{"id":2240,"date":"2026-09-27T10:59:40","date_gmt":"2026-09-27T03:59:40","guid":{"rendered":"https:\/\/cpc1.vn\/cetrimid\/"},"modified":"2026-09-27T10:59:40","modified_gmt":"2026-09-27T03:59:40","slug":"cetrimid","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/cetrimid\/","title":{"rendered":"Cetrimid (Cetrimide) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, ch\u1ea5t di\u1ec7n ho\u1ea1t cation"},"content":{"rendered":"

Cetrimid (Cetrimide) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, ch\u1ea5t di\u1ec7n ho\u1ea1t cation<\/h1>\n

Cetrimid<\/strong> (cetrimide, Cetavlon) l\u00e0 h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n \u2013 ch\u1ea5t di\u1ec7n ho\u1ea1t cation \u2013 d\u00f9ng trong m\u1ef9 ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n v\u00e0 ch\u1ea5t s\u00e1t khu\u1ea9n d\u00f9ng ngo\u00e0i.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nCetavlon, Cetab, Bromat, Cetraol, Lissolamine V, Morpan CHSA, Quammonium<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n8044-71-1 (cetrimid Ph.Eur.)<\/td>\n<\/tr>\n
Th\u00e0nh ph\u1ea7n<\/td>\nCh\u1ee7 y\u1ebfu trimethyltetradecylamoni bromid (C17<\/sub>H38<\/sub>BrN, 336,40), k\u00e8m l\u01b0\u1ee3ng nh\u1ecf dodecyltrimethylamoni bromid (C12) v\u00e0 hexadecyltrimethylamoni bromid (C16, CTAB)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t s\u00e1t khu\u1ea9n, ch\u1ea5t di\u1ec7n ho\u1ea1t cation<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

L\u01b0u \u00fd v\u1ec1 danh ph\u00e1p:<\/strong> t\u00e0i li\u1ec7u th\u01b0\u1eddng nh\u1ea7m l\u1eabn CAS v\u00e0 KLPT c\u1ee7a cetrimid. Cetrimid BP 1953 nguy\u00ean th\u1ee7y ch\u1ee7 y\u1ebfu l\u00e0 hexadecyltrimethylamoni bromid (CTAB, CAS 57-09-0) v\u00e0 ch\u1ee9a nhi\u1ec1u mu\u1ed1i v\u00f4 c\u01a1; cetrimid hi\u1ec7n nay ch\u1ee7 y\u1ebfu l\u00e0 d\u1eabn ch\u1ea5t C14 (CAS 1119-97-7). C\u1ea7n \u0111\u1ed1i chi\u1ebfu \u0111\u00fang ti\u00eau chu\u1ea9n tr\u00ean COA.<\/p>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t b\u1ea3o qu\u1ea3n trong m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c; trong thu\u1ed1c nh\u1ecf m\u1eaft d\u00f9ng \u1edf 0,005%<\/strong>.<\/li>\n
  • Ch\u1ea5t di\u1ec7n ho\u1ea1t cation; th\u00e0nh ph\u1ea7n c\u1ee7a s\u00e1p nh\u0169 h\u00f3a cetrimid v\u00e0 kem d\u1ea7u\/n\u01b0\u1edbc.<\/li>\n
  • Dung d\u1ecbch 0,1\u20131,0% l\u00e0 ch\u1ea5t s\u00e1t khu\u1ea9n d\u00f9ng ngo\u00e0i cho da; dung d\u1ecbch 1\u20133% d\u00f9ng trong d\u1ea7u g\u1ed9i l\u00e0m s\u1ea1ch v\u1ea3y da \u0111\u1ea7u.<\/li>\n
  • L\u00e0m s\u1ea1ch, s\u00e1t khu\u1ea9n k\u00ednh \u00e1p tr\u00f2ng c\u1ee9ng \u2013 kh\u00f4ng d\u00f9ng cho k\u00ednh m\u1ec1m<\/strong>.<\/li>\n<\/ul>\n

    Ph\u1ed5 kh\u00e1ng khu\u1ea9n<\/h2>\n
      \n
    • Di\u1ec7t t\u1ed1t vi khu\u1ea9n Gram d\u01b0\u01a1ng, y\u1ebfu h\u01a1n tr\u00ean Gram \u00e2m; Pseudomonas aeruginosa<\/em> c\u00f3 th\u1ec3 \u0111\u1ec1 kh\u00e1ng.<\/li>\n
    • Hi\u1ec7u qu\u1ea3 nh\u1ea5t \u1edf pH trung t\u00ednh ho\u1eb7c h\u01a1i ki\u1ec1m; gi\u1ea3m r\u00f5 trong m\u00f4i tr\u01b0\u1eddng acid v\u00e0 khi c\u00f3 ch\u1ea5t h\u1eefu c\u01a1; t\u0103ng khi c\u00f3 alcol.<\/li>\n
    • T\u00e1c d\u1ee5ng tr\u00ean n\u1ea5m kh\u00f4ng \u1ed5n \u0111\u1ecbnh; c\u00f3 t\u00e1c d\u1ee5ng tr\u00ean m\u1ed9t s\u1ed1 virus; kh\u00f4ng t\u00e1c d\u1ee5ng tr\u00ean b\u00e0o t\u1eed.<\/li>\n
    • \u0110\u1ec3 ph\u00f2ng nhi\u1ec5m Pseudomonas<\/em> kh\u00e1ng cetrimid, dung d\u1ecbch g\u1ed1c c\u00f3 th\u1ec3 th\u00eam \u00edt nh\u1ea5t 7% ethanol ho\u1eb7c 4% isopropanol.<\/li>\n<\/ul>\n

