{"id":2266,"date":"2026-09-27T11:08:25","date_gmt":"2026-09-27T04:08:25","guid":{"rendered":"https:\/\/cpc1.vn\/copovidon-kollidon-va64\/"},"modified":"2026-09-28T21:07:26","modified_gmt":"2026-09-28T14:07:26","slug":"copovidon-kollidon-va64","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/copovidon-kollidon-va64\/","title":{"rendered":"Copovidon (Kollidon VA 64) \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh d\u1eadp th\u1eb3ng, t\u1ea1o m\u00e0ng"},"content":{"rendered":"

Copovidon (Kollidon VA 64) \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh d\u1eadp th\u1eb3ng, t\u1ea1o m\u00e0ng<\/h1>\n

Copovidon<\/strong> (copovidone, PVP\/VA, Kollidon VA 64, Plasdone S-630) l\u00e0 copolyme c\u1ee7a 1-vinyl-2-pyrrolidon v\u00e0 vinyl acetat theo t\u1ef7 l\u1ec7 kh\u1ed1i l\u01b0\u1ee3ng 3:2. So v\u1edbi povidon (PVP), copovidon d\u1ebbo h\u01a1n khi l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh<\/strong>, \u00edt h\u00fat \u1ea9m h\u01a1n<\/strong> v\u00e0 t\u1ea1o m\u00e0ng \u0111\u00e0n h\u1ed3i, \u00edt d\u00ednh h\u01a1n.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nCopolyvidone, PVP\/VA copolymer, poly(1-vinylpyrrolidone-co-vinyl acetate); Kollidon VA 64, Plasdone S-630, Luviskol VA (c\u1ea5p k\u1ef9 thu\u1eadt\/m\u1ef9 ph\u1ea9m)<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n25086-89-9<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c<\/td>\n(C6<\/sub>H9<\/sub>NO)n<\/sub>(C4<\/sub>H6<\/sub>O2<\/sub>)m<\/sub>, n \u2248 1,2m; KLPT 45.000\u201370.000 (Kollidon VA 64)<\/td>\n<\/tr>\n
K-value<\/td>\nKollidon VA 64 danh \u0111\u1ecbnh 28 (25,2\u201330,8); Plasdone S-630 25,4\u201334,2<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o m\u00e0ng, ch\u1ea5t t\u1ea1o h\u1ea1t, t\u00e1 d\u01b0\u1ee3c d\u00ednh vi\u00ean n\u00e9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n\n\n\n\n\n\n\n
Vai tr\u00f2<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
T\u00e1 d\u01b0\u1ee3c d\u00ednh \u2013 d\u1eadp th\u1eb3ng<\/td>\n2,0\u20135,0<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c d\u00ednh \u2013 x\u00e1t h\u1ea1t \u01b0\u1edbt<\/td>\n2,0\u20135,0<\/td>\n<\/tr>\n
T\u1ea1o m\u00e0ng (trong d\u1ecbch bao tr\u01b0\u1edbc khi phun)<\/td>\n0,5\u20135,0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • T\u00e1 d\u01b0\u1ee3c d\u00ednh cho d\u1eadp th\u1eb3ng v\u00e0 x\u00e1t h\u1ea1t \u01b0\u1edbt. Kollidon VA 64 c\u00f3 c\u1ea5u tr\u00fac c\u1ea7u v\u1edbi nhi\u1ec1u c\u1ea7u v\u1ee1 \u2013 l\u00e0m gi\u1ea3m tr\u01a1n ch\u1ea3y nh\u01b0ng bao ph\u1ee7 b\u1ec1 m\u1eb7t t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n r\u1ed9ng h\u01a1n, t\u0103ng hi\u1ec7u qu\u1ea3 d\u00ednh kh\u00f4. V\u1edbi ho\u1ea1t ch\u1ea5t kh\u00f3 n\u00e9n nh\u01b0 paracetamol, Plasdone S-630 cho vi\u00ean c\u1ee9ng h\u01a1n so v\u1edbi cellulose vi tinh th\u1ec3.<\/li>\n
  • Th\u00eam v\u00e0o d\u1ecbch bao l\u00e0m ch\u1ea5t t\u1ea1o m\u00e0ng: b\u00e1m d\u00ednh t\u1ed1t, \u0111\u00e0n h\u1ed3i, c\u1ee9ng; c\u00f3 th\u1ec3 l\u00e0m l\u1edbp ch\u1eafn \u1ea9m.<\/li>\n
  • Th\u00e0nh ph\u1ea7n c\u1ed1t trong c\u00f4ng th\u1ee9c gi\u1ea3i ph\u00f3ng ki\u1ec3m so\u00e1t.<\/li>\n
  • Trong h\u1ec7 qua da, l\u00e0m gi\u1ea3m nhi\u1ec7t n\u00f3ng ch\u1ea3y v\u00e0 nhi\u1ec7t \u0111\u1ed9 n\u00f3ng ch\u1ea3y c\u1ee7a estradiol v\u00e0 c\u00e1c steroid kh\u00e1c.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t v\u00f4 \u0111\u1ecbnh h\u00ecnh tr\u1eafng \u0111\u1ebfn tr\u1eafng ng\u00e0, th\u01b0\u1eddng s\u1ea5y phun, h\u1ea1t kh\u00e1 m\u1ecbn; m\u00f9i nh\u1eb9, v\u1ecb nh\u1ea1t. T\u01b0\u01a1ng \u0111\u1ed1i tr\u01a1n ch\u1ea3y.<\/li>\n
    • T\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,24\u20130,28 g\/cm\u00b3; t\u1ef7 tr\u1ecdng g\u00f5 0,35\u20130,45 g\/cm\u00b3.<\/li>\n
    • Nhi\u1ec7t \u0111\u1ed9 h\u00f3a th\u1ee7y tinh 106 \u00b0C (Plasdone S-630); n\u00f3ng ch\u1ea3y kho\u1ea3ng 140 \u00b0C.<\/li>\n
    • \u1ede 50% RH h\u00fat \u1ea9m d\u01b0\u1edbi 10% kh\u1ed1i l\u01b0\u1ee3ng.<\/li>\n
