{"id":2244,"date":"2026-09-27T11:00:51","date_gmt":"2026-09-27T04:00:51","guid":{"rendered":"https:\/\/cpc1.vn\/cetylpyridinium-clorid\/"},"modified":"2026-09-28T21:06:33","modified_gmt":"2026-09-28T14:06:33","slug":"cetylpyridinium-clorid","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/cetylpyridinium-clorid\/","title":{"rendered":"Cetylpyridinium clorid (CPC) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, di\u1ec7n ho\u1ea1t cation"},"content":{"rendered":"

Cetylpyridinium clorid (CPC) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, di\u1ec7n ho\u1ea1t cation<\/h1>\n

Cetylpyridinium clorid<\/strong> (CPC, hexadecylpyridinium clorid) l\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t cation amoni b\u1eadc b\u1ed1n, d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n; n\u1ed5i ti\u1ebfng nh\u1ea5t l\u00e0 th\u00e0nh ph\u1ea7n s\u00e1t khu\u1ea9n c\u1ee7a n\u01b0\u1edbc s\u00fac mi\u1ec7ng v\u00e0 vi\u00ean ng\u1eadm h\u1ecdng.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nHexadecylpyridinium chloride, C16-alkylpyridinium chloride; t\u00ean th\u01b0\u01a1ng m\u1ea1i: Cepacol, Dobendan, Pristacin, Pyrisept<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n123-03-5 (khan); 6004-24-6 (monohydrat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC21<\/sub>H38<\/sub>ClN \u2013 339,9 (khan); C21<\/sub>H38<\/sub>ClN\u00b7H2<\/sub>O \u2013 358,1<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, s\u00e1t khu\u1ea9n, di\u1ec7n ho\u1ea1t cation, h\u00f2a tan, g\u00e2y th\u1ea5m<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m.<\/li>\n
  • Ch\u1ea5t s\u00e1t khu\u1ea9n cho khoang mi\u1ec7ng v\u00e0 h\u1ecdng, ri\u00eang l\u1ebb ho\u1eb7c ph\u1ed1i h\u1ee3p; c\u00f3 trong thu\u1ed1c u\u1ed1ng v\u00e0 thu\u1ed1c h\u00edt v\u1edbi l\u01b0\u1ee3ng 0,02\u20131,5 mg.<\/li>\n
  • N\u01b0\u1edbc s\u00fac mi\u1ec7ng ch\u1ee9a CPC \u0111\u01b0\u1ee3c ch\u1ee9ng minh \u1ee9c ch\u1ebf h\u00ecnh th\u00e0nh m\u1ea3ng b\u00e1m (d\u1eef li\u1ec7u c\u00f4ng b\u1ed1 c\u00f2n h\u1ea1n ch\u1ebf).<\/li>\n
  • T\u1eebng \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n cho th\u1ecbt, rau qu\u1ea3, nh\u01b0ng t\u1ed3n d\u01b0 sau x\u1eed l\u00fd \u0111\u01b0\u1ee3c xem l\u00e0 qu\u00e1 cao.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng, m\u00f9i \u0111\u1eb7c tr\u01b0ng, s\u1edd h\u01a1i tr\u01a1n nh\u01b0 x\u00e0 ph\u00f2ng.<\/li>\n
    • N\u00f3ng ch\u1ea3y 80\u201383 \u00b0C; n\u1ed3ng \u0111\u1ed9 micelle t\u1edbi h\u1ea1n 0,34 g\/L (n\u01b0\u1edbc, 25 \u00b0C).<\/li>\n
    • T\u00e1c d\u1ee5ng m\u1ea1nh tr\u00ean vi khu\u1ea9n Gram d\u01b0\u01a1ng; t\u01b0\u01a1ng \u0111\u1ed1i k\u00e9m hi\u1ec7u qu\u1ea3 tr\u00ean m\u1ed9t s\u1ed1 Gram \u00e2m; c\u00f3 t\u00e1c d\u1ee5ng tr\u00ean nhi\u1ec1u vi khu\u1ea9n khoang mi\u1ec7ng (MIC d\u01b0\u1edbi 2 \u00b5g\/mL v\u1edbi S. aureus<\/em>, B. subtilis<\/em>, S. pyogenes<\/em>; 16 \u00b5g\/mL v\u1edbi P. aeruginosa<\/em>).<\/li>\n
    • D\u1ec5 tan trong n\u01b0\u1edbc, r\u1ea5t d\u1ec5 tan trong cloroform; r\u1ea5t kh\u00f3 tan trong ether.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n trong \u0111i\u1ec1u ki\u1ec7n th\u01b0\u1eddng; b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • Ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 base; methylcellulose.<\/li>\n
      • Magnesi stearat<\/strong> h\u1ea5p ph\u1ee5 CPC, l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n \u2013 c\u1ea7n l\u01b0u \u00fd khi l\u00e0m vi\u00ean ng\u1eadm.<\/li>\n
