{"id":2292,"date":"2026-09-27T11:15:32","date_gmt":"2026-09-27T04:15:32","guid":{"rendered":"https:\/\/cpc1.vn\/dibutyl-sebacat\/"},"modified":"2026-09-28T21:09:57","modified_gmt":"2026-09-28T14:09:57","slug":"dibutyl-sebacat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/dibutyl-sebacat\/","title":{"rendered":"Dibutyl sebacat (DBS) \u2013 ch\u1ea5t h\u00f3a d\u1ebbo m\u00e0ng bao vi\u00ean, pellet"},"content":{"rendered":"

Dibutyl sebacat (DBS) \u2013 ch\u1ea5t h\u00f3a d\u1ebbo m\u00e0ng bao vi\u00ean, pellet<\/h1>\n

Dibutyl sebacat<\/strong> (DBS) l\u00e0 ester c\u1ee7a n-butanol v\u1edbi acid sebacic (acid dicarboxylic C10). Trong b\u00e0o ch\u1ebf, DBS l\u00e0 ch\u1ea5t h\u00f3a d\u1ebbo<\/strong> cho m\u00e0ng bao vi\u00ean n\u00e9n, pellet, c\u1ed1m v\u00e0 cho vi\u00ean gi\u1ea3i ph\u00f3ng ki\u1ec3m so\u00e1t, vi nang \u2013 th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi c\u00e1c polyme ethylcellulose v\u00e0 polymethacrylat.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nButyl sebacate, dibutyl decanedioate, decanedioic acid dibutyl ester, Kodaflex DBS<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n109-43-3<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC18<\/sub>H34<\/sub>O4<\/sub> \u2013 314,47<\/td>\n<\/tr>\n
Th\u00e0nh ph\u1ea7n<\/td>\nUSP-NF: ester c\u1ee7a n-butanol v\u1edbi c\u00e1c acid dibasic no, ch\u1ee7 y\u1ebfu acid sebacic<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t h\u00f3a d\u1ebbo<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t h\u00f3a d\u1ebbo cho m\u00e0ng bao vi\u00ean n\u00e9n, h\u1ea1t (beads), c\u1ed1m \u1edf n\u1ed3ng \u0111\u1ed9 10\u201330% so v\u1edbi kh\u1ed1i l\u01b0\u1ee3ng polyme<\/strong>.<\/li>\n
  • Ch\u1ea5t h\u00f3a d\u1ebbo trong vi\u00ean gi\u1ea3i ph\u00f3ng ki\u1ec3m so\u00e1t v\u00e0 vi nang.<\/li>\n
  • H\u01b0\u01a1ng li\u1ec7u t\u1ed5ng h\u1ee3p v\u00e0 ch\u1ea5t h\u1ed7 tr\u1ee3 h\u01b0\u01a1ng trong th\u1ef1c ph\u1ea9m (v\u00ed d\u1ee5 \u0111\u1ebfn 5 ppm trong kem, \u0111\u1ed3 u\u1ed1ng kh\u00f4ng c\u1ed3n).<\/li>\n
  • L\u00e0 ester l\u00e0m m\u1ec1m \u2013 c\u1ea5p d\u00f9ng cho ch\u0103m s\u00f3c c\u00e1 nh\u00e2n \u0111\u01b0\u1ee3c d\u00f9ng trong m\u1ef9 ph\u1ea9m, s\u1ea3n ph\u1ea9m t\u00f3c, lotion, kem.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t l\u1ecfng d\u1ea1ng d\u1ea7u trong, kh\u00f4ng m\u00e0u, m\u00f9i nh\u1ea1t \u0111\u1ebfn h\u01a1i m\u00f9i butyl.<\/li>\n
    • Nhi\u1ec7t \u0111\u1ed9 s\u00f4i 344\u2013349 \u00b0C; \u0111i\u1ec3m \u0111\u00f4ng \u0111\u1eb7c kho\u1ea3ng \u221210 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 193 \u00b0C.<\/li>\n
    • T\u1ef7 tr\u1ecdng 0,937 (20 \u00b0C); chi\u1ebft su\u1ea5t nD<\/sub>25<\/sup> 1,4401; ch\u1ec9 s\u1ed1 acid 0,02.<\/li>\n
    • Tan trong ethanol 95%, isopropanol, d\u1ea7u kho\u00e1ng; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc \u2013 th\u00edch h\u1ee3p cho h\u1ec7 bao ph\u00e2n t\u00e1n n\u01b0\u1edbc c\u1ea7n ch\u1ea5t h\u00f3a d\u1ebbo k\u1ef5 n\u01b0\u1edbc.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n, kh\u00f4ng ph\u1ea3n \u1ee9ng v\u1edbi n\u01b0\u1edbc, kh\u00f4ng x\u1ea3y ra tr\u00f9ng h\u1ee3p nguy hi\u1ec3m. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 ki\u1ec1m m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ester h\u00f3a n-butanol v\u00e0 acid sebacic c\u00f3 x\u00fac t\u00e1c th\u00edch h\u1ee3p, ho\u1eb7c ch\u01b0ng c\u1ea5t acid sebacic v\u1edbi n-butanol c\u00f3 acid \u0111\u1eadm \u0111\u1eb7c.