{"id":2294,"date":"2026-09-27T11:15:40","date_gmt":"2026-09-27T04:15:40","guid":{"rendered":"https:\/\/cpc1.vn\/diethanolamin\/"},"modified":"2026-09-29T11:59:24","modified_gmt":"2026-09-29T04:59:24","slug":"diethanolamin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/diethanolamin\/","title":{"rendered":"Diethanolamin (DEA) \u2013 ch\u1ea5t ki\u1ec1m h\u00f3a, \u0111\u1ec7m, nh\u0169 h\u00f3a"},"content":{"rendered":"

Diethanolamin (DEA) \u2013 ch\u1ea5t ki\u1ec1m h\u00f3a, \u0111\u1ec7m, nh\u0169 h\u00f3a<\/h1>\n

Diethanolamin<\/strong> (DEA, diolamin) l\u00e0 amin b\u1eadc hai c\u00f3 hai nh\u00f3m hydroxyl. Trong d\u01b0\u1ee3c ph\u1ea9m, DEA ch\u1ee7 y\u1ebfu l\u00e0m ch\u1ea5t \u0111\u1ec7m, \u0111i\u1ec1u ch\u1ec9nh pH<\/strong>, t\u1ea1o nh\u0169 t\u01b0\u01a1ng v\u1edbi acid b\u00e9o (t\u1ea1o x\u00e0 ph\u00f2ng amin t\u1ea1i ch\u1ed7) v\u00e0 t\u1ea1o mu\u1ed1i tan cho m\u1ed9t s\u1ed1 ho\u1ea1t ch\u1ea5t c\u00f3 t\u00ednh acid.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nDEA, diolamine, bis(hydroxyethyl)amine, diethylolamine, 2,2′-iminodiethanol<\/td>\n<\/tr>\n
T\u00ean h\u00f3a h\u1ecdc<\/td>\n2,2′-Iminobisethanol<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n111-42-2<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC4<\/sub>H11<\/sub>NO2<\/sub> \u2013 105,14<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ki\u1ec1m h\u00f3a, ch\u1ea5t nh\u0169 h\u00f3a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t \u0111\u1ec7m, v\u00ed d\u1ee5 khi b\u00e0o ch\u1ebf nh\u0169 t\u01b0\u01a1ng v\u1edbi acid b\u00e9o; \u0111i\u1ec1u ch\u1ec9nh pH v\u00e0 ch\u1ea5t ph\u00e2n t\u00e1n trong m\u1ef9 ph\u1ea9m, d\u01b0\u1ee3c ph\u1ea9m.<\/li>\n
  • T\u1ea1o mu\u1ed1i tan c\u1ee7a ho\u1ea1t ch\u1ea5t, v\u00ed d\u1ee5 c\u00e1c acid h\u1eefu c\u01a1 iod h\u00f3a d\u00f9ng l\u00e0m thu\u1ed1c c\u1ea3n quang.<\/li>\n
  • Ch\u1ea5t \u1ed5n \u0111\u1ecbnh: ng\u0103n \u0111\u1ed5i m\u00e0u dung d\u1ecbch n\u01b0\u1edbc ch\u1ee9a mu\u1ed1i hexamethylentetramin-1,3-dicloropropen.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • USP-NF m\u00f4 t\u1ea3 l\u00e0 h\u1ed7n h\u1ee3p ethanolamin, ch\u1ee7 y\u1ebfu diethanolamin. \u1ede kho\u1ea3ng nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng l\u00e0 ch\u1ea5t r\u1eafn tr\u1eafng ch\u1ea3y r\u1eefa; tr\u00ean nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng l\u00e0 ch\u1ea5t l\u1ecfng s\u00e1nh, trong, m\u00f9i amoniac nh\u1eb9.<\/li>\n
    • N\u00f3ng ch\u1ea3y 28 \u00b0C; s\u00f4i 268,8 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 138 \u00b0C (c\u1ed1c h\u1edf).<\/li>\n
    • pH dung d\u1ecbch 0,1 N: 11,0; pKa 8,88.<\/li>\n
    • R\u1ea5t h\u00fat \u1ea9m; \u0111\u1ed9 nh\u1edbt kho\u1ea3ng 352 mPa\u00b7s \u1edf 30 \u00b0C.<\/li>\n
    • Tr\u1ed9n l\u1eabn v\u1edbi n\u01b0\u1edbc, aceton, glycerin, methanol, cloroform; tan 1\/24 trong benzen, 1\/125 trong ether.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      H\u00fat \u1ea9m, nh\u1ea1y v\u1edbi \u00e1nh s\u00e1ng v\u00e0 oxy. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • C\u00f3 c\u00e1c ph\u1ea3n \u1ee9ng \u0111\u1eb7c tr\u01b0ng c\u1ee7a amin b\u1eadc hai v\u00e0 alcol; nh\u00f3m amin th\u01b0\u1eddng ph\u1ea3n \u1ee9ng m\u1ea1nh h\u01a1n.<\/li>\n
      • Ph\u1ea3n \u1ee9ng v\u1edbi acid, anhydrid acid, clorid acid, ester t\u1ea1o amid; v\u1edbi propylen carbonat v\u00e0 carbonat v\u00f2ng; v\u1edbi aldehyd, ceton t\u1ea1o aldimin, ketimin.<\/li>\n
      • T\u1ea1o ph\u1ee9c v\u1edbi \u0111\u1ed3ng; \u0111\u1ed5i m\u00e0u v\u00e0 k\u1ebft t\u1ee7a khi c\u00f3 mu\u1ed1i kim lo\u1ea1i n\u1eb7ng.<\/li>\n
      • Kh\u00f4ng d\u00f9ng c\u00f9ng ch\u1ea5t g\u00e2y nitroso h\u00f3a (nguy c\u01a1 t\u1ea1o nitrosamin).<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Amoniac ph\u00e2n ethylen oxyd, thu h\u1ed7n h\u1ee3p monoethanolamin, diethanolamin v\u00e0 triethanolamin, r\u1ed3i t\u00e1ch ri\u00eang t\u1eebng ch\u1ea5t.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        DEA \u0111\u01b0\u1ee3c d\u00f9ng trong ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i v\u00e0 thu\u1ed1c ti\u00eam (\u0111\u1ebfn 1,5% trong thu\u1ed1c ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch). Li\u1ec1u t\u0129nh m\u1ea1ch l\u1edbn h\u01a1n g\u00e2y an th\u1ea7n, h\u00f4n m\u00ea, t\u1eed vong \u1edf ch\u00f3. D\u1ea1ng nguy\u00ean ch\u1ea5t ho\u1eb7c \u0111\u1eadm \u0111\u1eb7c k\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c (dung d\u1ecbch 10% ch\u1ec9 k\u00edch \u1ee9ng nh\u1eb9 tr\u00ean th\u1ecf). Ch\u01b0\u01a1ng tr\u00ecnh \u0110\u1ed9c ch\u1ea5t h\u1ecdc Qu\u1ed1c gia M\u1ef9 x\u00e1c \u0111\u1ecbnh DEA l\u00e0 ch\u1ea5t c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y ung th\u01b0 khi b\u00f4i ngo\u00e0i da tr\u00ean g\u1eb7m nh\u1ea5m (m\u1ee9c li\u00ean quan \u1edf ng\u01b0\u1eddi c\u00f2n tranh lu\u1eadn); DEA c\u0169ng g\u00e2y thi\u1ebfu cholin \u1edf gan chu\u1ed9t. H\u1ed9i \u0111\u1ed3ng CIR (M\u1ef9) cho ph\u00e9p trong m\u1ef9 ph\u1ea9m r\u1eeda tr\u00f4i, s\u1ea3n ph\u1ea9m l\u01b0u l\u00e2u tr\u00ean da gi\u1edbi h\u1ea1n ethanolamin \u2264 5%; DEA kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e9p d\u00f9ng trong m\u1ef9 ph\u1ea9m t\u1ea1i EU<\/strong>.<\/p>\n

