{"id":2188,"date":"2026-09-27T10:43:57","date_gmt":"2026-09-27T03:43:57","guid":{"rendered":"https:\/\/cpc1.vn\/butylat-hydroxyanisol-bha\/"},"modified":"2026-09-28T21:05:02","modified_gmt":"2026-09-28T14:05:02","slug":"butylat-hydroxyanisol-bha","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/butylat-hydroxyanisol-bha\/","title":{"rendered":"Butylat hydroxyanisol (BHA, E320) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a tan trong d\u1ea7u"},"content":{"rendered":"

Butylat hydroxyanisol (BHA, E320) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a tan trong d\u1ea7u<\/h1>\n

Butylat hydroxyanisol<\/strong> (BHA, E320) l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a g\u1ed1c phenol, tan trong d\u1ea7u, c\u00f3 th\u00eam m\u1ed9t s\u1ed1 t\u00ednh kh\u00e1ng khu\u1ea9n. BHA \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m \u0111\u1ec3 ch\u1ed1ng \u00f4i d\u1ea7u m\u1ee1 v\u00e0 b\u1ea3o v\u1ec7 vitamin tan trong d\u1ea7u.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nBHA, E320, tert-butyl-4-methoxyphenol; t\u00ean th\u01b0\u01a1ng m\u1ea1i: Nipanox BHA, Nipantiox 1-F, Tenox BHA<\/td>\n<\/tr>\n
T\u00ean h\u00f3a h\u1ecdc<\/td>\n2-tert-Butyl-4-methoxyphenol (Ph.Eur. cho ph\u00e9p t\u1ed1i \u0111a 10% \u0111\u1ed3ng ph\u00e2n 3-tert-butyl)<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n25013-16-5<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC11<\/sub>H16<\/sub>O2<\/sub> \u2013 180,25<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
\u0110\u1ed1i t\u01b0\u1ee3ng c\u1ea7n ch\u1ed1ng oxy h\u00f3a<\/th>\nN\u1ed3ng \u0111\u1ed9 BHA (%)<\/th>\n<\/tr>\n<\/thead>\n
\u03b2-Caroten<\/td>\n0,01<\/td>\n<\/tr>\n
Tinh d\u1ea7u, h\u01b0\u01a1ng li\u1ec7u<\/td>\n0,02\u20130,5<\/td>\n<\/tr>\n
Thu\u1ed1c ti\u00eam b\u1eafp<\/td>\n0,03<\/td>\n<\/tr>\n
Thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch<\/td>\n0,0002\u20130,0005<\/td>\n<\/tr>\n
D\u1ea7u v\u00e0 ch\u1ea5t b\u00e9o<\/td>\n0,02<\/td>\n<\/tr>\n
Ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i<\/td>\n0,005\u20130,02<\/td>\n<\/tr>\n
Vitamin A<\/td>\n10 mg cho m\u1ed7i tri\u1ec7u \u0111\u01a1n v\u1ecb<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • Th\u01b0\u1eddng ph\u1ed1i h\u1ee3p v\u1edbi ch\u1ea5t ch\u1ed1ng oxy h\u00f3a kh\u00e1c (\u0111\u1eb7c bi\u1ec7t BHT, alkyl gallat) v\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c\/hi\u1ec7p \u0111\u1ed3ng nh\u01b0 acid citric.<\/li>\n
  • Gi\u1edbi h\u1ea1n trong th\u1ef1c ph\u1ea9m (theo th\u00f4ng tin n\u0103m 2006): FDA \u2013 t\u1ed5ng ch\u1ea5t ch\u1ed1ng oxy h\u00f3a kh\u00f4ng qu\u00e1 0,02% (200 ppm) h\u00e0m l\u01b0\u1ee3ng d\u1ea7u m\u1ee1; USDA \u2013 0,01% cho m\u1ed9t ch\u1ea5t, 0,02% cho t\u1ed5ng c\u00e1c ch\u1ea5t trong m\u1ee1 \u0111\u1ed9ng v\u1eadt; Nh\u1eadt B\u1ea3n \u2013 \u0111\u1ebfn 1 g\/kg m\u1ee1 \u0111\u1ed9ng v\u1eadt.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, ho\u1eb7c kh\u1ed1i s\u00e1p tr\u1eafng ng\u00e0; m\u00f9i th\u01a1m \u0111\u1eb7c tr\u01b0ng nh\u1eb9.<\/li>\n
    • Nhi\u1ec7t \u0111\u1ed9 n\u00f3ng ch\u1ea3y kho\u1ea3ng 47 \u00b0C (\u0111\u1ed3ng ph\u00e2n 2-tert-butyl tinh khi\u1ebft); nhi\u1ec7t \u0111\u1ed9 s\u00f4i 264 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 130 \u00b0C.<\/li>\n
    • H\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc; tan trong methanol; d\u1ec5 tan trong ethanol \u2265 50%, propylen glycol, cloroform, ether, hexan, c\u00e1c lo\u1ea1i d\u1ea7u th\u1ef1c v\u1eadt (h\u1ea1t b\u00f4ng, l\u1ea1c, \u0111\u1eadu n\u00e0nh), glyceryl monooleat, m\u1ee1 l\u1ee3n v\u00e0 dung d\u1ecbch hydroxyd ki\u1ec1m.<\/li>\n
    • Ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n t\u01b0\u01a1ng t\u1ef1 paraben: m\u1ea1nh nh\u1ea5t tr\u00ean n\u1ea5m m\u1ed1c v\u00e0 vi khu\u1ea9n Gram d\u01b0\u01a1ng.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      \u00c1nh s\u00e1ng l\u00e0m \u0111\u1ed5i m\u00e0u v\u00e0 gi\u1ea3m ho\u1ea1t t\u00ednh. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      L\u00e0 phenol n\u00ean c\u00f3 c\u00e1c ph\u1ea3n \u1ee9ng \u0111\u1eb7c tr\u01b0ng c\u1ee7a phenol; t\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a v\u00e0 mu\u1ed1i s\u1eaft (III). V\u1ebft kim lo\u1ea1i v\u00e0 \u00e1nh s\u00e1ng g\u00e2y \u0111\u1ed5i m\u00e0u, gi\u1ea3m ho\u1ea1t t\u00ednh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cho p-methoxyphenol ph\u1ea3n \u1ee9ng v\u1edbi isobuten.