{"id":2262,"date":"2026-09-27T11:06:36","date_gmt":"2026-09-27T04:06:36","guid":{"rendered":"https:\/\/cpc1.vn\/silic-dioxyd-keo-aerosil\/"},"modified":"2026-09-29T12:14:16","modified_gmt":"2026-09-29T05:14:16","slug":"silic-dioxyd-keo-aerosil","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/silic-dioxyd-keo-aerosil\/","title":{"rendered":"Silic dioxyd keo (Aerosil) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a ch\u1ea3y, ch\u1ed1ng v\u00f3n, l\u00e0m \u0111\u1eb7c"},"content":{"rendered":"

Silic dioxyd keo (Aerosil) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a ch\u1ea3y, ch\u1ed1ng v\u00f3n, l\u00e0m \u0111\u1eb7c<\/h1>\n

Silic dioxyd keo<\/strong> (colloidal silicon dioxide, fumed silica, Aerosil, Cab-O-Sil) l\u00e0 silica v\u00f4 \u0111\u1ecbnh h\u00ecnh “kh\u00f3i”, h\u1ea1t c\u1ef1c nh\u1ecf kho\u1ea3ng 15 nm v\u00e0 di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t r\u1ea5t l\u1edbn. Nh\u1edd v\u1eady, ch\u1ec9 m\u1ed9t l\u01b0\u1ee3ng r\u1ea5t nh\u1ecf \u0111\u00e3 c\u1ea3i thi\u1ec7n r\u00f5 \u0111\u1ed9 tr\u01a1n ch\u1ea3y c\u1ee7a b\u1ed9t \u2013 \u0111\u00e2y l\u00e0 t\u00e1 d\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a ch\u1ea3y<\/strong> ph\u1ed5 bi\u1ebfn nh\u1ea5t trong s\u1ea3n xu\u1ea5t vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nColloidal silica, fumed silica, light anhydrous silicic acid, silicic anhydride; t\u00ean th\u01b0\u01a1ng m\u1ea1i: Aerosil, Cab-O-Sil (M-5P), Wacker HDK<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n7631-86-9<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nSiO2<\/sub> \u2013 60,08<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t h\u1ea5p ph\u1ee5, ch\u1ed1ng v\u00f3n, \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, \u0111i\u1ec1u h\u00f2a ch\u1ea3y, t\u1ea1o h\u1ed7n d\u1ecbch, t\u00e1 d\u01b0\u1ee3c r\u00e3, \u1ed5n \u0111\u1ecbnh nhi\u1ec7t, t\u0103ng \u0111\u1ed9 nh\u1edbt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n\n\n\n\n\n\n\n\n
Vai tr\u00f2<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
T\u00e1 d\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a ch\u1ea3y<\/td>\n0,1\u20130,5<\/td>\n<\/tr>\n
Thu\u1ed1c phun m\u00f9<\/td>\n0,5\u20132,0<\/td>\n<\/tr>\n
\u1ed4n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng<\/td>\n1,0\u20135,0<\/td>\n<\/tr>\n
T\u1ea1o h\u1ed7n d\u1ecbch, l\u00e0m \u0111\u1eb7c<\/td>\n2,0\u201310,0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • \u0110i\u1ec1u h\u00f2a ch\u1ea3y<\/strong> cho b\u1ed9t kh\u00f4 khi d\u1eadp vi\u00ean, \u0111\u00f3ng nang.<\/li>\n
  • L\u00e0m \u0111\u1eb7c x\u00fac bi\u1ebfn<\/strong> cho gel v\u00e0 ch\u1ebf ph\u1ea9m b\u00e1n r\u1eafn; ph\u1ed1i h\u1ee3p th\u00e0nh ph\u1ea7n c\u00f3 chi\u1ebft su\u1ea5t t\u01b0\u01a1ng t\u1ef1 c\u00f3 th\u1ec3 t\u1ea1o gel trong su\u1ed1t. Ch\u1ea5t l\u1ecfng ph\u00e2n c\u1ef1c c\u1ea7n nhi\u1ec1u silica h\u01a1n ch\u1ea5t l\u1ecfng kh\u00f4ng ph\u00e2n c\u1ef1c; \u0111\u1ed9 nh\u1edbt h\u1ea7u nh\u01b0 kh\u00f4ng ph\u1ee5 thu\u1ed9c nhi\u1ec7t \u0111\u1ed9.<\/li>\n
  • Thu\u1ed1c phun m\u00f9<\/strong> (tr\u1eeb lo\u1ea1i h\u00edt): gi\u1eef ti\u1ec3u ph\u00e2n l\u01a1 l\u1eedng, tr\u00e1nh l\u1eafng c\u1ee9ng, h\u1ea1n ch\u1ebf t\u1eafc \u0111\u1ea7u phun.<\/li>\n
