/strong> Aquacoat ECD, Surelease \u2013 bao kh\u00f4ng c\u1ea7n dung m\u00f4i h\u1eefu c\u01a1; th\u01b0\u1eddng d\u00f9ng cho h\u1ea1t, pellet (di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t l\u1edbn gi\u00fap khu\u1ebfch t\u00e1n qua m\u00e0ng \u0111\u1ee7 nhanh). H\u1ea1t bao ethylcellulose c\u00f2n h\u1ea5p thu \u00e1p l\u1ef1c, b\u1ea3o v\u1ec7 m\u00e0ng khi d\u1eadp vi\u00ean.<\/li>\n
  • C\u1ed1t gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i<\/strong>; vi nang<\/strong> (c\u1ea5p \u0111\u1ed9 nh\u1edbt cao) \u2013 t\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng ph\u1ee5 thu\u1ed9c b\u1ec1 d\u00e0y th\u00e0nh v\u00e0 di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t.<\/li>\n
  • T\u00e1 d\u01b0\u1ee3c d\u00ednh: tr\u1ed9n kh\u00f4 ho\u1eb7c x\u00e1t h\u1ea1t v\u1edbi ethanol 95% \u2013 vi\u00ean c\u1ee9ng, \u00edt b\u1edf nh\u01b0ng c\u00f3 th\u1ec3 h\u00f2a tan k\u00e9m.<\/li>\n
  • D\u00f9ng ngo\u00e0i: l\u00e0m \u0111\u1eb7c kem, lotion, gel (v\u1edbi dung m\u00f4i ph\u00f9 h\u1ee3p); \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng; m\u00e0ng l\u00f3t mi\u1ebfng d\u00e1n ni\u00eam m\u1ea1c m\u00e1.<\/li>\n<\/ul>\n

    Ch\u1ea5t h\u00f3a d\u1ebbo t\u01b0\u01a1ng h\u1ee3p<\/h2>\n

    Dibutyl phthalat, diethyl phthalat, dibutyl sebacat, triethyl citrat, tributyl citrat, acetyltributyl citrat, triacetin, monoglycerid acetyl h\u00f3a, dimethyl phthalat, benzyl benzoat, ester acid b\u00e9o, d\u1ea7u kho\u00e1ng tinh ch\u1ebf, acid oleic, acid stearic, alcol stearylic, d\u1ea7u th\u1ea7u d\u1ea7u, d\u1ea7u ng\u00f4, long n\u00e3o\u2026<\/p>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u01a1n ch\u1ea3y, tr\u1eafng \u0111\u1ebfn n\u00e2u nh\u1ea1t, kh\u00f4ng v\u1ecb.<\/li>\n
    • T\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn kho\u1ea3ng 0,4 g\/cm\u00b3; nhi\u1ec7t \u0111\u1ed9 h\u00f3a th\u1ee7y tinh 129\u2013133 \u00b0C.<\/li>\n
    • H\u00fat r\u1ea5t \u00edt n\u01b0\u1edbc t\u1eeb kh\u00f4ng kh\u00ed \u1ea9m, l\u01b0\u1ee3ng nh\u1ecf \u0111\u00f3 c\u0169ng bay h\u01a1i d\u1ec5.<\/li>\n
    • Kh\u00f4ng tan trong n\u01b0\u1edbc, glycerin, propylen glycol; tan trong nhi\u1ec1u dung m\u00f4i h\u1eefu c\u01a1 (ethanol, cloroform, ester, hydrocarbon th\u01a1m) t\u00f9y m\u1ee9c th\u1ebf.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n, h\u01a1i h\u00fat \u1ea9m. B\u1ec1n v\u1edbi ki\u1ec1m (lo\u00e3ng v\u00e0 \u0111\u1eb7c) v\u00e0 dung d\u1ecbch mu\u1ed1i, nh\u01b0ng nh\u1ea1y v\u1edbi acid h\u01a1n c\u00e1c ester cellulose. B\u1ecb oxy h\u00f3a khi g\u1eb7p \u00e1nh n\u1eafng\/UV \u1edf nhi\u1ec7t \u0111\u1ed9 cao \u2013 d\u00f9ng ch\u1ea5t ch\u1ed1ng oxy h\u00f3a v\u00e0 ch\u1ea5t h\u1ea5p thu v\u00f9ng 230\u2013340 nm. B\u1ea3o qu\u1ea3n kh\u00f4ng qu\u00e1 32 \u00b0C, kh\u00f4 r\u00e1o, xa ngu\u1ed3n nhi\u1ec7t, kh\u00f4ng \u0111\u1ec3 c\u1ea1nh peroxid v\u00e0 ch\u1ea5t oxy h\u00f3a.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi s\u00e1p parafin v\u00e0 s\u00e1p vi tinh th\u1ec3.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cellulose tinh khi\u1ebft (x\u01a1 b\u00f4ng, b\u1ed9t g\u1ed7) x\u1eed l\u00fd b\u1eb1ng ki\u1ec1m, sau \u0111\u00f3 ethyl h\u00f3a cellulose ki\u1ec1m b\u1eb1ng cloroethan (RONa + C2<\/sub>H5<\/sub>Cl \u2192 ROC2<\/sub>H5<\/sub> + NaCl).