{"id":2306,"date":"2026-09-27T11:18:43","date_gmt":"2026-09-27T04:18:43","guid":{"rendered":"https:\/\/cpc1.vn\/dimethyl-sulfoxyd-dmso\/"},"modified":"2026-09-27T11:18:43","modified_gmt":"2026-09-27T04:18:43","slug":"dimethyl-sulfoxyd-dmso","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/dimethyl-sulfoxyd-dmso\/","title":{"rendered":"Dimethyl sulfoxyd (DMSO) \u2013 dung m\u00f4i ph\u00e2n c\u1ef1c, ch\u1ea5t t\u0103ng th\u1ea5m qua da"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Dimethyl sulfoxyd (DMSO) \u2013 dung m\u00f4i ph\u00e2n c\u1ef1c, ch\u1ea5t t\u0103ng th\u1ea5m qua da<\/h1>\n<p><strong>Dimethyl sulfoxyd<\/strong> (DMSO) l\u00e0 dung m\u00f4i <strong>ph\u00e2n c\u1ef1c kh\u00f4ng proton<\/strong> c\u00f3 kh\u1ea3 n\u0103ng h\u00f2a tan \u0111\u1eb7c bi\u1ec7t m\u1ea1nh v\u1edbi c\u1ea3 ch\u1ea5t h\u1eefu c\u01a1 v\u00e0 v\u00f4 c\u01a1. Trong b\u00e0o ch\u1ebf, DMSO l\u00e0 dung m\u00f4i v\u00e0 <strong>ch\u1ea5t t\u0103ng th\u1ea5m qua da<\/strong>.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean h\u00f3a h\u1ecdc<\/td>\n<td>Sulfinylbismethan<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>67-68-5<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>2<\/sub>H<sub>6<\/sub>OS \u2013 78,13<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t t\u0103ng th\u1ea5m, dung m\u00f4i<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li><strong>Dung m\u00f4i<\/strong>: h\u00f2a tan t\u1ed1t nh\u1edd li\u00ean k\u1ebft \u0111\u01b0\u1ee3c v\u1edbi c\u1ea3 ion v\u00e0 ph\u00e2n t\u1eed trung h\u00f2a ph\u00e2n c\u1ef1c ho\u1eb7c ph\u00e2n c\u1ef1c h\u00f3a \u0111\u01b0\u1ee3c.<\/li>\n<li><strong>T\u0103ng th\u1ea5m qua da<\/strong>: \u0111\u1ea9y n\u01b0\u1edbc li\u00ean k\u1ebft kh\u1ecfi l\u1edbp s\u1eebng, k\u00e8m chi\u1ebft lipid v\u00e0 thay \u0111\u1ed5i c\u1ea5u h\u00ecnh protein. Pha lo\u00e3ng l\u00e0m m\u1ea5t ph\u1ea7n l\u1edbn t\u00e1c d\u1ee5ng: c\u00f3 t\u0103ng th\u1ea5m t\u1eeb kho\u1ea3ng 15%, nh\u01b0ng t\u0103ng r\u00f5 th\u01b0\u1eddng c\u1ea7n <strong>tr\u00ean 60\u201380%<\/strong>. Ph\u00e2n t\u1eed nh\u1ecf th\u1ea5m nhanh v\u00e0o l\u1edbp s\u00e2u, c\u00f2n ph\u00e2n t\u1eed tr\u00ean kho\u1ea3ng 3000 Da kh\u00f3 th\u1ea5m.<\/li>\n<li>\u0110\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u cho \u0111\u01b0a thu\u1ed1c qua da (ciclosporin, timolol\u2026), thu\u1ed1c ti\u00eam (allopurinol) v\u00e0 ch\u1ebf ph\u1ea9m ti\u00eam th\u1eed nghi\u1ec7m.<\/li>\n<li>Ngo\u00e0i vai tr\u00f2 t\u00e1 d\u01b0\u1ee3c, DMSO c\u00f2n l\u00e0 ho\u1ea1t ch\u1ea5t trong m\u1ed9t s\u1ed1 ch\u1ebf ph\u1ea9m t\u1ea1i v\u00e0i n\u01b0\u1edbc (dung d\u1ecbch r\u1eeda b\u00e0ng quang 50% \u1edf M\u1ef9, gel 10% d\u00f9ng ngo\u00e0i \u1edf \u0110\u1ee9c\u2026).<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Ch\u1ea5t l\u1ecfng s\u00e1nh kh\u00f4ng m\u00e0u ho\u1eb7c tinh th\u1ec3 kh\u00f4ng m\u00e0u (n\u00f3ng ch\u1ea3y kho\u1ea3ng 18,5 \u00b0C); v\u1ecb h\u01a1i \u0111\u1eafng r\u1ed3i ng\u1ecdt; kh\u00f4ng m\u00f9i ho\u1eb7c m\u00f9i nh\u1eb9 \u0111\u1eb7c tr\u01b0ng.