{"id":2270,"date":"2026-09-27T11:09:30","date_gmt":"2026-09-27T04:09:30","guid":{"rendered":"https:\/\/cpc1.vn\/cresol\/"},"modified":"2026-09-28T21:07:31","modified_gmt":"2026-09-28T14:07:31","slug":"cresol","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/cresol\/","title":{"rendered":"Cresol (m-cresol) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho thu\u1ed1c ti\u00eam"},"content":{"rendered":"

Cresol (m-cresol) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho thu\u1ed1c ti\u00eam<\/h1>\n

Cresol<\/strong> l\u00e0 h\u1ed7n h\u1ee3p c\u00e1c \u0111\u1ed3ng ph\u00e2n methylphenol (ch\u1ee7 y\u1ebfu m-cresol) v\u00e0 c\u00e1c phenol kh\u00e1c, l\u1ea5y t\u1eeb nh\u1ef1a than \u0111\u00e1 ho\u1eb7c d\u1ea7u m\u1ecf. Trong b\u00e0o ch\u1ebf, cresol (v\u00e0 m-cresol tinh khi\u1ebft) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n cho thu\u1ed1c ti\u00eam<\/strong> \u2013 quen thu\u1ed9c trong c\u00e1c ch\u1ebf ph\u1ea9m insulin v\u00e0 peptid.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nCresylic acid, cresylol, hydroxytoluene, tricresol<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n1319-77-3 (cresol); 108-39-4 (m-cresol)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC7<\/sub>H8<\/sub>O \u2013 108,14<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t s\u00e1t khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t b\u1ea3o qu\u1ea3n cho thu\u1ed1c ti\u00eam b\u1eafp, trong da, d\u01b0\u1edbi da \u1edf n\u1ed3ng \u0111\u1ed9 0,15\u20130,3%<\/strong>.<\/li>\n
  • Ch\u1ea5t b\u1ea3o qu\u1ea3n trong m\u1ed9t s\u1ed1 ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i; ch\u1ea5t s\u00e1t khu\u1ea9n.<\/li>\n
  • Kh\u00f4ng ph\u00f9 h\u1ee3p<\/strong> l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n cho ch\u1ebf ph\u1ea9m c\u1ea7n \u0111\u00f4ng kh\u00f4.<\/li>\n<\/ul>\n

    Ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n<\/h2>\n
      \n
    • T\u01b0\u01a1ng t\u1ef1 phenol nh\u01b0ng m\u1ea1nh h\u01a1n m\u1ed9t ch\u00fat; t\u00e1c d\u1ee5ng trung b\u00ecnh tr\u00ean vi khu\u1ea9n Gram d\u01b0\u01a1ng, y\u1ebfu h\u01a1n tr\u00ean Gram \u00e2m, n\u1ea5m men, n\u1ea5m m\u1ed1c; kh\u00f4ng \u0111\u00e1ng k\u1ec3 tr\u00ean b\u00e0o t\u1eed.<\/li>\n
    • C\u00f3 t\u00e1c d\u1ee5ng d\u01b0\u1edbi pH 9, t\u1ed1i \u01b0u trong m\u00f4i tr\u01b0\u1eddng acid; c\u00f3 hi\u1ec7p \u0111\u1ed3ng v\u1edbi c\u00e1c ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c.<\/li>\n
    • Dung d\u1ecbch 0,3\u20130,6% d\u00f9ng s\u00e1t khu\u1ea9n ti\u00eau di\u1ec7t ph\u1ea7n l\u1edbn m\u1ea7m b\u1ec7nh th\u00f4ng th\u01b0\u1eddng trong kho\u1ea3ng 10 ph\u00fat.<\/li>\n<\/ul>\n

      M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
        \n
      • Ch\u1ea5t l\u1ecfng kh\u00f4ng m\u00e0u, v\u00e0ng nh\u1ea1t, v\u00e0ng n\u00e2u nh\u1ea1t ho\u1eb7c h\u1ed3ng; m\u00f9i gi\u1ed1ng phenol nh\u01b0ng n\u1eb7ng m\u00f9i h\u1eafc \u00edn h\u01a1n; dung d\u1ecbch n\u01b0\u1edbc v\u1ecb h\u0103ng.<\/li>\n
      • T\u1ef7 tr\u1ecdng 1,029\u20131,044; kho\u1ea3ng ch\u01b0ng c\u1ea5t 195\u2013205 \u00b0C. m-Cresol: s\u00f4i 202 \u00b0C, n\u00f3ng ch\u1ea3y 11\u201312 \u00b0C, \u0111i\u1ec3m ch\u1edbp ch\u00e1y 86 \u00b0C.<\/li>\n
      • Tan 1\/50 trong n\u01b0\u1edbc; tr\u1ed9n l\u1eabn v\u1edbi glycerin, benzen; d\u1ec5 tan trong ethanol, cloroform, ether, d\u1ea7u b\u00e9o, tinh d\u1ea7u v\u00e0 dung d\u1ecbch hydroxyd ki\u1ec1m.<\/li>\n<\/ul>\n

