{"id":2278,"date":"2026-09-27T11:11:31","date_gmt":"2026-09-27T04:11:31","guid":{"rendered":"https:\/\/cpc1.vn\/cyclodextrin\/"},"modified":"2026-09-28T21:07:47","modified_gmt":"2026-09-28T14:07:47","slug":"cyclodextrin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/cyclodextrin\/","title":{"rendered":"Cyclodextrin (\u03b1, \u03b2, \u03b3, HP-\u03b2-CD) \u2013 t\u00e1 d\u01b0\u1ee3c t\u1ea1o ph\u1ee9c, t\u0103ng \u0111\u1ed9 tan"},"content":{"rendered":"

Cyclodextrin (\u03b1, \u03b2, \u03b3, HP-\u03b2-CD) \u2013 t\u00e1 d\u01b0\u1ee3c t\u1ea1o ph\u1ee9c, t\u0103ng \u0111\u1ed9 tan<\/h1>\n

Cyclodextrin<\/strong> l\u00e0 c\u00e1c oligosaccharid v\u00f2ng thu t\u1eeb tinh b\u1ed9t, g\u1ed3m \u00edt nh\u1ea5t 6 \u0111\u01a1n v\u1ecb D-glucopyranose n\u1ed1i nhau b\u1eb1ng li\u00ean k\u1ebft \u03b1(1\u21924). Ph\u00e2n t\u1eed c\u00f3 h\u00ecnh “x\u00f4” hay “n\u00f3n c\u1ee5t” v\u1edbi khoang gi\u1eefa k\u1ef5 n\u01b0\u1edbc v\u00e0 m\u1eb7t ngo\u00e0i \u01b0a n\u01b0\u1edbc<\/strong> \u2013 cho ph\u00e9p “\u00f4m” ph\u00e2n t\u1eed ho\u1ea1t ch\u1ea5t v\u00e0o khoang, t\u1ea1o ph\u1ee9c l\u1ed3ng<\/strong> (inclusion complex).<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
<\/th>\n\u03b1-Cyclodextrin<\/th>\n\u03b2-Cyclodextrin<\/th>\n\u03b3-Cyclodextrin<\/th>\n<\/tr>\n<\/thead>\n
S\u1ed1 \u0111\u01a1n v\u1ecb glucose<\/td>\n6<\/td>\n7<\/td>\n8<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c<\/td>\nC36<\/sub>H60<\/sub>O30<\/sub><\/td>\nC42<\/sub>H70<\/sub>O35<\/sub><\/td>\nC48<\/sub>H80<\/sub>O40<\/sub><\/td>\n<\/tr>\n
KLPT<\/td>\n972<\/td>\n1135<\/td>\n1297<\/td>\n<\/tr>\n
CAS<\/td>\n10016-20-3<\/td>\n7585-39-9<\/td>\n17465-86-0<\/td>\n<\/tr>\n
\u0110\u01b0\u1eddng k\u00ednh khoang (\u00c5)<\/td>\n4,7\u20135,3<\/td>\n6,0\u20136,5<\/td>\n7,5\u20138,3<\/td>\n<\/tr>\n
\u0110\u1ed9 tan trong n\u01b0\u1edbc (20 \u00b0C)<\/td>\n1\/7<\/td>\n1\/50 (k\u00e9m nh\u1ea5t)<\/td>\n1\/4,4<\/td>\n<\/tr>\n
\u0110\u1ed9 \u1ea9m<\/td>\nkho\u1ea3ng 10%<\/td>\n13\u201315%<\/td>\n8\u201318%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

T\u00ean th\u01b0\u01a1ng m\u1ea1i: Cavamax W6\/W7\/W8 Pharma, Kleptose (\u03b2-CD)\u2026 Nh\u00f3m ch\u1ee9c n\u0103ng: ch\u1ea5t h\u00f2a tan, ch\u1ea5t \u1ed5n \u0111\u1ecbnh.<\/p>\n

\u1ee8ng d\u1ee5ng trong b\u00e0o ch\u1ebf<\/h2>\n
    \n
  • T\u0103ng \u0111\u1ed9 tan, t\u1ed1c \u0111\u1ed9 h\u00f2a tan v\u00e0 sinh kh\u1ea3 d\u1ee5ng<\/strong>; c\u1ea3i thi\u1ec7n \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh h\u00f3a h\u1ecdc v\u00e0 v\u1eadt l\u00fd c\u1ee7a ho\u1ea1t ch\u1ea5t.<\/li>\n
  • Che v\u1ecb kh\u00f3 ch\u1ecbu; chuy\u1ec3n ch\u1ea5t l\u1ecfng th\u00e0nh d\u1ea1ng r\u1eafn.<\/li>\n
