{"id":2326,"date":"2026-09-27T11:24:29","date_gmt":"2026-09-27T04:24:29","guid":{"rendered":"https:\/\/cpc1.vn\/ethyl-oleat\/"},"modified":"2026-09-28T21:12:15","modified_gmt":"2026-09-28T14:12:15","slug":"ethyl-oleat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/ethyl-oleat\/","title":{"rendered":"Ethyl oleat \u2013 ch\u1ea5t d\u1eabn d\u1ea7u cho thu\u1ed1c ti\u00eam b\u1eafp, dung m\u00f4i steroid"},"content":{"rendered":"

Ethyl oleat \u2013 ch\u1ea5t d\u1eabn d\u1ea7u cho thu\u1ed1c ti\u00eam b\u1eafp, dung m\u00f4i steroid<\/h1>\n

Ethyl oleat<\/strong> l\u00e0 ester c\u1ee7a ethanol v\u1edbi acid b\u00e9o cao ph\u00e2n t\u1eed, ch\u1ee7 y\u1ebfu acid oleic. Trong b\u00e0o ch\u1ebf, ethyl oleat l\u00e0 ch\u1ea5t d\u1eabn d\u1ea1ng d\u1ea7u cho thu\u1ed1c ti\u00eam b\u1eafp<\/strong> \u2013 t\u00ednh ch\u1ea5t gi\u1ed1ng d\u1ea7u h\u1ea1nh nh\u00e2n, d\u1ea7u l\u1ea1c nh\u01b0ng \u00edt nh\u1edbt h\u01a1n nhi\u1ec1u<\/strong> v\u00e0 \u0111\u01b0\u1ee3c m\u00f4 h\u1ea5p thu nhanh h\u01a1n.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nEthyl 9-octadecenoate, oleic acid ethyl ester, Kessco EO<\/td>\n<\/tr>\n
T\u00ean h\u00f3a h\u1ecdc<\/td>\nEthyl ester c\u1ee7a acid (Z)-9-octadecenoic<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n111-62-6<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC20<\/sub>H38<\/sub>O2<\/sub> \u2013 310,51<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t d\u1eabn d\u1ea1ng d\u1ea7u, dung m\u00f4i<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t d\u1eabn trong thu\u1ed1c ti\u00eam b\u1eafp; \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 cho thu\u1ed1c ti\u00eam d\u01b0\u1edbi da.<\/li>\n
  • Dung m\u00f4i ph\u00f9 h\u1ee3p cho steroid v\u00e0 ho\u1ea1t ch\u1ea5t th\u00e2n d\u1ea7u.<\/li>\n
  • Dung m\u00f4i trong nang ph\u00e2n h\u1ee7y sinh h\u1ecdc c\u1ea5y d\u01b0\u1edbi da; vi nh\u0169 t\u01b0\u01a1ng ch\u1ee9a ciclosporin.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t l\u1ecfng d\u1ea1ng d\u1ea7u linh \u0111\u1ed9ng, v\u00e0ng nh\u1ea1t \u0111\u1ebfn g\u1ea7n kh\u00f4ng m\u00e0u; v\u1ecb gi\u1ed1ng d\u1ea7u \u00f4 liu, m\u00f9i nh\u1eb9 kh\u00f4ng \u00f4i. USP-NF: c\u00f3 th\u1ec3 ch\u1ee9a ch\u1ea5t ch\u1ed1ng oxy h\u00f3a th\u00edch h\u1ee3p.<\/li>\n
    • T\u1ef7 tr\u1ecdng 0,866\u20130,874; chi\u1ebft su\u1ea5t 1,443\u20131,450; ch\u1ec9 s\u1ed1 iod 75\u201390; ch\u1ec9 s\u1ed1 x\u00e0 ph\u00f2ng h\u00f3a 177\u2013188.<\/li>\n
    • \u0110\u1ed9 nh\u1edbt ch\u1ec9 kho\u1ea3ng 3,9 mPa\u00b7s \u1edf 25 \u00b0C (d\u1ea7u b\u00e9o th\u01b0\u1eddng v\u00e0i ch\u1ee5c mPa\u00b7s).<\/li>\n
    • S\u00f4i 205\u2013208 \u00b0C (ph\u00e2n h\u1ee7y m\u1ed9t ph\u1ea7n); \u0111\u00f4ng \u0111\u1eb7c kho\u1ea3ng \u221232 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 175 \u00b0C.<\/li>\n
    • Tr\u1ed9n l\u1eabn v\u1edbi cloroform, ethanol 95%, ether, d\u1ea7u b\u00e9o, parafin l\u1ecfng v\u00e0 ph\u1ea7n l\u1edbn dung m\u00f4i h\u1eefu c\u01a1; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • B\u1ecb oxy h\u00f3a khi ti\u1ebfp x\u00fac kh\u00f4ng kh\u00ed (t\u0103ng ch\u1ec9 s\u1ed1 peroxid); v\u1eabn trong \u1edf 5 \u00b0C nh\u01b0ng s\u1eabm m\u00e0u khi \u0111\u1ec3 l\u00e2u.<\/li>\n
      • B\u1ea3o qu\u1ea3n trong bao b\u00ec nh\u1ecf, \u0111\u1ea7y, k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t; khi d\u00f9ng d\u1edf n\u00ean thay kh\u00f4ng kh\u00ed b\u1eb1ng nit\u01a1 ho\u1eb7c kh\u00ed tr\u01a1.<\/li>\n
