{"id":2260,"date":"2026-09-27T11:06:28","date_gmt":"2026-09-27T04:06:28","guid":{"rendered":"https:\/\/cpc1.vn\/acid-citric-monohydrat\/"},"modified":"2026-09-29T11:50:56","modified_gmt":"2026-09-29T04:50:56","slug":"acid-citric-monohydrat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/acid-citric-monohydrat\/","title":{"rendered":"Acid citric monohydrat v\u00e0 khan (E330) \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m, t\u1ea1o ph\u1ee9c"},"content":{"rendered":"

Acid citric monohydrat v\u00e0 khan (E330) \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m, t\u1ea1o ph\u1ee9c<\/h1>\n

Acid citric<\/strong> (E330) l\u00e0 acid h\u1eefu c\u01a1 ba n\u1ea5c c\u00f3 s\u1eb5n trong nhi\u1ec1u lo\u1ea1i qu\u1ea3. \u1ede d\u1ea1ng monohydrat<\/strong> hay khan<\/strong>, acid citric \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m, ch\u1ee7 y\u1ebfu \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh pH, l\u00e0m dung d\u1ecbch \u0111\u1ec7m, t\u1ea1o ph\u1ee9c kim lo\u1ea1i, t\u0103ng v\u1ecb \u2013 v\u00e0 l\u00e0 “th\u00e0nh ph\u1ea7n acid” kinh \u0111i\u1ec3n c\u1ee7a vi\u00ean, c\u1ed1m s\u1ee7i b\u1ecdt.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n\n\n\n
<\/th>\nMonohydrat<\/th>\nKhan<\/th>\n<\/tr>\n<\/thead>\n
C\u00f4ng th\u1ee9c<\/td>\nC6<\/sub>H8<\/sub>O7<\/sub>\u00b7H2<\/sub>O<\/td>\nC6<\/sub>H8<\/sub>O7<\/sub><\/td>\n<\/tr>\n
KLPT<\/td>\n210,14<\/td>\n192,12<\/td>\n<\/tr>\n
CAS<\/td>\n5949-29-1<\/td>\n77-92-9<\/td>\n<\/tr>\n
Tinh th\u1ec3<\/td>\nTr\u1ef1c thoi<\/td>\n\u0110\u01a1n t\u00e0<\/td>\n<\/tr>\n
N\u00f3ng ch\u1ea3y<\/td>\nkho\u1ea3ng 100 \u00b0C (m\u1ec1m \u1edf 75 \u00b0C)<\/td>\n153 \u00b0C<\/td>\n<\/tr>\n
T\u1ef7 tr\u1ecdng<\/td>\n1,542 g\/cm\u00b3<\/td>\n1,665 g\/cm\u00b3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

T\u00ean h\u00f3a h\u1ecdc: acid 2-hydroxy-1,2,3-propantricarboxylic. JP v\u00e0 Ph.Eur. c\u00f3 chuy\u00ean lu\u1eadn ri\u00eang cho hai d\u1ea1ng; USP g\u1ed9p chung m\u1ed9t chuy\u00ean lu\u1eadn. Nh\u00f3m ch\u1ee9c n\u0103ng: ch\u1ea5t acid h\u00f3a, ch\u1ed1ng oxy h\u00f3a (hi\u1ec7p \u0111\u1ed3ng), \u0111\u1ec7m, t\u1ea1o ph\u1ee9c, t\u0103ng v\u1ecb.<\/p>\n

