{"id":2274,"date":"2026-09-27T11:10:36","date_gmt":"2026-09-27T04:10:36","guid":{"rendered":"https:\/\/cpc1.vn\/croscarmellose-natri\/"},"modified":"2026-09-28T21:07:37","modified_gmt":"2026-09-28T14:07:37","slug":"croscarmellose-natri","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/croscarmellose-natri\/","title":{"rendered":"Croscarmellose natri (Ac-Di-Sol) \u2013 t\u00e1 d\u01b0\u1ee3c si\u00eau r\u00e3 cho vi\u00ean n\u00e9n, nang"},"content":{"rendered":"

Croscarmellose natri (Ac-Di-Sol) \u2013 t\u00e1 d\u01b0\u1ee3c si\u00eau r\u00e3 cho vi\u00ean n\u00e9n, nang<\/h1>\n

Croscarmellose natri<\/strong> (Ac-Di-Sol, Primellose, Vivasol) l\u00e0 natri carboxymethylcellulose \u0111\u01b0\u1ee3c li\u00ean k\u1ebft ch\u00e9o<\/strong>, n\u00ean kh\u00f4ng tan m\u00e0 tr\u01b0\u01a1ng n\u1edf r\u1ea5t nhanh khi g\u1eb7p n\u01b0\u1edbc. \u0110\u00e2y l\u00e0 m\u1ed9t trong ba “si\u00eau r\u00e3” (superdisintegrant) ph\u1ed5 bi\u1ebfn nh\u1ea5t, c\u00f9ng v\u1edbi crospovidon v\u00e0 natri starch glycolat.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nCrosslinked carboxymethylcellulose sodium, modified cellulose gum; Ac-Di-Sol, Explocel, Nymcel ZSX, Pharmacel XL, Primellose, Solutab, Vivasol<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n74811-65-7<\/td>\n<\/tr>\n
C\u1ea5u t\u1ea1o<\/td>\nPolyme li\u00ean k\u1ebft ch\u00e9o c\u1ee7a natri carboxymethylcellulose; m\u1ee9c \u0111\u1ed9 th\u1ebf (DS) \u0111i\u1ec3n h\u00ecnh 0,7<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nT\u00e1 d\u01b0\u1ee3c r\u00e3 vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n\n\n\n\n\n\n
Vai tr\u00f2<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
T\u00e1 d\u01b0\u1ee3c r\u00e3 vi\u00ean n\u00e9n<\/td>\n0,5\u20135,0<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c r\u00e3 vi\u00ean nang<\/td>\n10\u201325<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • D\u00f9ng cho vi\u00ean nang, vi\u00ean n\u00e9n v\u00e0 c\u1ed1m, qua d\u1eadp th\u1eb3ng ho\u1eb7c x\u00e1t h\u1ea1t \u01b0\u1edbt.<\/li>\n
  • Th\u01b0\u1eddng d\u00f9ng kho\u1ea3ng 2%<\/strong> cho vi\u00ean d\u1eadp th\u1eb3ng v\u00e0 3%<\/strong> cho vi\u00ean x\u00e1t h\u1ea1t \u01b0\u1edbt; t\u1ed1i \u0111a kho\u1ea3ng 5%.<\/li>\n
  • Khi x\u00e1t h\u1ea1t \u01b0\u1edbt, n\u00ean chia croscarmellose v\u00e0o c\u1ea3 trong h\u1ea1t v\u00e0 ngo\u00e0i h\u1ea1t<\/strong> \u0111\u1ec3 t\u1eadn d\u1ee5ng t\u1ed1i \u0111a kh\u1ea3 n\u0103ng h\u00fat n\u01b0\u1edbc mao qu\u1ea3n v\u00e0 tr\u01b0\u01a1ng n\u1edf.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng ho\u1eb7c tr\u1eafng x\u00e1m, kh\u00f4ng m\u00f9i.<\/li>\n
    • pH h\u1ec7 ph\u00e2n t\u00e1n n\u01b0\u1edbc 5,0\u20137,0.<\/li>\n
    • Kh\u00f4ng tan trong n\u01b0\u1edbc nh\u01b0ng tr\u01b0\u01a1ng n\u1edf nhanh 4\u20138 l\u1ea7n th\u1ec3 t\u00edch<\/strong>; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong aceton, ethanol, toluen.<\/li>\n
    • Ac-Di-Sol: t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,529 g\/cm\u00b3, t\u1ef7 tr\u1ecdng g\u00f5 0,819 g\/cm\u00b3, t\u1ef7 tr\u1ecdng th\u1ef1c 1,543 g\/cm\u00b3; kh\u00f4ng qu\u00e1 2% c\u00f2n tr\u00ean r\u00e2y 73,7 \u00b5m v\u00e0 10% tr\u00ean r\u00e2y 44,5 \u00b5m.<\/li>\n
    • Di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t ri\u00eang 0,81\u20130,83 m\u00b2\/g.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n nh\u01b0ng h\u00fat \u1ea9m. Vi\u00ean m\u1eabu d\u1eadp th\u1eb3ng v\u1edbi croscarmellose natri kh\u00f4ng thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 \u0111\u1ed9 h\u00f2a tan sau 14 th\u00e1ng \u1edf 30 \u00b0C. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • Hi\u1ec7u qu\u1ea3 r\u00e3 c\u00f3 th\u1ec3 gi\u1ea3m nh\u1eb9 trong c\u00f4ng th\u1ee9c ch\u1ee9a t\u00e1 d\u01b0\u1ee3c h\u00fat \u1ea9m nh\u01b0 sorbitol.<\/li>\n
