{"id":2186,"date":"2026-09-27T10:43:49","date_gmt":"2026-09-27T03:43:49","guid":{"rendered":"https:\/\/cpc1.vn\/bronopol\/"},"modified":"2026-09-27T10:43:49","modified_gmt":"2026-09-27T03:43:49","slug":"bronopol","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/bronopol\/","title":{"rendered":"Bronopol \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i v\u00e0 m\u1ef9 ph\u1ea9m"},"content":{"rendered":"

Bronopol \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i v\u00e0 m\u1ef9 ph\u1ea9m<\/h1>\n

Bronopol<\/strong> (2-bromo-2-nitro-1,3-propanediol) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n d\u00f9ng trong thu\u1ed1c d\u00f9ng ngo\u00e0i, m\u1ef9 ph\u1ea9m v\u00e0 \u0111\u1ed3 d\u00f9ng v\u1ec7 sinh. \u01afu \u0111i\u1ec3m n\u1ed5i b\u1eadt: t\u00e1c d\u1ee5ng t\u1ed1t tr\u00ean Pseudomonas aeruginosa<\/em> v\u00e0 \u01b0a dung m\u00f4i ph\u00e2n c\u1ef1c n\u00ean kh\u00f4ng b\u1ecb “th\u1ea5t tho\u00e1t” v\u00e0o pha d\u1ea7u c\u1ee7a nh\u0169 t\u01b0\u01a1ng nh\u01b0 m\u1ed9t s\u1ed1 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\n2-Bromo-2-nitro-1,3-propanediol, \u03b2-bromo-\u03b2-nitrotrimethyleneglycol, Myacide<\/td>\n<\/tr>\n
T\u00ean h\u00f3a h\u1ecdc<\/td>\n2-Bromo-2-nitropropan-1,3-diol<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n52-51-7<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC3<\/sub>H6<\/sub>BrNO4<\/sub> \u2013 200,00<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t s\u00e1t khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng trong b\u00e0o ch\u1ebf<\/h2>\n

Bronopol \u0111\u01b0\u1ee3c d\u00f9ng \u1edf n\u1ed3ng \u0111\u1ed9 0,01\u20130,1%<\/strong> (kl\/tt), th\u01b0\u1eddng nh\u1ea5t l\u00e0 0,02%<\/strong>, ri\u00eang l\u1ebb ho\u1eb7c ph\u1ed1i h\u1ee3p v\u1edbi ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c trong thu\u1ed1c d\u00f9ng ngo\u00e0i, m\u1ef9 ph\u1ea9m, \u0111\u1ed3 v\u1ec7 sinh c\u00e1 nh\u00e2n. \u1ede 0,02% bronopol hay \u0111\u01b0\u1ee3c ch\u1ecdn cho c\u00e1c c\u00f4ng th\u1ee9c “\u00edt g\u00e2y d\u1ecb \u1ee9ng”.<\/p>\n

\u01afu v\u00e0 nh\u01b0\u1ee3c \u0111i\u1ec3m<\/h2>\n\n\n\n\n\n\n\n\n
\u01afu \u0111i\u1ec3m<\/th>\nNh\u01b0\u1ee3c \u0111i\u1ec3m<\/th>\n<\/tr>\n<\/thead>\n
M\u1ea1nh tr\u00ean Pseudomonas aeruginosa<\/em>; \u00edt b\u1ecb vi sinh v\u1eadt \u0111\u1ec1 kh\u00e1ng<\/td>\nT\u00e1c d\u1ee5ng t\u01b0\u01a1ng \u0111\u1ed1i y\u1ebfu tr\u00ean n\u1ea5m men v\u00e0 n\u1ea5m m\u1ed1c<\/td>\n<\/tr>\n
\u01afa pha ph\u00e2n c\u1ef1c, kh\u00f4ng th\u1ea5t tho\u00e1t v\u00e0o pha d\u1ea7u nh\u0169 t\u01b0\u01a1ng<\/td>\nK\u00e9m b\u1ec1n \u1edf pH ki\u1ec1m<\/td>\n<\/tr>\n
H\u1ec7 s\u1ed1 n\u1ed3ng \u0111\u1ed9 th\u1ea5p (pha lo\u00e3ng \u00edt l\u00e0m m\u1ea5t hi\u1ec7u l\u1ef1c)<\/td>\nPh\u00e2n h\u1ee7y sinh formaldehyd v\u00e0 nitrit<\/td>\n<\/tr>\n
T\u01b0\u01a1ng h\u1ee3p v\u1edbi h\u1ea7u h\u1ebft ch\u1ea5t di\u1ec7n ho\u1ea1t, t\u00e1 d\u01b0\u1ee3c v\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
    \n
  • B\u1ed9t k\u1ebft tinh tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng; kh\u00f4ng m\u00f9i ho\u1eb7c m\u00f9i \u0111\u1eb7c tr\u01b0ng nh\u1eb9.<\/li>\n
  • pH dung d\u1ecbch 1%: 5,0\u20136,0, gi\u1ea3m d\u1ea7n khi b\u1ea3o qu\u1ea3n.<\/li>\n
  • Tan t\u1ed1t trong n\u01b0\u1edbc v\u00e0 c\u00e1c dung m\u00f4i ph\u00e2n c\u1ef1c.<\/li>\n<\/ul>\n

