{"id":2204,"date":"2026-09-27T10:48:15","date_gmt":"2026-09-27T03:48:15","guid":{"rendered":"https:\/\/cpc1.vn\/tricalci-phosphat\/"},"modified":"2026-09-28T14:34:11","modified_gmt":"2026-09-28T07:34:11","slug":"tricalci-phosphat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/tricalci-phosphat\/","title":{"rendered":"Tricalci phosphat (TCP) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, d\u00ednh v\u00e0 ch\u1ed1ng v\u00f3n"},"content":{"rendered":"

Tricalci phosphat (TCP) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, d\u00ednh v\u00e0 ch\u1ed1ng v\u00f3n<\/h1>\n

Tricalci phosphat<\/strong> (tribasic calcium phosphate, TCP) kh\u00f4ng ph\u1ea3i m\u1ed9t h\u1ee3p ch\u1ea5t x\u00e1c \u0111\u1ecbnh m\u00e0 l\u00e0 h\u1ed7n h\u1ee3p c\u00e1c calci phosphat, th\u00e0nh ph\u1ea7n g\u1ea7n v\u1edbi hydroxyapatit Ca5<\/sub>(OH)(PO4<\/sub>)3<\/sub>. TCP \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n \u2013 d\u00ednh cho vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang (\u0111\u1eb7c bi\u1ec7t ch\u1ebf ph\u1ea9m vitamin \u2013 kho\u00e1ng ch\u1ea5t) v\u00e0 l\u00e0 ch\u1ea5t ch\u1ed1ng v\u00f3n quen thu\u1ed9c trong th\u1ef1c ph\u1ea9m.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nTertiary calcium phosphate, precipitated calcium phosphate, hydroxylapatite, tricalcium orthophosphate, E341; t\u00ean th\u01b0\u01a1ng m\u1ea1i: TRI-TAB, TRI-CAL WG, Tri-Cafos<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n12167-74-7 (calcium hydroxide phosphate); 7758-87-4 (tricalcium orthophosphate)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nCa3<\/sub>(PO4<\/sub>)2<\/sub> \u2013 310,20; Ca5<\/sub>(OH)(PO4<\/sub>)3<\/sub> \u2013 502,32<\/td>\n<\/tr>\n
Th\u00e0nh ph\u1ea7n theo d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nPh.Eur.: 35,0\u201340,0% calci. USP-NF: th\u00e0nh ph\u1ea7n g\u1ea7n \u0111\u00fang 10CaO\u00b73P2<\/sub>O5<\/sub>\u00b7H2<\/sub>O<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ch\u1ed1ng v\u00f3n, ch\u1ea5t \u0111\u1ec7m, ch\u1ea5t b\u1ed5 sung dinh d\u01b0\u1ee1ng, ch\u1ea5t \u0111i\u1ec1u h\u00f2a tr\u01a1n ch\u1ea3y, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng trong b\u00e0o ch\u1ebf<\/h2>\n
    \n
  • T\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n \u2013 d\u00ednh<\/strong> cho vi\u00ean nang, vi\u00ean n\u00e9n b\u1eb1ng d\u1eadp th\u1eb3ng ho\u1eb7c x\u00e1t h\u1ea1t \u01b0\u1edbt. C\u01a1 ch\u1ebf li\u00ean k\u1ebft ch\u00ednh khi n\u00e9n l\u00e0 bi\u1ebfn d\u1ea1ng d\u1ebbo<\/strong> (kh\u00e1c v\u1edbi dicalci phosphat v\u1ee1 gi\u00f2n).<\/li>\n
  • Nh\u01b0 dicalci phosphat, c\u00f4ng th\u1ee9c th\u01b0\u1eddng c\u1ea7n th\u00eam t\u00e1 d\u01b0\u1ee3c tr\u01a1n v\u00e0 t\u00e1 d\u01b0\u1ee3c r\u00e3; \u0111\u00f4i khi ch\u00ednh TCP \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c r\u00e3.<\/li>\n
  • D\u00f9ng nhi\u1ec1u nh\u1ea5t trong ch\u1ebf ph\u1ea9m vitamin \u2013 kho\u00e1ng ch\u1ea5t, v\u1eeba l\u00e0 t\u00e1 d\u01b0\u1ee3c v\u1eeba l\u00e0 ngu\u1ed3n calci v\u00e0 phospho. 1 g TCP cung c\u1ea5p kho\u1ea3ng 10,9 mmol calci v\u00e0 6,4 mmol phosphat (38% Ca, 17,3% P theo kh\u1ed1i l\u01b0\u1ee3ng) \u2013 t\u1ea3i calci v\u00e0 t\u1ef7 l\u1ec7 Ca\/P cao h\u01a1n dicalci phosphat.<\/li>\n