      • Kh\u00f4ng t\u01b0\u01a1ng h\u1ee3p v\u1edbi acid m\u1ea1nh v\u00e0 mu\u1ed1i tan c\u1ee7a s\u1eaft, m\u1ed9t s\u1ed1 kim lo\u1ea1i (nh\u00f4m, th\u1ee7y ng\u00e2n, k\u1ebdm).<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Cellulose (b\u1ed9t g\u1ed7, s\u1ee3i b\u00f4ng) ng\u00e2m NaOH t\u1ea1o cellulose ki\u1ec1m, ph\u1ea3n \u1ee9ng v\u1edbi natri monocloroacetat t\u1ea1o natri CMC. Sau khi NaOH h\u1ebft, natri monocloroacetat d\u01b0 th\u1ee7y ph\u00e2n ch\u1eadm th\u00e0nh acid glycolic \u2013 chuy\u1ec3n m\u1ed9t s\u1ed1 nh\u00f3m carboxymethyl sang d\u1ea1ng acid t\u1ef1 do v\u00e0 x\u00fac t\u00e1c t\u1ea1o li\u00ean k\u1ebft ch\u00e9o. S\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c chi\u1ebft b\u1eb1ng c\u1ed3n\u2013n\u01b0\u1edbc \u0111\u1ec3 lo\u1ea1i NaCl, natri glycolat, \u0111\u1ea1t \u0111\u1ed9 tinh khi\u1ebft tr\u00ean 99,5%; c\u00f3 th\u1ec3 nghi\u1ec1n \u0111\u1ec3 c\u1eaft ng\u1eafn s\u1ee3i, c\u1ea3i thi\u1ec7n tr\u01a1n ch\u1ea3y.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        D\u00f9ng ch\u1ee7 y\u1ebfu trong thu\u1ed1c u\u1ed1ng, \u0111\u01b0\u1ee3c xem l\u00e0 g\u1ea7n nh\u01b0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; l\u01b0\u1ee3ng r\u1ea5t l\u1edbn c\u00f3 th\u1ec3 nhu\u1eadn tr\u00e0ng (kh\u00f3 x\u1ea3y ra \u1edf l\u01b0\u1ee3ng d\u00f9ng trong vi\u00ean). \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn trong th\u1ef1c ph\u1ea9m b\u1ed5 sung t\u1ea1i Anh. WHO kh\u00f4ng quy \u0111\u1ecbnh ADI cho natri CMC l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft \u2013 \u0111eo k\u00ednh.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean nang, c\u1ed1m, vi\u00ean ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i, vi\u00ean n\u00e9n).<\/li>\n
        • C\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong JP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> carmellose calci, natri carboxymethylcellulose, crospovidon, natri starch glycolat.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Croscarmellose Sodium<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Croscarmellose natri (Ac-Di-Sol) \u2013 t\u00e1 d\u01b0\u1ee3c si\u00eau r\u00e3 cho vi\u00ean n\u00e9n, nang Croscarmellose natri (Ac-Di-Sol, Primellose, Vivasol) l\u00e0 natri carboxymethylcellulose \u0111\u01b0\u1ee3c li\u00ean k\u1ebft ch\u00e9o, n\u00ean kh\u00f4ng tan m\u00e0 tr\u01b0\u01a1ng n\u1edf r\u1ea5t nhanh khi g\u1eb7p n\u01b0\u1edbc. \u0110\u00e2y l\u00e0 m\u1ed9t trong ba “si\u00eau r\u00e3” (superdisintegrant) ph\u1ed5 bi\u1ebfn nh\u1ea5t, c\u00f9ng v\u1edbi crospovidon v\u00e0 natri starch glycolat. Th\u00f4ng tin […]<\/p>","protected":false},"author":1,"featured_media":2273,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2274","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/croscarmellose-natri.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/croscarmellose-natri-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/croscarmellose-natri-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/croscarmellose-natri-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/croscarmellose-natri-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/croscarmellose-natri.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/croscarmellose-natri.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/croscarmellose-natri-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Croscarmellose natri (Ac-Di-Sol) \u2013 t\u00e1 d\u01b0\u1ee3c si\u00eau r\u00e3 cho vi\u00ean n\u00e9n, nang Croscarmellose natri (Ac-Di-Sol, Primellose, Vivasol) l\u00e0 natri carboxymethylcellulose \u0111\u01b0\u1ee3c li\u00ean k\u1ebft ch\u00e9o, n\u00ean kh\u00f4ng tan m\u00e0 tr\u01b0\u01a1ng n\u1edf r\u1ea5t nhanh khi g\u1eb7p n\u01b0\u1edbc. \u0110\u00e2y l\u00e0 m\u1ed9t trong ba “si\u00eau r\u00e3” (superdisintegrant) ph\u1ed5 bi\u1ebfn nh\u1ea5t, c\u00f9ng v\u1edbi crospovidon v\u00e0 natri starch glycolat. Th\u00f4ng tin…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2274"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2274\/revisions"}],"predecessor-version":[{"id":3180,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2274\/revisions\/3180"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2273"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}