<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      D\u00f9ng r\u1ed9ng r\u00e3i trong thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i, th\u1ef1c ph\u1ea9m; kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a khi u\u1ed1ng n\u00ean kh\u00f4ng cung c\u1ea5p n\u0103ng l\u01b0\u1ee3ng; \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng g\u00e2y d\u1ecb \u1ee9ng, kh\u00f4ng k\u00edch \u1ee9ng; WHO kh\u00f4ng quy \u0111\u1ecbnh ADI. Do kh\u00f4ng chuy\u1ec3n h\u00f3a, kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam<\/strong> (c\u00f3 th\u1ec3 h\u1ea1i th\u1eadn). Ch\u1ea5t ch\u00e1y \u0111\u01b0\u1ee3c \u2013 tr\u00e1nh b\u1ee5i m\u1ecbn \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 n\u1ed5; b\u1ed9t c\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • FDA x\u1ebfp nh\u00f3m GRAS; \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E462).<\/li>\n
      • C\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean nang, h\u1ed7n d\u1ecbch, vi\u00ean n\u00e9n u\u1ed1ng; nh\u0169 t\u01b0\u01a1ng d\u00f9ng ngo\u00e0i; \u00e2m \u0111\u1ea1o); c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> hydroxyethyl cellulose, hydroxyethylmethyl cellulose, methylcellulose, hypromellose.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Ethylcellulose<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Ethylcellulose (Ethocel, Surelease) \u2013 m\u00e0ng bao k\u1ef5 n\u01b0\u1edbc gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Ethylcellulose l\u00e0 ether ethyl c\u1ee7a cellulose, polyme k\u1ef5 n\u01b0\u1edbc, kh\u00f4ng tan trong n\u01b0\u1edbc. \u0110\u00e2y l\u00e0 t\u00e1 d\u01b0\u1ee3c bao kinh \u0111i\u1ec3n cho vi\u00ean v\u00e0 pellet gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i, che v\u1ecb, c\u1ea3i thi\u1ec7n \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh; \u0111\u1ed3ng th\u1eddi d\u00f9ng l\u00e0m c\u1ed1t, t\u00e1 d\u01b0\u1ee3c d\u00ednh […]<\/p>\n","protected":false},"author":1,"featured_media":2329,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethylcellulose.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethylcellulose-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethylcellulose-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethylcellulose-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethylcellulose-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethylcellulose.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethylcellulose.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethylcellulose-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Ethylcellulose (Ethocel, Surelease) \u2013 m\u00e0ng bao k\u1ef5 n\u01b0\u1edbc gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Ethylcellulose l\u00e0 ether ethyl c\u1ee7a cellulose, polyme k\u1ef5 n\u01b0\u1edbc, kh\u00f4ng tan trong n\u01b0\u1edbc. \u0110\u00e2y l\u00e0 t\u00e1 d\u01b0\u1ee3c bao kinh \u0111i\u1ec3n cho vi\u00ean v\u00e0 pellet gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i, che v\u1ecb, c\u1ea3i thi\u1ec7n \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh; \u0111\u1ed3ng th\u1eddi d\u00f9ng l\u00e0m c\u1ed1t, t\u00e1 d\u01b0\u1ee3c d\u00ednh…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2330"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2330\/revisions"}],"predecessor-version":[{"id":3232,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2330\/revisions\/3232"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2329"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2330"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2330"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}