{"id":2228,"date":"2026-09-27T10:56:05","date_gmt":"2026-09-27T03:56:05","guid":{"rendered":"https:\/\/cpc1.vn\/cellulose-vi-tinh-the-silic-hoa-smcc\/"},"modified":"2026-09-27T10:56:05","modified_gmt":"2026-09-27T03:56:05","slug":"cellulose-vi-tinh-the-silic-hoa-smcc","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/cellulose-vi-tinh-the-silic-hoa-smcc\/","title":{"rendered":"Cellulose vi tinh th\u1ec3 silic h\u00f3a (SMCC, ProSolv) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n n\u00e9n t\u1ed1t"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Cellulose vi tinh th\u1ec3 silic h\u00f3a (SMCC, ProSolv) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n n\u00e9n t\u1ed1t<\/h1>\n<p><strong>Cellulose vi tinh th\u1ec3 silic h\u00f3a<\/strong> (silicified microcrystalline cellulose, SMCC, ProSolv) l\u00e0 h\u1ed7n h\u1ee3p v\u1eadt l\u00fd g\u1eafn k\u1ebft ch\u1eb7t ch\u1ebd gi\u1eefa cellulose vi tinh th\u1ec3 (MCC) v\u00e0 <strong>2% silic dioxyd keo<\/strong>. SMCC \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 kh\u1eafc ph\u1ee5c nh\u01b0\u1ee3c \u0111i\u1ec3m c\u1ee7a MCC: m\u1ea5t kh\u1ea3 n\u0103ng ch\u1ecbu n\u00e9n sau khi x\u00e1t h\u1ea1t \u01b0\u1edbt.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>SMCC, ProSolv<\/td>\n<\/tr>\n<tr>\n<td>Th\u00e0nh ph\u1ea7n<\/td>\n<td>Cellulose vi tinh th\u1ec3 + 2% (kl\/kl) silic dioxyd keo \u2013 kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c h\u00f3a h\u1ecdc gi\u1eefa hai th\u00e0nh ph\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>T\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>T\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho vi\u00ean nang v\u00e0 vi\u00ean n\u00e9n, b\u1eb1ng d\u1eadp th\u1eb3ng ho\u1eb7c x\u00e1t h\u1ea1t \u01b0\u1edbt.<\/li>\n<li>So v\u1edbi MCC th\u00f4ng th\u01b0\u1eddng: <strong>\u0111\u1ed9 b\u1ec1n k\u00e9o c\u1ee7a vi\u00ean cao h\u01a1n<\/strong> v\u00e0 c\u1ea7n l\u1ef1c n\u00e9n th\u1ea5p h\u01a1n.<\/li>\n<li><strong>Gi\u1eef \u0111\u01b0\u1ee3c kh\u1ea3 n\u0103ng ch\u1ecbu n\u00e9n sau x\u00e1t h\u1ea1t \u01b0\u1edbt<\/strong> \u2013 vi\u00ean c\u1ee9ng h\u01a1n v\u00e0 c\u1ea7n nhi\u1ec1u n\u0103ng l\u01b0\u1ee3ng h\u01a1n \u0111\u1ec3 v\u1ee1.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>pH h\u1ed7n d\u1ecbch 10%: 5,0\u20137,5.<\/li>\n<li>T\u1ef7 tr\u1ecdng 1,58 g\/cm\u00b3; t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn kho\u1ea3ng 0,31 g\/cm\u00b3; t\u1ef7 tr\u1ecdng g\u00f5 kho\u1ea3ng 0,39 g\/cm\u00b3.<\/li>\n<li>\u0110\u1ed9 \u1ea9m th\u01b0\u1eddng d\u01b0\u1edbi 6%; c\u1ee1 h\u1ea1t \u0111i\u1ec3n h\u00ecnh 20\u2013200 \u00b5m t\u00f9y c\u1ea5p.<\/li>\n<li>Th\u00e0nh ph\u1ea7n MCC h\u00f3a than \u1edf 260\u2013270 \u00b0C.<\/li>\n<li>H\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc, acid lo\u00e3ng v\u00e0 ph\u1ea7n l\u1edbn dung m\u00f4i h\u1eefu c\u01a1; MCC h\u01a1i tan trong NaOH 5%.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>B\u1ec1n khi \u0111\u1ef1ng trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>Nh\u01b0 cellulose vi tinh th\u1ec3 v\u00e0 silic dioxyd keo (t\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh; silic dioxyd keo t\u01b0\u01a1ng k\u1ef5 v\u1edbi dietylstilbestrol).<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>\u0110\u1ed3ng s\u1ea5y h\u1ed7n d\u1ecbch ti\u1ec3u ph\u00e2n MCC v\u00e0 silic dioxyd keo \u0111\u1ec3 th\u00e0nh ph\u1ea9m ch\u1ee9a 2% silic dioxyd keo. Silic dioxyd keo g\u1eafn v\u1eadt l\u00fd tr\u00ean b\u1ec1 m\u1eb7t v\u00e0 b\u00ean trong ti\u1ec3u ph\u00e2n; c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ph\u1ed5 h\u1ecdc kh\u00f4ng ph\u00e1t hi\u1ec7n t\u01b0\u01a1ng t\u00e1c h\u00f3a h\u1ecdc.