\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n\n\n\n\n\n\n\n
Vai tr\u00f2<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
Dung d\u1ecbch \u0111\u1ec7m<\/td>\n0,1\u20132,0<\/td>\n<\/tr>\n
T\u0103ng v\u1ecb cho ch\u1ebf ph\u1ea9m l\u1ecfng<\/td>\n0,3\u20132,0<\/td>\n<\/tr>\n
Ch\u1ea5t t\u1ea1o ph\u1ee9c (c\u00f4 l\u1eadp ion kim lo\u1ea1i)<\/td>\n0,3\u20132,0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • \u0110i\u1ec1u ch\u1ec9nh pH dung d\u1ecbch \u2013 \u1ee9ng d\u1ee5ng ch\u00ednh.<\/li>\n
  • S\u1ee7i b\u1ecdt<\/strong>: d\u1ea1ng monohydrat th\u01b0\u1eddng d\u00f9ng cho c\u1ed1m s\u1ee7i b\u1ecdt, d\u1ea1ng khan d\u00f9ng r\u1ed9ng r\u00e3i cho vi\u00ean s\u1ee7i b\u1ecdt (\u00edt n\u01b0\u1edbc, h\u1ea1n ch\u1ebf ph\u1ea3n \u1ee9ng s\u1edbm v\u1edbi bicarbonat).<\/li>\n
  • Th\u1ef1c nghi\u1ec7m: \u0111i\u1ec1u ch\u1ec9nh pH vi m\u00f4i tr\u01b0\u1eddng trong c\u1ed1t vi\u00ean bao tan trong ru\u1ed9t \u0111\u01b0a thu\u1ed1c \u0111\u1ebfn \u0111\u1ea1i tr\u00e0ng.<\/li>\n
  • Ch\u1ea5t hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng oxy h\u00f3a (t\u1ea1o ph\u1ee9c kim lo\u1ea1i x\u00fac t\u00e1c oxy h\u00f3a) c\u00f9ng BHA, BHT\u2026<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Tinh th\u1ec3 kh\u00f4ng m\u00e0u ho\u1eb7c trong m\u1edd, ho\u1eb7c b\u1ed9t k\u1ebft tinh tr\u1eafng; kh\u00f4ng m\u00f9i, v\u1ecb chua m\u1ea1nh.<\/li>\n
    • pH dung d\u1ecbch 1%: 2,2. pKa1<\/sub> 3,128; pKa2<\/sub> 4,761; pKa3<\/sub> 6,396 (25 \u00b0C) \u2013 cho kh\u1ea3 n\u0103ng \u0111\u1ec7m r\u1ed9ng kho\u1ea3ng pH 2,5\u20136,5.<\/li>\n
    • Monohydrat: tan d\u01b0\u1edbi 1 ph\u1ea7n n\u01b0\u1edbc, 1\/1,5 trong ethanol 95%; kh\u00f3 tan trong ether. D\u1ea1ng khan tan 1\/1 trong n\u01b0\u1edbc v\u00e0 ethanol.<\/li>\n
    • \u0110\u1ed9 nh\u1edbt dung d\u1ecbch 50%: 6,5 mPa\u00b7s (25 \u00b0C).<\/li>\n<\/ul>\n

      H\u00fat \u1ea9m \u2013 \u0111i\u1ec3m c\u1ea7n l\u01b0u \u00fd khi l\u00e0m vi\u00ean s\u1ee7i<\/h2>\n
        \n
      • Monohydrat<\/strong>: d\u01b0\u1edbi kho\u1ea3ng 65% RH b\u1ecb l\u00ean hoa (m\u1ea5t n\u01b0\u1edbc k\u1ebft tinh), d\u01b0\u1edbi kho\u1ea3ng 40% RH chuy\u1ec3n th\u00e0nh d\u1ea1ng khan; 65\u201375% RH h\u00fat \u1ea9m kh\u00f4ng \u0111\u00e1ng k\u1ec3; tr\u00ean 75% RH h\u00fat nhi\u1ec1u n\u01b0\u1edbc.<\/li>\n
      • Khan<\/strong>: 25\u201350% RH h\u00fat \u1ea9m kh\u00f4ng \u0111\u00e1ng k\u1ec3; 50\u201375% RH h\u00fat \u0111\u00e1ng k\u1ec3, g\u1ea7n 75% RH chuy\u1ec3n th\u00e0nh monohydrat.<\/li>\n
      • Monohydrat m\u1ea5t n\u01b0\u1edbc k\u1ebft tinh trong kh\u00f4ng kh\u00ed kh\u00f4 ho\u1eb7c khi \u0111un kho\u1ea3ng 40 \u00b0C; h\u01a1i ch\u1ea3y r\u1eefa trong kh\u00f4ng kh\u00ed \u1ea9m.<\/li>\n<\/ul>\n

        \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

        Dung d\u1ecbch acid citric lo\u00e3ng c\u00f3 th\u1ec3 l\u00ean men khi \u0111\u1ec3 l\u00e2u. Nguy\u00ean li\u1ec7u (c\u1ea3 hai d\u1ea1ng) b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n
          \n
        • Kali tartrat; carbonat v\u00e0 bicarbonat ki\u1ec1m, ki\u1ec1m th\u1ed5 (s\u1ee7i b\u1ecdt); acetat; sulfid.<\/li>\n
        • Ch\u1ea5t oxy h\u00f3a, base, ch\u1ea5t kh\u1eed, nitrat; c\u00f3 th\u1ec3 g\u00e2y n\u1ed5 khi tr\u1ed9n v\u1edbi nitrat kim lo\u1ea1i.<\/li>\n
        • Trong siro, acid citric c\u00f3 th\u1ec3 l\u00e0m saccarose k\u1ebft tinh khi b\u1ea3o qu\u1ea3n.<\/li>\n<\/ul>\n