  • \u03b2-cyclodextrin<\/strong>: d\u00f9ng nhi\u1ec1u nh\u1ea5t (r\u1ebb, nhi\u1ec1u ngu\u1ed3n, t\u1ea1o ph\u1ee9c v\u1edbi nhi\u1ec1u ho\u1ea1t ch\u1ea5t) d\u00f9 tan k\u00e9m nh\u1ea5t; d\u00f9ng cho vi\u00ean n\u00e9n, vi\u00ean nang \u0111\u01b0\u1eddng u\u1ed1ng. Tr\u01a1n ch\u1ea3y k\u00e9m \u2013 d\u1eadp th\u1eb3ng c\u1ea7n t\u00e1 d\u01b0\u1ee3c tr\u01a1n (v\u00ed d\u1ee5 magnesi stearat 0,1%). Kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam<\/strong> v\u00ec \u0111\u1ed9c th\u1eadn.<\/li>\n
  • \u03b1-cyclodextrin<\/strong>: khoang nh\u1ecf nh\u1ea5t, ch\u1ec9 t\u1ea1o ph\u1ee9c v\u1edbi \u00edt ph\u00e2n t\u1eed nh\u1ecf; d\u00f9ng ch\u1ee7 y\u1ebfu trong thu\u1ed1c ti\u00eam.<\/li>\n
  • \u03b3-cyclodextrin<\/strong>: khoang l\u1edbn nh\u1ea5t, t\u1ea1o ph\u1ee9c v\u1edbi ph\u00e2n t\u1eed l\u1edbn; \u0111\u1ed9c t\u00ednh th\u1ea5p, tan t\u1ed1t.<\/li>\n
  • D\u1eabn ch\u1ea5t<\/strong> (2-hydroxypropyl-\u03b2-CD, dimethyl-\u03b2-CD, hydroxyethyl-\u03b2-CD\u2026): tan t\u1ed1t h\u01a1n nhi\u1ec1u, kh\u00f4ng \u0111\u1ed9c th\u1eadn \u2013 ng\u00e0y c\u00e0ng quan tr\u1ecdng cho thu\u1ed1c ti\u00eam v\u00e0 nh\u1ecf m\u1eaft.<\/li>\n
  • Thu\u1ed1c ti\u00eam: thay dung m\u00f4i kh\u00f4ng n\u01b0\u1edbc \u0111\u1ec3 c\u00f3 ch\u1ebf ph\u1ea9m b\u1ec1n v\u00e0 tan. Thu\u1ed1c nh\u1ecf m\u1eaft: t\u1ea1o ph\u1ee9c tan v\u1edbi ho\u1ea1t ch\u1ea5t th\u00e2n d\u1ea7u (nh\u01b0 corticosteroid), t\u0103ng h\u1ea5p thu v\u00e0o m\u1eaft, t\u0103ng \u0111\u1ed9 b\u1ec1n, gi\u1ea3m k\u00edch \u1ee9ng.<\/li>\n
  • Dung d\u1ecbch, thu\u1ed1c \u0111\u1eb7t, m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh m\u1ecbn, tr\u1eafng, g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i, h\u01a1i ng\u1ecdt; m\u1ed9t s\u1ed1 d\u1eabn ch\u1ea5t \u1edf d\u1ea1ng b\u1ed9t v\u00f4 \u0111\u1ecbnh h\u00ecnh. Kh\u00f4ng h\u00fat \u1ea9m.<\/li>\n
    • N\u00f3ng ch\u1ea3y: \u03b1 250\u2013260 \u00b0C; \u03b2 255\u2013265 \u00b0C; \u03b3 240\u2013245 \u00b0C.<\/li>\n
    • T\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn kho\u1ea3ng 0,52\u20130,57 g\/cm\u00b3; ch\u1ec9 s\u1ed1 n\u00e9n \u03b2-CD 21\u201344%.<\/li>\n
    • \u03b2-CD tan 1\/20 trong n\u01b0\u1edbc \u1edf 50 \u00b0C, 1\/200 trong propylen glycol; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong aceton, ethanol, methylen clorid.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n \u1edf tr\u1ea1ng th\u00e1i r\u1eafn n\u1ebfu tr\u00e1nh \u0111\u1ed9 \u1ea9m cao. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      Hydroxypropyl-\u03b2-cyclodextrin c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ho\u1ea1t t\u00ednh c\u1ee7a m\u1ed9t s\u1ed1 ch\u1ea5t b\u1ea3o qu\u1ea3n trong dung d\u1ecbch n\u01b0\u1edbc (do t\u1ea1o ph\u1ee9c v\u1edbi ch\u1ea5t b\u1ea3o qu\u1ea3n).<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Th\u1ee7y ph\u00e2n tinh b\u1ed9t b\u1eb1ng enzym cyclodextrin glucosyltransferase t\u1eeb vi khu\u1ea9n. V\u1edbi \u03b2-CD, dung m\u00f4i h\u1eefu c\u01a1 \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111\u1ecbnh h\u01b0\u1edbng ph\u1ea3n \u1ee9ng v\u00e0 \u1ee9c ch\u1ebf vi sinh; ph\u1ee9c kh\u00f4ng tan \u03b2-CD\u2013dung m\u00f4i \u0111\u01b0\u1ee3c t\u00e1ch kh\u1ecfi tinh b\u1ed9t kh\u00f4ng v\u00f2ng, lo\u1ea1i dung m\u00f4i d\u01b0\u1edbi ch\u00e2n kh\u00f4ng (c\u00f2n d\u01b0\u1edbi 1 ppm), x\u1eed l\u00fd than ho\u1ea1t v\u00e0 k\u1ebft tinh l\u1ea1i trong n\u01b0\u1edbc. Hydroxyethyl- v\u00e0 hydroxypropyl-\u03b2-CD \u0111i\u1ec1u ch\u1ebf b\u1eb1ng ph\u1ea3n \u1ee9ng \u03b2-CD v\u1edbi ethylen oxyd ho\u1eb7c propylen oxyd.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      Cyclodextrin \u0111\u01b0\u1ee3c xem l\u00e0 g\u1ea7n nh\u01b0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; \u0111\u01b0\u1eddng u\u1ed1ng \u0111\u01b0\u1ee3c vi khu\u1ea9n \u0111\u1ea1i tr\u00e0ng chuy\u1ec3n h\u00f3a th\u00e0nh maltodextrin, maltose, glucose r\u1ed3i CO2<\/sub> v\u00e0 n\u01b0\u1edbc; \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn trong th\u1ef1c ph\u1ea9m v\u00e0 thu\u1ed1c u\u1ed1ng \u1edf nhi\u1ec1u n\u01b0\u1edbc. Ri\u00eang \u03b2-CD ti\u00eam<\/strong> kh\u00f4ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a, t\u00edch t\u1ee5 \u1edf th\u1eadn d\u01b0\u1edbi d\u1ea1ng ph\u1ee9c cholesterol kh\u00f4ng tan g\u00e2y \u0111\u1ed9c th\u1eadn n\u1eb7ng; 2-hydroxypropyl-\u03b2-CD \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ed9c t\u00ednh r\u1ed9ng v\u00e0 \u0111\u01b0\u1ee3c xem l\u00e0 an to\u00e0n cho thu\u1ed1c ti\u00eam. Cyclodextrin kh\u00f4ng k\u00edch \u1ee9ng da, m\u1eaft, h\u00f4 h\u1ea5p; kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng g\u00e2y \u0111\u1ed9t bi\u1ebfn, qu\u00e1i thai. B\u1ed9t h\u1eefu c\u01a1 m\u1ecbn \u2013 thao t\u00e1c n\u01a1i th\u00f4ng gi\u00f3, h\u1ea1n ch\u1ebf b\u1ee5i (nguy c\u01a1 n\u1ed5 b\u1ee5i).<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • \u03b2-cyclodextrin c\u00f3 trong FDA Inactive Ingredients Guide (ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch v\u00e0 d\u1ea1ng ti\u00eam kh\u00e1c \u2013 theo th\u00f4ng tin n\u0103m 2006).<\/li>\n