  • T\u00e1 d\u01b0\u1ee3c r\u00e3; ch\u1ea5t h\u1ea5p ph\u1ee5 ph\u00e2n t\u00e1n ch\u1ea5t l\u1ecfng v\u00e0o b\u1ed9t (v\u00ed d\u1ee5 tinh d\u1ea7u, vitamin d\u1ea1ng d\u1ea7u).<\/li>\n
  • Thu\u1ed1c \u0111\u1eb7t v\u1edbi t\u00e1 d\u01b0\u1ee3c th\u00e2n d\u1ea7u: t\u0103ng \u0111\u1ed9 nh\u1edbt, h\u1ea1n ch\u1ebf l\u1eafng ho\u1ea1t ch\u1ea5t.<\/li>\n
  • M\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m (ch\u1ed1ng v\u00f3n).<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t v\u00f4 \u0111\u1ecbnh h\u00ecnh r\u1ea5t nh\u1eb9, x\u1ed1p, tr\u1eafng \u00e1nh xanh, kh\u00f4ng m\u00f9i, kh\u00f4ng v\u1ecb, kh\u00f4ng s\u1ea1n; h\u1ea1t s\u01a1 c\u1ea5p 7\u201316 nm.<\/li>\n
    • pH h\u1ec7 ph\u00e2n t\u00e1n 4%: 3,5\u20134,4.<\/li>\n
    • T\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn ch\u1ec9 0,029\u20130,042 g\/cm\u00b3 (lo\u1ea1i “vs” \u2013 n\u00e9n ch\u1eb7t \u2013 kho\u1ea3ng 0,12 g\/cm\u00b3); t\u1ef7 tr\u1ecdng th\u1ef1c 2,2.<\/li>\n
    • Di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t ri\u00eang 50\u2013400 m\u00b2\/g t\u00f9y c\u1ea5p (v\u00ed d\u1ee5 Aerosil 130, 200, 300, 380; Cab-O-Sil M-5 kho\u1ea3ng 200 m\u00b2\/g).<\/li>\n
    • Kh\u00f4ng tan trong dung m\u00f4i h\u1eefu c\u01a1, n\u01b0\u1edbc v\u00e0 acid (tr\u1eeb acid hydrofluoric); tan trong dung d\u1ecbch hydroxyd ki\u1ec1m n\u00f3ng; t\u1ea1o h\u1ec7 ph\u00e2n t\u00e1n keo trong n\u01b0\u1edbc.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • H\u00fat \u1ea9m nh\u01b0ng h\u1ea5p ph\u1ee5 l\u01b0\u1ee3ng n\u01b0\u1edbc l\u1edbn m\u00e0 kh\u00f4ng h\u00f3a l\u1ecfng; c\u00f3 c\u1ea5p x\u1eed l\u00fd b\u1ec1 m\u1eb7t k\u1ef5 n\u01b0\u1edbc gi\u1ea3m h\u00fat \u1ea9m.<\/li>\n
      • Trong h\u1ec7 n\u01b0\u1edbc, l\u00e0m t\u0103ng \u0111\u1ed9 nh\u1edbt hi\u1ec7u qu\u1ea3 \u1edf pH 0\u20137,5; tr\u00ean 7,5 gi\u1ea3m t\u00e1c d\u1ee5ng, tr\u00ean 10,7 m\u1ea5t ho\u00e0n to\u00e0n do silica tan th\u00e0nh silicat.<\/li>\n
      • B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn. M\u1ee9c nhi\u1ec5m vi sinh th\u01b0\u1eddng r\u1ea5t th\u1ea5p.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ebf ph\u1ea9m diethylstilbestrol.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Th\u1ee7y ph\u00e2n pha h\u01a1i c\u00e1c clorosilan (nh\u01b0 silic tetraclorid) \u1edf kho\u1ea3ng 1800 \u00b0C trong ng\u1ecdn l\u1eeda hydro\u2013oxy. Thay \u0111\u1ed5i \u0111i\u1ec1u ki\u1ec7n s\u1ea3n xu\u1ea5t cho c\u00e1c c\u1ea5p kh\u00e1c nhau v\u1ec1 c\u1ee1 h\u1ea1t, di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t, t\u1ef7 tr\u1ecdng (kh\u00f4ng \u0111\u1ed5i h\u00e0m l\u01b0\u1ee3ng silica, t\u1ef7 tr\u1ecdng th\u1ef1c, chi\u1ebft su\u1ea5t, t\u00ednh v\u00f4 \u0111\u1ecbnh h\u00ecnh).<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        D\u00f9ng r\u1ed9ng r\u00e3i trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i, \u0111\u01b0\u1ee3c xem l\u00e0 g\u1ea7n nh\u01b0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. Ti\u00eam ph\u00fac m\u1ea1c, d\u01b0\u1edbi da c\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng m\u00f4 t\u1ea1i ch\u1ed7, u h\u1ea1t \u2013 kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam<\/strong>. H\u00edt b\u1ee5i c\u00f3 th\u1ec3 k\u00edch \u1ee9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p nh\u01b0ng kh\u00f4ng g\u00e2y x\u01a1 ph\u1ed5i (b\u1ec7nh b\u1ee5i ph\u1ed5i silic) nh\u01b0 silica tinh th\u1ec3. Do b\u1ed9t r\u1ea5t nh\u1eb9, d\u1ec5 bay: d\u00f9ng k\u00ednh, g\u0103ng tay, kh\u1ea9u trang (l\u01b0\u1ee3ng nh\u1ecf) ho\u1eb7c m\u1eb7t n\u1ea1 ch\u1ed1ng b\u1ee5i (l\u01b0\u1ee3ng l\u1edbn), \u01b0u ti\u00ean thao t\u00e1c trong h\u1ec7 k\u00edn.