      • Ch\u1ea5t ch\u1ed1ng oxy h\u00f3a k\u00e9o d\u00e0i h\u1ea1n d\u00f9ng: \u0111\u1ef1ng chai th\u1ee7y tinh m\u00e0u h\u1ed5 ph\u00e1ch k\u00e8m t\u1ed5 h\u1ee3p propyl gallat, BHA, BHT v\u00e0 acid citric\/ascorbic gi\u00fap b\u1ea3o v\u1ec7 tr\u00ean 2 n\u0103m; h\u1ed7n h\u1ee3p t\u1ed1i \u01b0u \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 0,03% (propyl gallat 37,5% + BHT 37,5% + BHA 25%).<\/li>\n
      • Ti\u1ec7t khu\u1ea9n b\u1eb1ng nhi\u1ec7t kh\u00f4 150 \u00b0C trong 1 gi\u1edd.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        H\u00f2a tan m\u1ed9t s\u1ed1 lo\u1ea1i cao su v\u00e0 l\u00e0m tr\u01b0\u01a1ng c\u00e1c lo\u1ea1i kh\u00e1c \u2013 ch\u1ecdn n\u00fat, \u1ed1ng b\u01a1m ph\u00f9 h\u1ee3p; c\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng v\u1edbi ch\u1ea5t oxy h\u00f3a.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        \u0110\u1ed9c t\u00ednh th\u1ea5p, nh\u01b0ng n\u00ean tr\u00e1nh nu\u1ed1t; g\u00e2y k\u00edch \u1ee9ng m\u00f4 r\u1ea5t nh\u1eb9, ch\u01b0a ghi nh\u1eadn k\u00edch \u1ee9ng khi ti\u00eam b\u1eafp. D\u00f9ng k\u00ednh v\u00e0 g\u0103ng nitril; ethyl oleat ch\u00e1y \u0111\u01b0\u1ee3c.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Guide (ch\u1ebf ph\u1ea9m qua da).<\/li>\n
        • C\u00f3 trong thu\u1ed1c ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> methyl oleat (CAS 112-69-9), acid oleic, isopropyl myristat.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Ethyl Oleate<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Ethyl oleat \u2013 ch\u1ea5t d\u1eabn d\u1ea7u cho thu\u1ed1c ti\u00eam b\u1eafp, dung m\u00f4i steroid Ethyl oleat l\u00e0 ester c\u1ee7a ethanol v\u1edbi acid b\u00e9o cao ph\u00e2n t\u1eed, ch\u1ee7 y\u1ebfu acid oleic. Trong b\u00e0o ch\u1ebf, ethyl oleat l\u00e0 ch\u1ea5t d\u1eabn d\u1ea1ng d\u1ea7u cho thu\u1ed1c ti\u00eam b\u1eafp \u2013 t\u00ednh ch\u1ea5t gi\u1ed1ng d\u1ea7u h\u1ea1nh nh\u00e2n, d\u1ea7u l\u1ea1c nh\u01b0ng \u00edt nh\u1edbt […]<\/p>\n","protected":false},"author":1,"featured_media":2325,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2326","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethyl-oleat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethyl-oleat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethyl-oleat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethyl-oleat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethyl-oleat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethyl-oleat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethyl-oleat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/ethyl-oleat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Ethyl oleat \u2013 ch\u1ea5t d\u1eabn d\u1ea7u cho thu\u1ed1c ti\u00eam b\u1eafp, dung m\u00f4i steroid Ethyl oleat l\u00e0 ester c\u1ee7a ethanol v\u1edbi acid b\u00e9o cao ph\u00e2n t\u1eed, ch\u1ee7 y\u1ebfu acid oleic. Trong b\u00e0o ch\u1ebf, ethyl oleat l\u00e0 ch\u1ea5t d\u1eabn d\u1ea1ng d\u1ea7u cho thu\u1ed1c ti\u00eam b\u1eafp \u2013 t\u00ednh ch\u1ea5t gi\u1ed1ng d\u1ea7u h\u1ea1nh nh\u00e2n, d\u1ea7u l\u1ea1c nh\u01b0ng \u00edt nh\u1edbt…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2326"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2326\/revisions"}],"predecessor-version":[{"id":3230,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2326\/revisions\/3230"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2325"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}