<\/li>\n<li><strong>C\u1ef1c k\u1ef3 h\u00fat \u1ea9m<\/strong>: h\u00fat \u0111\u1ebfn 70% kh\u1ed1i l\u01b0\u1ee3ng n\u01b0\u1edbc, t\u1ecfa nhi\u1ec7t.<\/li>\n<li>Nhi\u1ec7t \u0111\u1ed9 s\u00f4i 189 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 95 \u00b0C (c\u1ed1c h\u1edf); h\u1eb1ng s\u1ed1 \u0111i\u1ec7n m\u00f4i 48,9; momen l\u01b0\u1ee1ng c\u1ef1c 4,3 D.<\/li>\n<li>Tr\u1ed9n l\u1eabn v\u1edbi n\u01b0\u1edbc (t\u1ecfa nhi\u1ec7t), ethanol, ether v\u00e0 ph\u1ea7n l\u1edbn dung m\u00f4i h\u1eefu c\u01a1; kh\u00f4ng tr\u1ed9n l\u1eabn v\u1edbi parafin, hydrocarbon.<\/li>\n<li>\u0110\u1ed9 nh\u1edbt kho\u1ea3ng 1,1 mPa\u00b7s (27 \u00b0C).<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>Kh\u00e1 b\u1ec1n nhi\u1ec7t, nh\u01b0ng \u0111un h\u1ed3i l\u01b0u l\u00e2u b\u1ecb ph\u00e2n h\u1ee7y nh\u1eb9 th\u00e0nh methyl mercaptan v\u00e0 bismethylthiomethan (acid th\u00fac \u0111\u1ea9y, base l\u00e0m ch\u1eadm); \u1edf 40\u201360 \u00b0C c\u00f3 b\u00e1o c\u00e1o ph\u00e2n h\u1ee7y m\u1ed9t ph\u1ea7n (thay \u0111\u1ed5i chi\u1ebft su\u1ea5t, t\u1ef7 tr\u1ecdng, \u0111\u1ed9 nh\u1edbt). Ph\u00e2n h\u1ee7y nhi\u1ec7t t\u1ea1o kh\u00f3i \u0111\u1ed9c. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, tr\u00e1nh \u00e1nh s\u00e1ng; Ph.Eur. y\u00eau c\u1ea7u <strong>chai th\u1ee7y tinh, tr\u00e1nh ti\u1ebfp x\u00fac nh\u1ef1a<\/strong>.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>C\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng v\u1edbi ch\u1ea5t oxy h\u00f3a.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Oxy h\u00f3a dimethyl sulfid b\u1eb1ng kh\u00f4ng kh\u00ed c\u00f3 x\u00fac t\u00e1c nit\u01a1 oxyd; ho\u1eb7c thu nh\u01b0 s\u1ea3n ph\u1ea9m ph\u1ee5 c\u1ee7a c\u00f4ng nghi\u1ec7p b\u1ed9t gi\u1ea5y.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>DMSO c\u00f3 \u0111\u1ed9c t\u00ednh to\u00e0n th\u00e2n th\u1ea5p nh\u01b0ng g\u00e2y t\u00e1c d\u1ee5ng t\u1ea1i ch\u1ed7: l\u00e0 ch\u1ea5t k\u00edch \u1ee9ng nguy\u00ean ph\u00e1t tr\u00ean da (\u0111\u1ecf, r\u00e1t, ng\u1ee9a, bong v\u1ea3y, m\u00e0y \u0111ay). H\u1ea5p thu d\u1ec5 qua m\u1ecdi \u0111\u01b0\u1eddng d\u00f9ng v\u00e0 ph\u00e2n b\u1ed1 r\u1ed9ng; tri\u1ec7u ch\u1ee9ng to\u00e0n th\u00e2n c\u00f3 th\u1ec3 g\u1ed3m bu\u1ed3n n\u00f4n, n\u00f4n, \u1edbn l\u1ea1nh, chu\u1ed9t r\u00fat, m\u1ec7t; c\u00f3 th\u1ec3 t\u0103ng nh\u00e3n \u00e1p; h\u01a1i th\u1edf c\u00f3 <strong>m\u00f9i t\u1ecfi<\/strong> sau khi d\u00f9ng. V\u00ec t\u0103ng th\u1ea5m qua da, DMSO c\u00f3 th\u1ec3 l\u00e0m t\u0103ng h\u1ea5p thu \u2013 v\u00e0 t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i \u2013 c\u1ee7a c\u00e1c ch\u1ea5t kh\u00e1c c\u00f9ng ti\u1ebfp x\u00fac. T\u1eebng c\u00f3 lo ng\u1ea1i v\u1ec1 thay \u0111\u1ed5i chi\u1ebft su\u1ea5t th\u1ee7y tinh th\u1ec3 \u1edf \u0111\u1ed9ng v\u1eadt (FDA t\u1ea1m d\u1eebng nghi\u00ean c\u1ee9u n\u0103m 1965, sau \u0111\u00f3 n\u1edbi l\u1ecfng d\u1ea7n). D\u00f9ng g\u0103ng tay (ch\u1ecdn lo\u1ea1i ch\u1ecbu DMSO) v\u00e0 k\u00ednh.