    \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

    D\u1ea1ng r\u1eafn b\u1ec1n \u0111\u1ebfn 2 n\u0103m \u1edf nhi\u1ec7t \u0111\u1ed9 v\u00e0 \u0111\u1ed9 \u1ea9m ph\u00f2ng m\u00e0 ho\u1ea1t t\u00ednh h\u1ea7u nh\u01b0 kh\u00f4ng \u0111\u1ed5i. Trong dung d\u1ecbch, bronopol b\u1ec1n h\u01a1n \u1edf m\u00f4i tr\u01b0\u1eddng acid. Th\u1eddi gian b\u00e1n h\u1ee7y c\u1ee7a dung d\u1ecbch \u0111\u1ec7m 0,03%:<\/p>\n\n\n\n\n\n\n
    Nhi\u1ec7t \u0111\u1ed9<\/th>\npH 4<\/th>\npH 6<\/th>\npH 8<\/th>\n<\/tr>\n<\/thead>\n
    25 \u00b0C<\/td>\n> 5 n\u0103m<\/td>\n> 5 n\u0103m<\/td>\nkho\u1ea3ng 4 th\u00e1ng<\/td>\n<\/tr>\n
    60 \u00b0C<\/td>\nkho\u1ea3ng 6 th\u00e1ng<\/td>\nkho\u1ea3ng 8 ng\u00e0y<\/td>\n< 1 ng\u00e0y<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    S\u1ea3n ph\u1ea9m ph\u00e2n h\u1ee7y g\u1ed3m formaldehyd v\u00e0 nitrit (formaldehyd sinh ra qu\u00e1 \u00edt \u0111\u1ec3 g\u00f3p ph\u1ea7n \u0111\u00e1ng k\u1ec3 v\u00e0o t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n). D\u01b0\u1edbi \u00e1nh s\u00e1ng, nh\u1ea5t l\u00e0 \u1edf pH ki\u1ec1m, dung d\u1ecbch ng\u1ea3 v\u00e0ng\/n\u00e2u nh\u01b0ng m\u1ee9c \u0111\u1ed5i m\u00e0u kh\u00f4ng t\u01b0\u01a1ng quan tr\u1ef1c ti\u1ebfp v\u1edbi m\u1ea5t ho\u1ea1t t\u00ednh. Nguy\u00ean li\u1ec7u b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00f4ng b\u1eb1ng nh\u00f4m<\/strong>, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