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      BHA h\u1ea5p thu qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, chuy\u1ec3n h\u00f3a v\u00e0 th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u (d\u01b0\u1edbi 1% d\u1ea1ng nguy\u00ean v\u1eb9n trong 24 gi\u1edd). \u1ede m\u1ee9c d\u00f9ng l\u00e0m ch\u1ea5t ch\u1ed1ng oxy h\u00f3a, BHA \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng k\u00edch \u1ee9ng, kh\u00f4ng g\u00e2y m\u1eabn c\u1ea3m (c\u00f3 v\u00e0i b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng da ri\u00eang l\u1ebb). Nghi\u00ean c\u1ee9u cho g\u1eb7m nh\u1ea5m \u0103n BHA 1\u20132% kh\u1ea9u ph\u1ea7n g\u00e2y u \u1edf ti\u1ec1n d\u1ea1 d\u00e0y \u2013 c\u01a1 quan m\u00e0 ng\u01b0\u1eddi kh\u00f4ng c\u00f3; tr\u00ean c\u00e1c lo\u00e0i kh\u00f4ng c\u00f3 ti\u1ec1n d\u1ea1 d\u00e0y (ch\u00f3, kh\u1ec9, chu\u1ed9t lang) kh\u00f4ng th\u1ea5y t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i, n\u00ean c\u00e1c b\u1eb1ng ch\u1ee9ng kh\u00f4ng cho th\u1ea5y li\u00ean quan v\u1edbi m\u1ee9c ph\u01a1i nhi\u1ec5m th\u1ea5p \u1edf ng\u01b0\u1eddi. WHO \u0111\u1eb7t ADI c\u1ee7a BHA \u1edf m\u1ee9c 0,5 mg\/kg th\u1ec3 tr\u1ecdng. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft, da, h\u00f4 h\u1ea5p \u2013 thao t\u00e1c n\u01a1i th\u00f4ng gi\u00f3, d\u00f9ng g\u0103ng tay v\u00e0 k\u00ednh. Ch\u00e1y c\u00f3 th\u1ec3 sinh kh\u00f3i \u0111\u1ed9c.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • FDA x\u1ebfp nh\u00f3m GRAS; c\u00f3 trong FDA Inactive Ingredients Guide (ti\u00eam b\u1eafp, ti\u00eam t\u0129nh m\u1ea1ch, x\u1ecbt m\u0169i, vi\u00ean nang, vi\u00ean n\u00e9n u\u1ed1ng; ch\u1ebf ph\u1ea9m d\u01b0\u1edbi l\u01b0\u1ee1i, tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o).<\/li>\n
      • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E320); c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> butylat hydroxytoluen (BHT), propyl gallat.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Butylated Hydroxyanisole<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Butylat hydroxyanisol (BHA, E320) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a tan trong d\u1ea7u Butylat hydroxyanisol (BHA, E320) l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a g\u1ed1c phenol, tan trong d\u1ea7u, c\u00f3 th\u00eam m\u1ed9t s\u1ed1 t\u00ednh kh\u00e1ng khu\u1ea9n. BHA \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m \u0111\u1ec3 ch\u1ed1ng \u00f4i d\u1ea7u m\u1ee1 v\u00e0 b\u1ea3o v\u1ec7 vitamin […]<\/p>\n","protected":false},"author":1,"featured_media":2187,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2188","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxyanisol-bha.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxyanisol-bha-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxyanisol-bha-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxyanisol-bha-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxyanisol-bha-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxyanisol-bha.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxyanisol-bha.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/butylat-hydroxyanisol-bha-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Butylat hydroxyanisol (BHA, E320) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a tan trong d\u1ea7u Butylat hydroxyanisol (BHA, E320) l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a g\u1ed1c phenol, tan trong d\u1ea7u, c\u00f3 th\u00eam m\u1ed9t s\u1ed1 t\u00ednh kh\u00e1ng khu\u1ea9n. BHA \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m \u0111\u1ec3 ch\u1ed1ng \u00f4i d\u1ea7u m\u1ee1 v\u00e0 b\u1ea3o v\u1ec7 vitamin…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2188","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2188"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2188\/revisions"}],"predecessor-version":[{"id":3151,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2188\/revisions\/3151"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2187"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2188"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2188"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2188"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}