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • FDA x\u1ebfp nh\u00f3m GRAS; c\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean nang, h\u1ed7n d\u1ecbch, vi\u00ean n\u00e9n u\u1ed1ng; qua da; \u00e2m \u0111\u1ea1o).<\/li>\n
        • C\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. (k\u1ec3 c\u1ea3 silic dioxyd keo ng\u1eadm n\u01b0\u1edbc) v\u00e0 USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> cellulose vi tinh th\u1ec3 silic h\u00f3a, talc, magnesi silicat.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Colloidal Silicon Dioxide<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Silic dioxyd keo (Aerosil) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a ch\u1ea3y, ch\u1ed1ng v\u00f3n, l\u00e0m \u0111\u1eb7c Silic dioxyd keo (colloidal silicon dioxide, fumed silica, Aerosil, Cab-O-Sil) l\u00e0 silica v\u00f4 \u0111\u1ecbnh h\u00ecnh “kh\u00f3i”, h\u1ea1t c\u1ef1c nh\u1ecf kho\u1ea3ng 15 nm v\u00e0 di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t r\u1ea5t l\u1edbn. Nh\u1edd v\u1eady, ch\u1ec9 m\u1ed9t l\u01b0\u1ee3ng r\u1ea5t nh\u1ecf \u0111\u00e3 c\u1ea3i thi\u1ec7n r\u00f5 \u0111\u1ed9 […]<\/p>\n","protected":false},"author":1,"featured_media":2261,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2262","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silic-dioxyd-keo-aerosil.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silic-dioxyd-keo-aerosil-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silic-dioxyd-keo-aerosil-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silic-dioxyd-keo-aerosil-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silic-dioxyd-keo-aerosil-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silic-dioxyd-keo-aerosil.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silic-dioxyd-keo-aerosil.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silic-dioxyd-keo-aerosil-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Silic dioxyd keo (Aerosil) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a ch\u1ea3y, ch\u1ed1ng v\u00f3n, l\u00e0m \u0111\u1eb7c Silic dioxyd keo (colloidal silicon dioxide, fumed silica, Aerosil, Cab-O-Sil) l\u00e0 silica v\u00f4 \u0111\u1ecbnh h\u00ecnh “kh\u00f3i”, h\u1ea1t c\u1ef1c nh\u1ecf kho\u1ea3ng 15 nm v\u00e0 di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t r\u1ea5t l\u1edbn. Nh\u1edd v\u1eady, ch\u1ec9 m\u1ed9t l\u01b0\u1ee3ng r\u1ea5t nh\u1ecf \u0111\u00e3 c\u1ea3i thi\u1ec7n r\u00f5 \u0111\u1ed9…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2262"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2262\/revisions"}],"predecessor-version":[{"id":3956,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2262\/revisions\/3956"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2261"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}