    • Tan tr\u00ean 10% trong n\u01b0\u1edbc, ethanol 95%, isopropanol, methanol, propylen glycol, glycerol, PEG 400, cloroform, diclomethan\u2026; d\u01b0\u1edbi 1% trong cyclohexan, ether, parafin l\u1ecfng, pentan.<\/li>\n
    • Dung d\u1ecbch n\u01b0\u1edbc d\u01b0\u1edbi 10% c\u00f3 \u0111\u1ed9 nh\u1edbt d\u01b0\u1edbi 10 mPa\u00b7s (25 \u00b0C).<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n; b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng h\u1ee3p v\u1edbi ph\u1ea7n l\u1edbn th\u00e0nh ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m h\u1eefu c\u01a1 v\u00e0 v\u00f4 c\u01a1. Khi c\u00f3 nhi\u1ec1u n\u01b0\u1edbc, copovidon c\u00f3 th\u1ec3 t\u1ea1o ph\u1ee9c ph\u00e2n t\u1eed v\u1edbi m\u1ed9t s\u1ed1 ch\u1ea5t (t\u01b0\u01a1ng t\u1ef1 povidon, crospovidon).<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Tr\u00f9ng h\u1ee3p g\u1ed1c t\u1ef1 do vinylpyrrolidon v\u00e0 vinyl acetat theo t\u1ef7 l\u1ec7 6:4 trong dung m\u00f4i h\u1eefu c\u01a1 (do vinyl acetat kh\u00f4ng tan trong n\u01b0\u1edbc).<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      D\u00f9ng r\u1ed9ng r\u00e3i, \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c; \u0111\u01b0\u1eddng u\u1ed1ng l\u01b0\u1ee3ng l\u1edbn c\u00f3 \u0111\u1ed9c t\u00ednh trung b\u00ecnh, g\u00e2y r\u1ed1i lo\u1ea1n d\u1ea1 d\u00e0y. Kh\u00f4ng k\u00edch \u1ee9ng, kh\u00f4ng g\u00e2y m\u1eabn c\u1ea3m tr\u00ean da. Khi ph\u00e2n h\u1ee7y nhi\u1ec7t t\u1ea1o h\u01a1i NOx<\/sub> \u0111\u1ed9c; d\u00f9ng k\u00ednh, g\u0103ng tay, kh\u1ea9u trang.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • C\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean n\u00e9n u\u1ed1ng, vi\u00ean bao phim, vi\u00ean gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i).<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> povidon, crospovidon.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Copovidone<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Copovidon (Kollidon VA 64) \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh d\u1eadp th\u1eb3ng, t\u1ea1o m\u00e0ng Copovidon (copovidone, PVP\/VA, Kollidon VA 64, Plasdone S-630) l\u00e0 copolyme c\u1ee7a 1-vinyl-2-pyrrolidon v\u00e0 vinyl acetat theo t\u1ef7 l\u1ec7 kh\u1ed1i l\u01b0\u1ee3ng 3:2. So v\u1edbi povidon (PVP), copovidon d\u1ebbo h\u01a1n khi l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh, \u00edt h\u00fat \u1ea9m h\u01a1n v\u00e0 t\u1ea1o m\u00e0ng \u0111\u00e0n h\u1ed3i, \u00edt […]<\/p>","protected":false},"author":1,"featured_media":2265,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2266","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copovidon-kollidon-va64.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copovidon-kollidon-va64-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copovidon-kollidon-va64-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copovidon-kollidon-va64-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copovidon-kollidon-va64-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copovidon-kollidon-va64.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copovidon-kollidon-va64.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copovidon-kollidon-va64-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Copovidon (Kollidon VA 64) \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh d\u1eadp th\u1eb3ng, t\u1ea1o m\u00e0ng Copovidon (copovidone, PVP\/VA, Kollidon VA 64, Plasdone S-630) l\u00e0 copolyme c\u1ee7a 1-vinyl-2-pyrrolidon v\u00e0 vinyl acetat theo t\u1ef7 l\u1ec7 kh\u1ed1i l\u01b0\u1ee3ng 3:2. So v\u1edbi povidon (PVP), copovidon d\u1ebbo h\u01a1n khi l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh, \u00edt h\u00fat \u1ea9m h\u01a1n v\u00e0 t\u1ea1o m\u00e0ng \u0111\u00e0n h\u1ed3i, \u00edt…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2266"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2266\/revisions"}],"predecessor-version":[{"id":3178,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2266\/revisions\/3178"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2265"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}