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      D\u00f9ng trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 thu\u1ed1c u\u1ed1ng; \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; sau khi u\u1ed1ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a nh\u01b0 ch\u1ea5t b\u00e9o. D\u00ednh m\u1eaft tr\u1ef1c ti\u1ebfp ho\u1eb7c ti\u1ebfp x\u00fac da k\u00e9o d\u00e0i c\u00f3 th\u1ec3 k\u00edch \u1ee9ng r\u1ea5t nh\u1eb9. Nghi\u00ean c\u1ee9u \u0111\u1ed9c t\u00ednh c\u1ea5p v\u00e0 d\u00e0i h\u1ea1n tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng th\u1ea5y t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i nghi\u00eam tr\u1ecdng. Lu\u00f4n \u0111eo k\u00ednh; khi gia nhi\u1ec7t c\u1ea7n th\u00f4ng gi\u00f3 t\u1ed1t v\u00e0 d\u00f9ng m\u1eb7t n\u1ea1.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • C\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean nang, c\u1ed1m, vi\u00ean bao phim, vi\u00ean gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i, vi\u00ean n\u00e9n u\u1ed1ng).<\/li>\n
      • C\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> triethyl citrat, acetyltributyl citrat, diethyl phthalat, triacetin.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Dibutyl Sebacate<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Dibutyl sebacat (DBS) \u2013 ch\u1ea5t h\u00f3a d\u1ebbo m\u00e0ng bao vi\u00ean, pellet Dibutyl sebacat (DBS) l\u00e0 ester c\u1ee7a n-butanol v\u1edbi acid sebacic (acid dicarboxylic C10). Trong b\u00e0o ch\u1ebf, DBS l\u00e0 ch\u1ea5t h\u00f3a d\u1ebbo cho m\u00e0ng bao vi\u00ean n\u00e9n, pellet, c\u1ed1m v\u00e0 cho vi\u00ean gi\u1ea3i ph\u00f3ng ki\u1ec3m so\u00e1t, vi nang \u2013 th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi c\u00e1c polyme […]<\/p>","protected":false},"author":1,"featured_media":2291,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2292","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dibutyl-sebacat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dibutyl-sebacat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dibutyl-sebacat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dibutyl-sebacat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dibutyl-sebacat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dibutyl-sebacat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dibutyl-sebacat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dibutyl-sebacat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Dibutyl sebacat (DBS) \u2013 ch\u1ea5t h\u00f3a d\u1ebbo m\u00e0ng bao vi\u00ean, pellet Dibutyl sebacat (DBS) l\u00e0 ester c\u1ee7a n-butanol v\u1edbi acid sebacic (acid dicarboxylic C10). Trong b\u00e0o ch\u1ebf, DBS l\u00e0 ch\u1ea5t h\u00f3a d\u1ebbo cho m\u00e0ng bao vi\u00ean n\u00e9n, pellet, c\u1ed1m v\u00e0 cho vi\u00ean gi\u1ea3i ph\u00f3ng ki\u1ec3m so\u00e1t, vi nang \u2013 th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi c\u00e1c polyme…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2292"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2292\/revisions"}],"predecessor-version":[{"id":3205,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2292\/revisions\/3205"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2291"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}