      M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
        \n
      • B\u1ed9t tr\u01a1n ch\u1ea3y, tr\u1eafng \u0111\u1ebfn tr\u1eafng kem; m\u00f9i nh\u1eb9 \u0111\u1eb7c tr\u01b0ng, v\u1ecb \u0111\u1eafng nh\u01b0 x\u00e0 ph\u00f2ng.<\/li>\n
      • pH dung d\u1ecbch 1%: 5,0\u20137,5; n\u1ed3ng \u0111\u1ed9 micelle t\u1edbi h\u1ea1n kho\u1ea3ng 0,01%; n\u00f3ng ch\u1ea3y 232\u2013247 \u00b0C.<\/li>\n
      • R\u1ea5t d\u1ec5 tan trong n\u01b0\u1edbc, ethanol, cloroform; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ether. Dung d\u1ecbch 2% t\u1ea1o nhi\u1ec1u b\u1ecdt khi l\u1eafc.<\/li>\n
      • \u1ede 40\u201350% RH (20 \u00b0C) h\u00fat \u1ea9m \u0111\u1ee7 \u0111\u1ec3 v\u00f3n c\u1ee5c, gi\u1ea3m tr\u01a1n ch\u1ea3y.<\/li>\n<\/ul>\n

        \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

        B\u1ec1n \u1edf d\u1ea1ng kh\u00f4 v\u00e0 trong dung d\u1ecbch n\u01b0\u1edbc \u1edf nhi\u1ec7t \u0111\u1ed9 th\u01b0\u1eddng; dung d\u1ecbch c\u00f3 th\u1ec3 h\u1ea5p ti\u1ec7t khu\u1ea9n. N\u01b0\u1edbc ch\u1ee9a ion kim lo\u1ea1i v\u00e0 ch\u1ea5t h\u1eefu c\u01a1 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ho\u1ea1t t\u00ednh. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        X\u00e0 ph\u00f2ng, ch\u1ea5t di\u1ec7n ho\u1ea1t anion, ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion h\u00f3a n\u1ed3ng \u0111\u1ed9 cao, bentonit, iod, phenylmercuric nitrat, hydroxyd ki\u1ec1m, ph\u1ea9m m\u00e0u acid. Dung d\u1ecbch n\u01b0\u1edbc ph\u1ea3n \u1ee9ng v\u1edbi kim lo\u1ea1i.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Ng\u01b0ng t\u1ee5 c\u00e1c alkyl bromid th\u00edch h\u1ee3p v\u1edbi trimethylamin.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        \u1ede n\u1ed3ng \u0111\u1ed9 d\u00f9ng ngo\u00e0i, dung d\u1ecbch th\u01b0\u1eddng kh\u00f4ng g\u00e2y k\u00edch \u1ee9ng, nh\u01b0ng dung d\u1ecbch \u0111\u1eadm \u0111\u1eb7c \u0111\u00f4i khi g\u00e2y b\u1ecfng; \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o qu\u00e1 m\u1eabn khi d\u00f9ng l\u1eb7p l\u1ea1i. Nu\u1ed1t ph\u1ea3i c\u00f3 th\u1ec3 g\u00e2y bu\u1ed3n n\u00f4n, n\u00f4n, li\u1ec7t c\u01a1, \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng, t\u1ee5t huy\u1ebft \u00e1p; li\u1ec1u g\u00e2y t\u1eed vong \u01b0\u1edbc t\u00ednh 1\u20133 g. B\u1ed9t v\u00e0 dung d\u1ecbch \u0111\u1eadm \u0111\u1eb7c k\u00edch \u1ee9ng \u2013 tr\u00e1nh h\u00edt, nu\u1ed1t, ti\u1ebfp x\u00fac da, m\u1eaft; d\u00f9ng k\u00ednh, g\u0103ng tay, m\u1eb7t n\u1ea1.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> benzalkonium clorid, benzethonium clorid, cetylpyridinium clorid, CTAB.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Cetrimide<\/em> trong:
          \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
          \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
          \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
          \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
          \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Cetrimid (Cetrimide) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, ch\u1ea5t di\u1ec7n ho\u1ea1t cation Cetrimid (cetrimide, Cetavlon) l\u00e0 h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n \u2013 ch\u1ea5t di\u1ec7n ho\u1ea1t cation \u2013 d\u00f9ng trong m\u1ef9 ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n v\u00e0 ch\u1ea5t s\u00e1t khu\u1ea9n d\u00f9ng ngo\u00e0i. Th\u00f4ng tin nhanh T\u00ean kh\u00e1c Cetavlon, Cetab, Bromat, Cetraol, Lissolamine V, […]<\/p>","protected":false},"author":1,"featured_media":2239,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2240","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimid.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimid-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimid-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimid-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimid-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimid.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimid.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimid-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Cetrimid (Cetrimide) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, ch\u1ea5t di\u1ec7n ho\u1ea1t cation Cetrimid (cetrimide, Cetavlon) l\u00e0 h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n \u2013 ch\u1ea5t di\u1ec7n ho\u1ea1t cation \u2013 d\u00f9ng trong m\u1ef9 ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n v\u00e0 ch\u1ea5t s\u00e1t khu\u1ea9n d\u00f9ng ngo\u00e0i. Th\u00f4ng tin nhanh T\u00ean kh\u00e1c Cetavlon, Cetab, Bromat, Cetraol, Lissolamine V,…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2240","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2240"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2240\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2239"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2240"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2240"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2240"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}