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>L\u00e0 h\u1ed7n h\u1ee3p v\u1eadt l\u00fd c\u1ee7a hai ch\u1ea5t \u0111\u1ec1u \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c. Thao t\u00e1c c\u00f3 th\u1ec3 t\u1ea1o b\u1ee5i \u2013 d\u00f9ng g\u0103ng tay, k\u00ednh, kh\u1ea9u trang. Gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m t\u1ea1i Anh (cellulose): 10 mg\/m\u00b3 b\u1ee5i to\u00e0n ph\u1ea7n, 4 mg\/m\u00b3 b\u1ee5i h\u00f4 h\u1ea5p (8 gi\u1edd), 20 mg\/m\u00b3 ng\u1eafn h\u1ea1n.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<p>C\u1ea3 hai th\u00e0nh ph\u1ea7n \u0111\u1ec1u c\u00f3 trong FDA Inactive Ingredients Guide, \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p trong thu\u1ed1c kh\u00f4ng ti\u00eam t\u1ea1i ch\u00e2u \u00c2u v\u00e0 M\u1ef9, v\u00e0 c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada; cellulose vi tinh th\u1ec3 \u0111\u01b0\u1ee3c x\u1ebfp GRAS.<\/p>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> cellulose vi tinh th\u1ec3, silic dioxyd keo.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Cellulose, Silicified Microcrystalline<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Cellulose vi tinh th\u1ec3 silic h\u00f3a (SMCC, ProSolv) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n n\u00e9n t\u1ed1t Cellulose vi tinh th\u1ec3 silic h\u00f3a (silicified microcrystalline cellulose, SMCC, ProSolv) l\u00e0 h\u1ed7n h\u1ee3p v\u1eadt l\u00fd g\u1eafn k\u1ebft ch\u1eb7t ch\u1ebd gi\u1eefa cellulose vi tinh th\u1ec3 (MCC) v\u00e0 2% silic dioxyd keo. SMCC \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 kh\u1eafc ph\u1ee5c nh\u01b0\u1ee3c \u0111i\u1ec3m c\u1ee7a [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2227,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2228","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellulose-vi-tinh-the-silic-hoa-smcc.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellulose-vi-tinh-the-silic-hoa-smcc-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellulose-vi-tinh-the-silic-hoa-smcc-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellulose-vi-tinh-the-silic-hoa-smcc-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellulose-vi-tinh-the-silic-hoa-smcc-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellulose-vi-tinh-the-silic-hoa-smcc.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellulose-vi-tinh-the-silic-hoa-smcc.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellulose-vi-tinh-the-silic-hoa-smcc-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Cellulose vi tinh th\u1ec3 silic h\u00f3a (SMCC, ProSolv) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n n\u00e9n t\u1ed1t Cellulose vi tinh th\u1ec3 silic h\u00f3a (silicified microcrystalline cellulose, SMCC, ProSolv) l\u00e0 h\u1ed7n h\u1ee3p v\u1eadt l\u00fd g\u1eafn k\u1ebft ch\u1eb7t ch\u1ebd gi\u1eefa cellulose vi tinh th\u1ec3 (MCC) v\u00e0 2% silic dioxyd keo. SMCC \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 kh\u1eafc ph\u1ee5c nh\u01b0\u1ee3c \u0111i\u1ec3m c\u1ee7a&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2228"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2228\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2227"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}