  • Th\u1ef1c ph\u1ea9m: ch\u1ea5t ch\u1ed1ng v\u00f3n cho b\u1ed9t.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng, kh\u00f4ng m\u00f9i, kh\u00f4ng v\u1ecb.<\/li>\n
    • pH h\u1ed7n d\u1ecbch 20%: kho\u1ea3ng 6,8; t\u1ef7 tr\u1ecdng th\u1ef1c 3,14 g\/cm\u00b3; n\u00f3ng ch\u1ea3y 1670 \u00b0C.<\/li>\n
    • D\u1ea1ng b\u1ed9t: t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,3\u20130,4 g\/cm\u00b3, h\u1ea1t 5\u201310 \u00b5m; d\u1ea1ng h\u1ea1t d\u1eadp th\u1eb3ng TRI-TAB: t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,80 g\/cm\u00b3, h\u1ea1t trung b\u00ecnh kho\u1ea3ng 350 \u00b5m, ch\u1ea3y 25 g\/s.<\/li>\n
    • Di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t ri\u00eang l\u1edbn (70\u201380 m\u00b2\/g) \u2013 l\u00fd do TCP ch\u1ed1ng v\u00f3n v\u00e0 h\u1ed7 tr\u1ee3 tr\u01a1n ch\u1ea3y t\u1ed1t.<\/li>\n
    • H\u01a1i h\u00fat \u1ea9m: \u0111\u1ed9 \u1ea9m c\u00e2n b\u1eb1ng kho\u1ea3ng 2% \u1edf 15\u201365% RH (25 \u00b0C); tr\u00ean kho\u1ea3ng 75% RH c\u00f3 th\u1ec3 h\u00fat th\u00eam m\u1ed9t \u00edt \u1ea9m; kh\u00f4ng t\u1ea1o hydrat x\u00e1c \u0111\u1ecbnh.<\/li>\n
    • Tan trong acid v\u00f4 c\u01a1 lo\u00e3ng; r\u1ea5t kh\u00f3 tan trong n\u01b0\u1edbc; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong acid acetic v\u00e0 alcol.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n v\u1ec1 m\u1eb7t h\u00f3a h\u1ecdc v\u00e0 kh\u00f4ng b\u1ecb \u0111\u00f3ng b\u00e1nh khi b\u1ea3o qu\u1ea3n. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • M\u1ecdi mu\u1ed1i calci \u0111\u1ec1u t\u01b0\u01a1ng k\u1ef5 v\u1edbi kh\u00e1ng sinh nh\u00f3m tetracyclin.<\/li>\n
      • T\u01b0\u01a1ng k\u1ef5 v\u1edbi tocopheryl acetat (nh\u01b0ng kh\u00f4ng v\u1edbi tocopheryl succinat) \u2013 l\u01b0u \u00fd khi ph\u1ed1i h\u1ee3p vitamin E trong vi\u00ean \u0111a vitamin.<\/li>\n
      • C\u00f3 th\u1ec3 t\u1ea1o phosphat kh\u00f3 tan v\u1edbi m\u1ed9t s\u1ed1 hormon.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        C\u00f3 trong t\u1ef1 nhi\u00ean d\u01b0\u1edbi d\u1ea1ng kho\u00e1ng hydroxylapatit, voelicherit, whitlockit. Th\u01b0\u01a1ng m\u1ea1i: x\u1eed l\u00fd qu\u1eb7ng phosphat b\u1eb1ng acid sulfuric r\u1ed3i k\u1ebft t\u1ee7a b\u1eb1ng calci hydroxyd; ho\u1eb7c cho calci hydroxyd (t\u1eeb \u0111\u00e1 v\u00f4i) ph\u1ea3n \u1ee9ng v\u1edbi acid phosphoric tinh khi\u1ebft; ho\u1eb7c t\u1eeb x\u01b0\u01a1ng \u0111\u1ed9ng v\u1eadt nung. Lo\u1ea1i h\u1ea1t th\u00f4 d\u1eadp th\u1eb3ng \u0111\u01b0\u1ee3c t\u1ea1o b\u1eb1ng n\u00e9n con l\u0103n ho\u1eb7c s\u1ea5y phun.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        \u1ede m\u1ee9c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c, TCP \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. Nu\u1ed1t ho\u1eb7c h\u00edt l\u01b0\u1ee3ng qu\u00e1 l\u1edbn c\u00f3 th\u1ec3 g\u00e2y l\u1eafng \u0111\u1ecdng tinh th\u1ec3 trong m\u00f4, g\u00e2y vi\u00eam t\u1ea1i ch\u1ed7; u\u1ed1ng l\u01b0\u1ee3ng r\u1ea5t l\u1edbn c\u00f3 th\u1ec3 g\u00e2y bu\u1ed3n n\u00f4n, n\u00f4n. D\u00f9ng k\u00ednh, g\u0103ng tay, l\u00e0m vi\u1ec7c n\u01a1i th\u00f4ng gi\u00f3; quy tr\u00ecnh nhi\u1ec1u b\u1ee5i c\u1ea7n m\u1eb7t n\u1ea1.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • FDA x\u1ebfp nh\u00f3m GRAS; c\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean nang, vi\u00ean n\u00e9n u\u1ed1ng).<\/li>\n
        • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> dicalci phosphat khan, dicalci phosphat dihydrat.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Calcium Phosphate, Tribasic<\/em> trong:
          \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
          \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
          \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
          \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
          \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Tricalci phosphat (TCP) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, d\u00ednh v\u00e0 ch\u1ed1ng v\u00f3n Tricalci phosphat (tribasic calcium phosphate, TCP) kh\u00f4ng ph\u1ea3i m\u1ed9t h\u1ee3p ch\u1ea5t x\u00e1c \u0111\u1ecbnh m\u00e0 l\u00e0 h\u1ed7n h\u1ee3p c\u00e1c calci phosphat, th\u00e0nh ph\u1ea7n g\u1ea7n v\u1edbi hydroxyapatit Ca5(OH)(PO4)3. TCP \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n \u2013 d\u00ednh cho vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang (\u0111\u1eb7c […]<\/p>","protected":false},"author":1,"featured_media":2203,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2204","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricalci-phosphat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricalci-phosphat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricalci-phosphat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricalci-phosphat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricalci-phosphat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricalci-phosphat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricalci-phosphat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricalci-phosphat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Tricalci phosphat (TCP) \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, d\u00ednh v\u00e0 ch\u1ed1ng v\u00f3n Tricalci phosphat (tribasic calcium phosphate, TCP) kh\u00f4ng ph\u1ea3i m\u1ed9t h\u1ee3p ch\u1ea5t x\u00e1c \u0111\u1ecbnh m\u00e0 l\u00e0 h\u1ed7n h\u1ee3p c\u00e1c calci phosphat, th\u00e0nh ph\u1ea7n g\u1ea7n v\u1edbi hydroxyapatit Ca5(OH)(PO4)3. TCP \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n \u2013 d\u00ednh cho vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang (\u0111\u1eb7c…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2204","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2204"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2204\/revisions"}],"predecessor-version":[{"id":2812,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2204\/revisions\/2812"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2203"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2204"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2204"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2204"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}