        Thao t\u00e1c: qu\u1ea7n \u00e1o b\u1ea3o h\u1ed9, g\u0103ng tay, k\u00ednh, m\u1eb7t n\u1ea1, t\u1ed1t nh\u1ea5t trong t\u1ee7 h\u1ed1t. Gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m t\u1ea1i Anh: 13 mg\/m\u00b3 (3 ppm) trung b\u00ecnh 8 gi\u1edd. Nguy c\u01a1 ch\u00e1y nh\u1eb9.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch, dung d\u1ecbch nh\u1ecf m\u1eaft, d\u00f9ng ngo\u00e0i).<\/li>\n
        • C\u00f3 trong thu\u1ed1c \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> monoethanolamin, triethanolamin.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Diethanolamine<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Diethanolamin (DEA) \u2013 ch\u1ea5t ki\u1ec1m h\u00f3a, \u0111\u1ec7m, nh\u0169 h\u00f3a Diethanolamin (DEA, diolamin) l\u00e0 amin b\u1eadc hai c\u00f3 hai nh\u00f3m hydroxyl. Trong d\u01b0\u1ee3c ph\u1ea9m, DEA ch\u1ee7 y\u1ebfu l\u00e0m ch\u1ea5t \u0111\u1ec7m, \u0111i\u1ec1u ch\u1ec9nh pH, t\u1ea1o nh\u0169 t\u01b0\u01a1ng v\u1edbi acid b\u00e9o (t\u1ea1o x\u00e0 ph\u00f2ng amin t\u1ea1i ch\u1ed7) v\u00e0 t\u1ea1o mu\u1ed1i tan cho m\u1ed9t s\u1ed1 ho\u1ea1t ch\u1ea5t c\u00f3 t\u00ednh […]<\/p>\n","protected":false},"author":1,"featured_media":2293,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2294","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethanolamin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethanolamin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethanolamin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethanolamin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethanolamin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethanolamin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethanolamin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethanolamin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Diethanolamin (DEA) \u2013 ch\u1ea5t ki\u1ec1m h\u00f3a, \u0111\u1ec7m, nh\u0169 h\u00f3a Diethanolamin (DEA, diolamin) l\u00e0 amin b\u1eadc hai c\u00f3 hai nh\u00f3m hydroxyl. Trong d\u01b0\u1ee3c ph\u1ea9m, DEA ch\u1ee7 y\u1ebfu l\u00e0m ch\u1ea5t \u0111\u1ec7m, \u0111i\u1ec1u ch\u1ec9nh pH, t\u1ea1o nh\u0169 t\u01b0\u01a1ng v\u1edbi acid b\u00e9o (t\u1ea1o x\u00e0 ph\u00f2ng amin t\u1ea1i ch\u1ed7) v\u00e0 t\u1ea1o mu\u1ed1i tan cho m\u1ed9t s\u1ed1 ho\u1ea1t ch\u1ea5t c\u00f3 t\u00ednh…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2294"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2294\/revisions"}],"predecessor-version":[{"id":3798,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2294\/revisions\/3798"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2293"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}