    T\u01b0\u01a1ng k\u1ef5<\/h2>\n
      \n
    • H\u1ee3p ch\u1ea5t sulfhydryl (thiol) l\u00e0m gi\u1ea3m m\u1ea1nh ho\u1ea1t t\u00ednh \u2013 cystein hydroclorid \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t trung h\u00f2a trong th\u1eed nghi\u1ec7m hi\u1ec7u qu\u1ea3 b\u1ea3o qu\u1ea3n (h\u1ed7n h\u1ee3p lecithin\/polysorbat kh\u00f4ng ph\u00f9 h\u1ee3p cho m\u1ee5c \u0111\u00edch n\u00e0y).<\/li>\n
    • Natri thiosulfat, natri metabisulfit; ch\u1ea5t di\u1ec7n ho\u1ea1t amin oxyd ho\u1eb7c protein th\u1ee7y ph\u00e2n.<\/li>\n
    • Nh\u00f4m \u2013 tr\u00e1nh d\u00f9ng bao b\u00ec nh\u00f4m cho s\u1ea3n ph\u1ea9m ch\u1ee9a bronopol.<\/li>\n<\/ul>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cho nitromethan ph\u1ea3n \u1ee9ng v\u1edbi paraformaldehyd trong m\u00f4i tr\u01b0\u1eddng ki\u1ec1m, sau \u0111\u00f3 brom h\u00f3a; k\u1ebft tinh v\u00e0 nghi\u1ec1n \u0111\u1ebfn \u0111\u1ed9 m\u1ecbn y\u00eau c\u1ea7u.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      \u0110\u1ebfn 0,1%, bronopol nh\u00ecn chung kh\u00f4ng k\u00edch \u1ee9ng, kh\u00f4ng g\u00e2y m\u1eabn c\u1ea3m, d\u00f9 c\u00f3 b\u00e1o c\u00e1o k\u00edch \u1ee9ng v\u00e0 qu\u00e1 m\u1eabn khi d\u00f9ng ngo\u00e0i. Nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng th\u1ea5y \u0111\u1ed9c t\u00ednh \u00e1nh s\u00e1ng, g\u00e2y u hay g\u00e2y \u0111\u1ed9t bi\u1ebfn. Do c\u00f3 th\u1ec3 gi\u1ea3i ph\u00f3ng nitrit, trong c\u00f4ng th\u1ee9c ch\u1ee9a amin c\u00f3 nguy c\u01a1 t\u1ea1o nitrosamin<\/strong> \u2013 c\u00f3 th\u1ec3 h\u1ea1n ch\u1ebf b\u1eb1ng c\u00e1ch gi\u1edbi h\u1ea1n bronopol \u1edf 0,01% v\u00e0 th\u00eam ch\u1ea5t ch\u1ed1ng oxy h\u00f3a nh\u01b0 alpha tocopherol 0,2% ho\u1eb7c BHT 0,05%. B\u1ed9t v\u00e0 dung d\u1ecbch \u0111\u1eadm \u0111\u1eb7c k\u00edch \u1ee9ng da, m\u1eaft; c\u00f3 th\u1ec3 c\u00f3 h\u1ea1i khi h\u00edt \u2013 d\u00f9ng k\u00ednh, g\u0103ng tay, kh\u1ea9u trang ch\u1ed1ng b\u1ee5i. Ch\u00e1y t\u1ea1o kh\u00f3i \u0111\u1ed9c.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • C\u00f3 trong thu\u1ed1c d\u00f9ng ngo\u00e0i \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i ch\u00e2u \u00c2u; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong BP.<\/li>\n<\/ul>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Bronopol<\/em> trong:
        \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
        \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
        \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
        \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
        \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Bronopol \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i v\u00e0 m\u1ef9 ph\u1ea9m Bronopol (2-bromo-2-nitro-1,3-propanediol) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n d\u00f9ng trong thu\u1ed1c d\u00f9ng ngo\u00e0i, m\u1ef9 ph\u1ea9m v\u00e0 \u0111\u1ed3 d\u00f9ng v\u1ec7 sinh. \u01afu \u0111i\u1ec3m n\u1ed5i b\u1eadt: t\u00e1c d\u1ee5ng t\u1ed1t tr\u00ean Pseudomonas aeruginosa v\u00e0 \u01b0a dung m\u00f4i ph\u00e2n c\u1ef1c n\u00ean kh\u00f4ng b\u1ecb “th\u1ea5t tho\u00e1t” v\u00e0o […]<\/p>","protected":false},"author":1,"featured_media":2185,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2186","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/bronopol.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/bronopol-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/bronopol-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/bronopol-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/bronopol-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/bronopol.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/bronopol.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/bronopol-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Bronopol \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i v\u00e0 m\u1ef9 ph\u1ea9m Bronopol (2-bromo-2-nitro-1,3-propanediol) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n d\u00f9ng trong thu\u1ed1c d\u00f9ng ngo\u00e0i, m\u1ef9 ph\u1ea9m v\u00e0 \u0111\u1ed3 d\u00f9ng v\u1ec7 sinh. \u01afu \u0111i\u1ec3m n\u1ed5i b\u1eadt: t\u00e1c d\u1ee5ng t\u1ed1t tr\u00ean Pseudomonas aeruginosa v\u00e0 \u01b0a dung m\u00f4i ph\u00e2n c\u1ef1c n\u00ean kh\u00f4ng b\u1ecb “th\u1ea5t tho\u00e1t” v\u00e0o…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2186"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2186\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2185"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}