          S\u1ea3n xu\u1ea5t<\/h2>\n

          Chi\u1ebft t\u1eeb n\u01b0\u1edbc chanh (ch\u1ee9a 5\u20138% acid citric) ho\u1eb7c ph\u1ebf ph\u1ea9m d\u1ee9a; c\u00f4ng nghi\u1ec7p ch\u1ee7 y\u1ebfu l\u00ean men dung d\u1ecbch \u0111\u01b0\u1eddng th\u00f4 (r\u1ec9 \u0111\u01b0\u1eddng) b\u1eb1ng ch\u1ee7ng Aspergillus niger<\/em>. K\u1ebft tinh l\u1ea1i t\u1eeb dung d\u1ecbch \u0111\u1eadm \u0111\u1eb7c n\u00f3ng cho d\u1ea1ng khan, t\u1eeb dung d\u1ecbch \u0111\u1eadm \u0111\u1eb7c l\u1ea1nh cho d\u1ea1ng monohydrat.<\/p>\n

          An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

          Acid citric c\u00f3 s\u1eb5n trong c\u01a1 th\u1ec3 v\u00e0 kh\u1ea9u ph\u1ea7n \u0103n; v\u1edbi vai tr\u00f2 t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c. D\u00f9ng th\u01b0\u1eddng xuy\u00ean, l\u01b0\u1ee3ng l\u1edbn c\u00f3 li\u00ean quan \u0111\u1ebfn m\u00f2n men r\u0103ng. Acid citric v\u00e0 citrat l\u00e0m t\u0103ng h\u1ea5p thu nh\u00f4m \u1edf ru\u1ed9t \u2013 ng\u01b0\u1eddi suy th\u1eadn \u0111ang d\u00f9ng h\u1ee3p ch\u1ea5t nh\u00f4m \u0111\u1ec3 ki\u1ec3m so\u00e1t phosphat kh\u00f4ng n\u00ean d\u00f9ng ch\u1ebf ph\u1ea9m ch\u1ee9a citrat. Ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi m\u1eaft c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng n\u1eb7ng \u2013 d\u00f9ng k\u00ednh, g\u0103ng tay, l\u00e0m vi\u1ec7c n\u01a1i th\u00f4ng gi\u00f3 ho\u1eb7c \u0111eo kh\u1ea9u trang.<\/p>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • FDA x\u1ebfp nh\u00f3m GRAS; c\u00f3 trong FDA Inactive Ingredients Guide (h\u00edt; ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch v\u00e0 ti\u00eam kh\u00e1c; nh\u1ecf m\u1eaft; vi\u00ean nang, dung d\u1ecbch, h\u1ed7n d\u1ecbch, vi\u00ean n\u00e9n u\u1ed1ng; d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o).<\/li>\n
          • D\u1ea1ng khan \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E330); c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
          • C\u00f3 chuy\u00ean lu\u1eadn trong JP, Ph.Eur., USP; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan:<\/strong> acid fumaric, acid malic, natri citrat dihydrat, acid tartaric.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Citric Acid Monohydrate<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Acid citric monohydrat v\u00e0 khan (E330) \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m, t\u1ea1o ph\u1ee9c Acid citric (E330) l\u00e0 acid h\u1eefu c\u01a1 ba n\u1ea5c c\u00f3 s\u1eb5n trong nhi\u1ec1u lo\u1ea1i qu\u1ea3. \u1ede d\u1ea1ng monohydrat hay khan, acid citric \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m, ch\u1ee7 y\u1ebfu \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh pH, l\u00e0m dung d\u1ecbch \u0111\u1ec7m, […]<\/p>\n","protected":false},"author":1,"featured_media":2259,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2260","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-citric-monohydrat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-citric-monohydrat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-citric-monohydrat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-citric-monohydrat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-citric-monohydrat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-citric-monohydrat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-citric-monohydrat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-citric-monohydrat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Acid citric monohydrat v\u00e0 khan (E330) \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m, t\u1ea1o ph\u1ee9c Acid citric (E330) l\u00e0 acid h\u1eefu c\u01a1 ba n\u1ea5c c\u00f3 s\u1eb5n trong nhi\u1ec1u lo\u1ea1i qu\u1ea3. \u1ede d\u1ea1ng monohydrat hay khan, acid citric \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m, ch\u1ee7 y\u1ebfu \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh pH, l\u00e0m dung d\u1ecbch \u0111\u1ec7m,…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2260"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2260\/revisions"}],"predecessor-version":[{"id":3712,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2260\/revisions\/3712"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2259"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}