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (d\u1ecbch truy\u1ec1n t\u0129nh m\u1ea1ch, que c\u1ea5y d\u01b0\u1edbi da, ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i).<\/li>\n<li>C\u00f3 trong thu\u1ed1c d\u00f9ng ngo\u00e0i \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p \u1edf m\u1ed9t s\u1ed1 n\u01b0\u1edbc.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> dimethylacetamid, N-methyl-2-pyrrolidon, 2-pyrrolidon.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Dimethyl Sulfoxide<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Dimethyl sulfoxyd (DMSO) \u2013 dung m\u00f4i ph\u00e2n c\u1ef1c, ch\u1ea5t t\u0103ng th\u1ea5m qua da Dimethyl sulfoxyd (DMSO) l\u00e0 dung m\u00f4i ph\u00e2n c\u1ef1c kh\u00f4ng proton c\u00f3 kh\u1ea3 n\u0103ng h\u00f2a tan \u0111\u1eb7c bi\u1ec7t m\u1ea1nh v\u1edbi c\u1ea3 ch\u1ea5t h\u1eefu c\u01a1 v\u00e0 v\u00f4 c\u01a1. Trong b\u00e0o ch\u1ebf, DMSO l\u00e0 dung m\u00f4i v\u00e0 ch\u1ea5t t\u0103ng th\u1ea5m qua da. Th\u00f4ng tin nhanh [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2305,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2306","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-sulfoxyd-dmso.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-sulfoxyd-dmso-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-sulfoxyd-dmso-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-sulfoxyd-dmso-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-sulfoxyd-dmso-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-sulfoxyd-dmso.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-sulfoxyd-dmso.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-sulfoxyd-dmso-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Dimethyl sulfoxyd (DMSO) \u2013 dung m\u00f4i ph\u00e2n c\u1ef1c, ch\u1ea5t t\u0103ng th\u1ea5m qua da Dimethyl sulfoxyd (DMSO) l\u00e0 dung m\u00f4i ph\u00e2n c\u1ef1c kh\u00f4ng proton c\u00f3 kh\u1ea3 n\u0103ng h\u00f2a tan \u0111\u1eb7c bi\u1ec7t m\u1ea1nh v\u1edbi c\u1ea3 ch\u1ea5t h\u1eefu c\u01a1 v\u00e0 v\u00f4 c\u01a1. Trong b\u00e0o ch\u1ebf, DMSO l\u00e0 dung m\u00f4i v\u00e0 ch\u1ea5t t\u0103ng th\u1ea5m qua da. Th\u00f4ng tin nhanh&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2306","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2306"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2306\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2305"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2306"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2306"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2306"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}