      • Ion CPC t\u01b0\u01a1ng t\u00e1c v\u1edbi gelatin, l\u00e0m gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Cho cetyl clorid ph\u1ea3n \u1ee9ng v\u1edbi pyridin.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        \u1ede n\u1ed3ng \u0111\u1ed9 0,05% trong n\u01b0\u1edbc s\u00fac mi\u1ec7ng, CPC \u0111\u01b0\u1ee3c xem l\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i kh\u00f4ng \u0111\u1ed9c, c\u00f3 th\u1ec3 g\u00e2y r\u00e1t nh\u1eb9 tr\u00ean l\u01b0\u1ee1i. N\u1ed3ng \u0111\u1ed9 cao h\u01a1n c\u00f3 th\u1ec3 t\u1ed5n th\u01b0\u01a1ng ni\u00eam m\u1ea1c mi\u1ec7ng. CPC c\u00f3 h\u1ea1i khi nu\u1ed1t ho\u1eb7c h\u00edt; k\u00edch \u1ee9ng m\u1eaft, h\u00f4 h\u1ea5p, da. Khi thao t\u00e1c l\u01b0\u1ee3ng l\u1edbn d\u00f9ng m\u1eb7t n\u1ea1 c\u00f3 phin l\u1ecdc ph\u00f9 h\u1ee3p, k\u00ednh, g\u0103ng tay, th\u00f4ng gi\u00f3 t\u1ed1t; \u0111un \u0111\u1ebfn ph\u00e2n h\u1ee7y t\u1ecfa kh\u00ed r\u1ea5t \u0111\u1ed9c (NOx<\/sub>, Cl\u207b).<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c h\u00edt, thu\u1ed1c u\u1ed1ng).<\/li>\n
        • C\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada; kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e9p t\u1ea1i Nh\u1eadt B\u1ea3n (theo th\u00f4ng tin n\u0103m 2006).<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> benzalkonium clorid, benzethonium clorid, cetrimid.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Cetylpyridinium Chloride<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Cetylpyridinium clorid (CPC) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, di\u1ec7n ho\u1ea1t cation Cetylpyridinium clorid (CPC, hexadecylpyridinium clorid) l\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t cation amoni b\u1eadc b\u1ed1n, d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n; n\u1ed5i ti\u1ebfng nh\u1ea5t l\u00e0 th\u00e0nh ph\u1ea7n s\u00e1t khu\u1ea9n c\u1ee7a n\u01b0\u1edbc s\u00fac mi\u1ec7ng v\u00e0 vi\u00ean ng\u1eadm h\u1ecdng. Th\u00f4ng tin nhanh […]<\/p>","protected":false},"author":1,"featured_media":2243,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2244","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetylpyridinium-clorid.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetylpyridinium-clorid-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetylpyridinium-clorid-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetylpyridinium-clorid-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetylpyridinium-clorid-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetylpyridinium-clorid.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetylpyridinium-clorid.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetylpyridinium-clorid-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Cetylpyridinium clorid (CPC) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, di\u1ec7n ho\u1ea1t cation Cetylpyridinium clorid (CPC, hexadecylpyridinium clorid) l\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t cation amoni b\u1eadc b\u1ed1n, d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n; n\u1ed5i ti\u1ebfng nh\u1ea5t l\u00e0 th\u00e0nh ph\u1ea7n s\u00e1t khu\u1ea9n c\u1ee7a n\u01b0\u1edbc s\u00fac mi\u1ec7ng v\u00e0 vi\u00ean ng\u1eadm h\u1ecdng. Th\u00f4ng tin nhanh…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2244"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2244\/revisions"}],"predecessor-version":[{"id":3168,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2244\/revisions\/3168"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2243"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2244"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2244"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}