        \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

        Cresol v\u00e0 dung d\u1ecbch n\u01b0\u1edbc s\u1eabm m\u00e0u theo th\u1eddi gian v\u00e0 khi ti\u1ebfp x\u00fac kh\u00f4ng kh\u00ed, \u00e1nh s\u00e1ng. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        T\u01b0\u01a1ng k\u1ef5 v\u1edbi clorpromazin. Ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion h\u00f3a l\u00e0m gi\u1ea3m ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        L\u1ea5y t\u1eeb nh\u1ef1a than \u0111\u00e1, ho\u1eb7c t\u1ed5ng h\u1ee3p b\u1eb1ng sulfon h\u00f3a hay oxy h\u00f3a toluen.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        Ph\u1ea7n l\u1edbn ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i li\u00ean quan \u0111\u1ebfn nguy\u00ean li\u1ec7u \u0111\u1eadm \u0111\u1eb7c ho\u1eb7c dung d\u1ecbch s\u00e1t khu\u1ea9n ch\u1ee9a \u0111\u1ebfn 50% cresol, kh\u00f4ng ph\u1ea3i \u1edf m\u1ee9c d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n. Cresol \u00edt \u0103n da v\u00e0 \u00edt \u0111\u1ed9c h\u01a1n phenol nh\u01b0ng v\u1eabn \u0111\u1ee7 \u0103n da \u0111\u1ec3 kh\u00f4ng d\u00f9ng s\u00e1t khu\u1ea9n da v\u00e0 v\u1ebft th\u01b0\u01a1ng; chuy\u1ec3n h\u00f3a v\u00e0 th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu d\u01b0\u1edbi d\u1ea1ng glucuronid. Cresol k\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c \u2013 d\u00f9ng k\u00ednh, g\u0103ng tay, m\u1eb7t n\u1ea1. Gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m t\u1ea1i Anh: 22 mg\/m\u00b3 (5 ppm) trung b\u00ecnh 8 gi\u1edd.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Guide (ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch, trong da, d\u01b0\u1edbi da).<\/li>\n
        • C\u00f3 trong thu\u1ed1c ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP v\u00e0 USP-NF (m-cresol c\u00f3 chuy\u00ean lu\u1eadn ri\u00eang trong Ph.Eur.).<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> clorocresol, m-cresol, o-cresol, p-cresol, phenol.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Cresol<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Cresol (m-cresol) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho thu\u1ed1c ti\u00eam Cresol l\u00e0 h\u1ed7n h\u1ee3p c\u00e1c \u0111\u1ed3ng ph\u00e2n methylphenol (ch\u1ee7 y\u1ebfu m-cresol) v\u00e0 c\u00e1c phenol kh\u00e1c, l\u1ea5y t\u1eeb nh\u1ef1a than \u0111\u00e1 ho\u1eb7c d\u1ea7u m\u1ecf. Trong b\u00e0o ch\u1ebf, cresol (v\u00e0 m-cresol tinh khi\u1ebft) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n cho thu\u1ed1c ti\u00eam \u2013 quen thu\u1ed9c trong c\u00e1c ch\u1ebf […]<\/p>","protected":false},"author":1,"featured_media":2269,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2270","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cresol.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cresol-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cresol-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cresol-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cresol-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cresol.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cresol.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cresol-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Cresol (m-cresol) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho thu\u1ed1c ti\u00eam Cresol l\u00e0 h\u1ed7n h\u1ee3p c\u00e1c \u0111\u1ed3ng ph\u00e2n methylphenol (ch\u1ee7 y\u1ebfu m-cresol) v\u00e0 c\u00e1c phenol kh\u00e1c, l\u1ea5y t\u1eeb nh\u1ef1a than \u0111\u00e1 ho\u1eb7c d\u1ea7u m\u1ecf. Trong b\u00e0o ch\u1ebf, cresol (v\u00e0 m-cresol tinh khi\u1ebft) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n cho thu\u1ed1c ti\u00eam \u2013 quen thu\u1ed9c trong c\u00e1c ch\u1ebf…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2270","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2270"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2270\/revisions"}],"predecessor-version":[{"id":3179,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2270\/revisions\/3179"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2269"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2270"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2270"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}