      • C\u00f3 trong thu\u1ed1c u\u1ed1ng v\u00e0 tr\u1ef1c tr\u00e0ng \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i ch\u00e2u \u00c2u, Nh\u1eadt B\u1ea3n, M\u1ef9; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. (\u03b1-, \u03b2-cyclodextrin, hydroxypropylbetadex) v\u00e0 USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> dimethyl-\u03b2-CD, 2-hydroxyethyl-\u03b2-CD, 2- v\u00e0 3-hydroxypropyl-\u03b2-CD, trimethyl-\u03b2-CD, sulfobutylether-\u03b2-CD.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Cyclodextrins<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Cyclodextrin (\u03b1, \u03b2, \u03b3, HP-\u03b2-CD) \u2013 t\u00e1 d\u01b0\u1ee3c t\u1ea1o ph\u1ee9c, t\u0103ng \u0111\u1ed9 tan Cyclodextrin l\u00e0 c\u00e1c oligosaccharid v\u00f2ng thu t\u1eeb tinh b\u1ed9t, g\u1ed3m \u00edt nh\u1ea5t 6 \u0111\u01a1n v\u1ecb D-glucopyranose n\u1ed1i nhau b\u1eb1ng li\u00ean k\u1ebft \u03b1(1\u21924). Ph\u00e2n t\u1eed c\u00f3 h\u00ecnh “x\u00f4” hay “n\u00f3n c\u1ee5t” v\u1edbi khoang gi\u1eefa k\u1ef5 n\u01b0\u1edbc v\u00e0 m\u1eb7t ngo\u00e0i \u01b0a n\u01b0\u1edbc \u2013 cho […]<\/p>","protected":false},"author":1,"featured_media":2277,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2278","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cyclodextrin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cyclodextrin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cyclodextrin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cyclodextrin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cyclodextrin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cyclodextrin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cyclodextrin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cyclodextrin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Cyclodextrin (\u03b1, \u03b2, \u03b3, HP-\u03b2-CD) \u2013 t\u00e1 d\u01b0\u1ee3c t\u1ea1o ph\u1ee9c, t\u0103ng \u0111\u1ed9 tan Cyclodextrin l\u00e0 c\u00e1c oligosaccharid v\u00f2ng thu t\u1eeb tinh b\u1ed9t, g\u1ed3m \u00edt nh\u1ea5t 6 \u0111\u01a1n v\u1ecb D-glucopyranose n\u1ed1i nhau b\u1eb1ng li\u00ean k\u1ebft \u03b1(1\u21924). Ph\u00e2n t\u1eed c\u00f3 h\u00ecnh “x\u00f4” hay “n\u00f3n c\u1ee5t” v\u1edbi khoang gi\u1eefa k\u1ef5 n\u01b0\u1edbc v\u00e0 m\u1eb7t ngo\u00e0i \u01b0a n\u01b0\u1edbc \u2013 cho…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2278"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2278\/revisions"}],"predecessor-version":[{"id":3182,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2278\/revisions\/3182"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2277"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2278"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2278"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}