{"id":2190,"date":"2026-09-27T10:44:56","date_gmt":"2026-09-27T03:44:56","guid":{"rendered":"https:\/\/cpc1.vn\/butylat-hydroxytoluen-bht\/"},"modified":"2026-09-27T10:44:56","modified_gmt":"2026-09-27T03:44:56","slug":"butylat-hydroxytoluen-bht","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/butylat-hydroxytoluen-bht\/","title":{"rendered":"Butylat hydroxytoluen (BHT, E321) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1"},"content":{"rendered":"

Butylat hydroxytoluen (BHT, E321) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1<\/h1>\n

Butylat hydroxytoluen<\/strong> (BHT, E321) l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a g\u1ed1c phenol tan trong d\u1ea7u, d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m, ch\u1ee7 y\u1ebfu \u0111\u1ec3 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh \u00f4i h\u00f3a d\u1ea7u m\u1ee1 v\u00e0 b\u1ea3o v\u1ec7 c\u00e1c vitamin tan trong d\u1ea7u. So v\u1edbi BHA, BHT tan t\u1ed1t h\u01a1n trong d\u1ea7u m\u1ee1 th\u1ef1c ph\u1ea9m.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nBHT, E321, 2,6-di-tert-butyl-p-cresol, dibutylated hydroxytoluene; t\u00ean th\u01b0\u01a1ng m\u1ea1i: Embanox BHT, Ionol CP, Nipanox BHT, Tenox BHT, Topanol\u2026<\/td>\n<\/tr>\n
T\u00ean h\u00f3a h\u1ecdc<\/td>\n2,6-Di-tert-butyl-4-methylphenol<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n128-37-0<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC15<\/sub>H24<\/sub>O \u2013 220,35<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u0110\u1ed1i t\u01b0\u1ee3ng<\/th>\nN\u1ed3ng \u0111\u1ed9 BHT (%)<\/th>\n<\/tr>\n<\/thead>\n
\u03b2-Caroten<\/td>\n0,01<\/td>\n<\/tr>\n
D\u1ea7u th\u1ef1c v\u1eadt \u0103n \u0111\u01b0\u1ee3c<\/td>\n0,01<\/td>\n<\/tr>\n
Tinh d\u1ea7u, h\u01b0\u01a1ng li\u1ec7u<\/td>\n0,02\u20130,5<\/td>\n<\/tr>\n
D\u1ea7u v\u00e0 ch\u1ea5t b\u00e9o<\/td>\n0,02<\/td>\n<\/tr>\n
D\u1ea7u c\u00e1<\/td>\n0,01\u20130,1<\/td>\n<\/tr>\n
Thu\u1ed1c h\u00edt<\/td>\n0,01<\/td>\n<\/tr>\n
Thu\u1ed1c ti\u00eam b\u1eafp<\/td>\n0,03<\/td>\n<\/tr>\n
Thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch<\/td>\n0,0009\u20130,002<\/td>\n<\/tr>\n
Ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i<\/td>\n0,0075\u20130,1<\/td>\n<\/tr>\n
Vitamin A<\/td>\n10 mg cho m\u1ed7i tri\u1ec7u \u0111\u01a1n v\u1ecb<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

BHT c\u00f2n \u0111\u01b0\u1ee3c th\u00eam 0,5\u20131,0% v\u00e0o cao su t\u1ef1 nhi\u00ean ho\u1eb7c t\u1ed5ng h\u1ee3p \u0111\u1ec3 \u1ed5n \u0111\u1ecbnh m\u00e0u.<\/p>\n

M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
    \n
  • Ch\u1ea5t r\u1eafn k\u1ebft tinh ho\u1eb7c b\u1ed9t tr\u1eafng \u0111\u1ebfn v\u00e0ng nh\u1ea1t, m\u00f9i \u0111\u1eb7c tr\u01b0ng nh\u1eb9.<\/li>\n
  • Nhi\u1ec7t \u0111\u1ed9 n\u00f3ng ch\u1ea3y kho\u1ea3ng 70 \u00b0C; nhi\u1ec7t \u0111\u1ed9 s\u00f4i 265 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 127 \u00b0C (c\u1ed1c h\u1edf).<\/li>\n
  • T\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,48\u20130,60 g\/cm\u00b3; h\u1ec7 s\u1ed1 ph\u00e2n b\u1ed1 octanol:n\u01b0\u1edbc 4,17\u20135,80 (r\u1ea5t th\u00e2n d\u1ea7u).<\/li>\n
  • H\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc, glycerin, propylen glycol, dung d\u1ecbch ki\u1ec1m v\u00e0 acid v\u00f4 c\u01a1 lo\u00e3ng; d\u1ec5 tan trong aceton, ethanol 95%, ether, methanol, toluen, d\u1ea7u b\u00e9o v\u00e0 d\u1ea7u kho\u00e1ng.<\/li>\n<\/ul>\n

    \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

    \u00c1nh s\u00e1ng, \u0111\u1ed9 \u1ea9m v\u00e0 nhi\u1ec7t l\u00e0m \u0111\u1ed5i m\u00e0u, gi\u1ea3m ho\u1ea1t t\u00ednh. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t. Bao b\u00ec k\u00edn c\u00f3 th\u1ec3 n\u1ed5 do t\u0103ng \u00e1p khi g\u1eb7p nhi\u1ec7t \u0111\u1ed9 r\u1ea5t cao.<\/p>\n

    T\u01b0\u01a1ng k\u1ef5<\/h2>\n
      \n
    • Ph\u1ea3n \u1ee9ng \u0111\u1eb7c tr\u01b0ng c\u1ee7a phenol; t\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh (peroxid, permanganat) \u2013 ti\u1ebfp x\u00fac c\u00f3 th\u1ec3 t\u1ef1 b\u1ed1c ch\u00e1y.<\/li>\n
    • Mu\u1ed1i s\u1eaft g\u00e2y \u0111\u1ed5i m\u00e0u, m\u1ea5t ho\u1ea1t t\u00ednh.<\/li>\n
    • \u0110un v\u1edbi l\u01b0\u1ee3ng x\u00fac t\u00e1c acid g\u00e2y ph\u00e2n h\u1ee7y nhanh, gi\u1ea3i ph\u00f3ng kh\u00ed d\u1ec5 ch\u00e1y isobuten.<\/li>\n<\/ul>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cho p-cresol ph\u1ea3n \u1ee9ng v\u1edbi isobuten.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      BHT h\u1ea5p thu d\u1ec5 qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, chuy\u1ec3n h\u00f3a v\u00e0 th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u ch\u1ee7 y\u1ebfu d\u01b0\u1edbi d\u1ea1ng li\u00ean h\u1ee3p glucuronid c\u1ee7a c\u00e1c s\u1ea3n ph\u1ea9m oxy h\u00f3a. \u1ede m\u1ee9c d\u00f9ng ch\u1ed1ng oxy h\u00f3a, BHT \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng k\u00edch \u1ee9ng, kh\u00f4ng g\u00e2y m\u1eabn c\u1ea3m (c\u00f3 v\u00e0i b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng da ri\u00eang l\u1ebb). WHO \u0111\u1eb7t ADI t\u1ea1m th\u1eddi \u0111\u1ebfn 0,125 mg\/kg th\u1ec3 tr\u1ecdng. C\u00f3 b\u00e1o c\u00e1o u\u1ed1ng 4 g BHT g\u00e2y bu\u1ed3n n\u00f4n, n\u00f4n n\u1eb7ng nh\u01b0ng kh\u00f4ng t\u1eed vong. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft, da, h\u00f4 h\u1ea5p \u2013 thao t\u00e1c n\u01a1i th\u00f4ng gi\u00f3, d\u00f9ng g\u0103ng tay, k\u00ednh.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • FDA x\u1ebfp nh\u00f3m GRAS; c\u00f3 trong FDA Inactive Ingredients Guide (ti\u00eam b\u1eafp, ti\u00eam t\u0129nh m\u1ea1ch, x\u1ecbt m\u0169i, vi\u00ean nang, vi\u00ean n\u00e9n u\u1ed1ng, ch\u1ebf ph\u1ea9m tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o).<\/li>\n
      • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E321); c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> butylat hydroxyanisol (BHA), propyl gallat, alpha tocopherol.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Butylated Hydroxytoluene<\/em> trong:
        \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
        \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
        \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
        \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
        \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Butylat hydroxytoluen (BHT, E321) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1 Butylat hydroxytoluen (BHT, E321) l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a g\u1ed1c phenol tan trong d\u1ea7u, d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m, ch\u1ee7 y\u1ebfu \u0111\u1ec3 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh \u00f4i h\u00f3a d\u1ea7u m\u1ee1 v\u00e0 b\u1ea3o v\u1ec7 c\u00e1c vitamin tan trong […]<\/p>","protected":false},"author":1,"featured_media":2189,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2190","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxytoluen-bht.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxytoluen-bht-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxytoluen-bht-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxytoluen-bht-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxytoluen-bht-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxytoluen-bht.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxytoluen-bht.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxytoluen-bht-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Butylat hydroxytoluen (BHT, E321) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1 Butylat hydroxytoluen (BHT, E321) l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a g\u1ed1c phenol tan trong d\u1ea7u, d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m, ch\u1ee7 y\u1ebfu \u0111\u1ec3 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh \u00f4i h\u00f3a d\u1ea7u m\u1ee1 v\u00e0 b\u1ea3o v\u1ec7 c\u00e1c vitamin tan trong…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2190"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2190\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2189"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}