{"id":2180,"date":"2026-09-27T10:41:43","date_gmt":"2026-09-27T03:41:43","guid":{"rendered":"https:\/\/cpc1.vn\/alcol-benzylic\/"},"modified":"2026-09-27T10:41:43","modified_gmt":"2026-09-27T03:41:43","slug":"alcol-benzylic","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/alcol-benzylic\/","title":{"rendered":"Alcol benzylic (Benzyl Alcohol) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, dung m\u00f4i"},"content":{"rendered":"

Alcol benzylic (Benzyl Alcohol) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, dung m\u00f4i<\/h1>\n

Alcol benzylic<\/strong> (benzyl alcohol, phenylmethanol) l\u00e0 ch\u1ea5t l\u1ecfng d\u1ea1ng d\u1ea7u c\u00f3 m\u00f9i th\u01a1m nh\u1eb9, \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/strong> trong thu\u1ed1c u\u1ed1ng, thu\u1ed1c ti\u00eam, m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m; \u1edf n\u1ed3ng \u0111\u1ed9 cao h\u01a1n c\u00f2n l\u00e0 ch\u1ea5t h\u00f2a tan v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng g\u00e2y t\u00ea t\u1ea1i ch\u1ed7 nh\u1eb9.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nBenzenemethanol, phenylcarbinol, phenylmethanol, \u03b1-hydroxytoluene, \u03b1-toluenol<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n100-51-6<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC7<\/sub>H8<\/sub>O \u2013 108,14<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t s\u00e1t khu\u1ea9n, dung m\u00f4i<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n\n\n\n\n\n\n\n\n
M\u1ee5c \u0111\u00edch<\/th>\nN\u1ed3ng \u0111\u1ed9 (% tt\/tt)<\/th>\n<\/tr>\n<\/thead>\n
Ch\u1ea5t b\u1ea3o qu\u1ea3n trong thu\u1ed1c u\u1ed1ng, thu\u1ed1c ti\u00eam<\/td>\n\u0111\u1ebfn 2,0<\/td>\n<\/tr>\n
Ch\u1ea5t b\u1ea3o qu\u1ea3n trong m\u1ef9 ph\u1ea9m<\/td>\n\u0111\u1ebfn 3,0<\/td>\n<\/tr>\n
Ch\u1ea5t h\u00f2a tan<\/td>\n\u2265 5<\/td>\n<\/tr>\n
Dung d\u1ecbch s\u00e1t khu\u1ea9n<\/td>\n10<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Dung d\u1ecbch 10% c\u00f3 t\u00e1c d\u1ee5ng g\u00e2y t\u00ea t\u1ea1i ch\u1ed7 nh\u1eb9, \u0111\u01b0\u1ee3c t\u1eadn d\u1ee5ng trong m\u1ed9t s\u1ed1 thu\u1ed1c ti\u00eam, thu\u1ed1c ho, dung d\u1ecbch nh\u1ecf m\u1eaft, thu\u1ed1c m\u1ee1 v\u00e0 kh\u00ed dung ngo\u00e0i da.<\/p>\n

Ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n<\/h2>\n
    \n
  • K\u00ecm khu\u1ea9n; t\u00e1c d\u1ee5ng tr\u00ean vi khu\u1ea9n Gram d\u01b0\u01a1ng, n\u1ea5m m\u1ed1c, n\u1ea5m men (MIC \u0111i\u1ec3n h\u00ecnh 3\u20135 mg\/mL); y\u1ebfu h\u01a1n tr\u00ean Gram \u00e2m; kh\u00f4ng t\u00e1c d\u1ee5ng tr\u00ean b\u00e0o t\u1eed (nh\u01b0ng t\u0103ng khi gia nhi\u1ec7t).<\/li>\n
  • T\u1ed1i \u01b0u \u1edf pH d\u01b0\u1edbi 5; h\u1ea7u nh\u01b0 kh\u00f4ng t\u00e1c d\u1ee5ng tr\u00ean pH 8.<\/li>\n
  • Ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion h\u00f3a (nh\u01b0 polysorbat 80) l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng, nh\u01b0ng m\u1ee9c gi\u1ea3m \u00edt h\u01a1n so v\u1edbi paraben ho\u1eb7c h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t l\u1ecfng d\u1ea1ng d\u1ea7u trong, kh\u00f4ng m\u00e0u, m\u00f9i th\u01a1m nh\u1eb9, v\u1ecb cay n\u00f3ng; dung d\u1ecbch n\u01b0\u1edbc trung t\u00ednh.<\/li>\n
    • Nhi\u1ec7t \u0111\u1ed9 s\u00f4i 204,7 \u00b0C; \u0111i\u1ec3m \u0111\u00f4ng \u0111\u1eb7c \u221215 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y kho\u1ea3ng 101 \u00b0C (c\u1ed1c k\u00edn); d\u1ec5 ch\u00e1y.<\/li>\n
    • Tan 1\/25 trong n\u01b0\u1edbc (25 \u00b0C), 1\/2,5 trong ethanol 50%; tr\u1ed9n l\u1eabn v\u1edbi ethanol, ether, cloroform, d\u1ea7u b\u00e9o v\u00e0 tinh d\u1ea7u.<\/li>\n
    • \u0110\u1ed9 nh\u1edbt kho\u1ea3ng 6 mPa\u00b7s \u1edf 20 \u00b0C.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ecb oxy h\u00f3a ch\u1eadm trong kh\u00f4ng kh\u00ed th\u00e0nh benzaldehyd v\u00e0 acid benzoic. Dung d\u1ecbch n\u01b0\u1edbc ti\u1ec7t khu\u1ea9n \u0111\u01b0\u1ee3c b\u1eb1ng l\u1ecdc ho\u1eb7c h\u1ea5p (c\u00f3 th\u1ec3 sinh benzaldehyd khi h\u1ea5p). N\u00ean \u0111\u1ef1ng trong bao b\u00ec kim lo\u1ea1i ho\u1eb7c th\u1ee7y tinh; tr\u00e1nh bao b\u00ec nh\u1ef1a<\/strong>, tr\u1eeb polypropylen ho\u1eb7c bao b\u00ec ph\u1ee7 polyme fluor (Teflon). B\u1ea3o qu\u1ea3n k\u00edn kh\u00ed, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • Ch\u1ea5t oxy h\u00f3a v\u00e0 acid m\u1ea1nh; c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y t\u1ef1 oxy h\u00f3a ch\u1ea5t b\u00e9o.<\/li>\n
      • T\u01b0\u01a1ng k\u1ef5 v\u1edbi methylcellulose.<\/li>\n
      • B\u1ecb h\u1ea5p th\u1ee5 ch\u1eadm v\u00e0o n\u00fat cao su t\u1ef1 nhi\u00ean, neopren, butyl (c\u00f3 th\u1ec3 ph\u1ee7 polyme fluor \u0111\u1ec3 c\u1ea3i thi\u1ec7n).<\/li>\n
      • Dung d\u1ecbch 2% trong chai polyethylen c\u00f3 th\u1ec3 m\u1ea5t \u0111\u1ebfn 15% alcol benzylic sau 13 tu\u1ea7n; m\u1ea5t v\u00e0o PVC v\u00e0 polypropylen th\u01b0\u1eddng kh\u00f4ng \u0111\u00e1ng k\u1ec3. C\u00f3 th\u1ec3 l\u00e0m h\u1ecfng b\u01a1m ti\u00eam polystyren.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Ch\u01b0ng c\u1ea5t benzyl clorid v\u1edbi kali ho\u1eb7c natri carbonat; ho\u1eb7c t\u1eeb benzaldehyd v\u00e0 kali hydroxyd (ph\u1ea3n \u1ee9ng Cannizzaro).<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        Alcol benzylic chuy\u1ec3n h\u00f3a th\u00e0nh acid benzoic, r\u1ed3i li\u00ean h\u1ee3p glycin \u1edf gan t\u1ea1o acid hippuric th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u. \u1ede n\u1ed3ng \u0111\u1ed9 d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n th\u01b0\u1eddng kh\u00f4ng g\u00e2y t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i. Tuy nhi\u00ean \u0111\u00e3 ghi nh\u1eadn:<\/p>\n

          \n
        • H\u1ed9i ch\u1ee9ng \u0111\u1ed9c g\u00e2y t\u1eed vong \u1edf tr\u1ebb s\u01a1 sinh nh\u1eb9 c\u00e2n<\/strong> (nhi\u1ec5m toan chuy\u1ec3n h\u00f3a, \u1ee9c ch\u1ebf h\u00f4 h\u1ea5p) khi d\u00f9ng dung d\u1ecbch ch\u1ee9a alcol benzylic \u0111\u1ec3 b\u01a1m r\u1eeda catheter r\u1ed1n. FDA khuy\u1ebfn c\u00e1o kh\u00f4ng d\u00f9ng alcol benzylic trong dung d\u1ecbch b\u01a1m r\u1eeda n\u00e0y v\u00e0 tr\u00e1nh thu\u1ed1c c\u00f3 ch\u1ea5t b\u1ea3o qu\u1ea3n cho tr\u1ebb s\u01a1 sinh.<\/li>\n
        • \u0110\u1ed9c t\u00ednh khi ti\u00eam t\u0129nh m\u1ea1ch, \u0111\u1ed9c th\u1ea7n kinh khi d\u00f9ng trong ch\u1ebf ph\u1ea9m ti\u00eam t\u1ee7y s\u1ed1ng, v\u00e0 hi\u1ebfm g\u1eb7p qu\u00e1 m\u1eabn.<\/li>\n<\/ul>\n

          WHO \u01b0\u1edbc t\u00ednh ADI c\u1ee7a g\u1ed1c benzyl\/benzoic \u0111\u1ebfn 5 mg\/kg th\u1ec3 tr\u1ecdng. Ch\u1ea5t l\u1ecfng v\u00e0 h\u01a1i k\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c \u2013 d\u00f9ng k\u00ednh, g\u0103ng tay, qu\u1ea7n \u00e1o b\u1ea3o h\u1ed9, l\u00e0m vi\u1ec7c n\u01a1i th\u00f4ng gi\u00f3; alcol benzylic d\u1ec5 ch\u00e1y.<\/p>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • C\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c ti\u00eam nha khoa, vi\u00ean nang, dung d\u1ecbch, vi\u00ean n\u00e9n u\u1ed1ng, ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o).<\/li>\n
          • C\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
          • C\u00f3 chuy\u00ean lu\u1eadn trong JP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan:<\/strong> acid benzoic, benzyl benzoat, phenylethyl alcol.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Benzyl Alcohol<\/em> trong:
            \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
            \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
            \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
            \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
            \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Alcol benzylic (Benzyl Alcohol) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, dung m\u00f4i Alcol benzylic (benzyl alcohol, phenylmethanol) l\u00e0 ch\u1ea5t l\u1ecfng d\u1ea1ng d\u1ea7u c\u00f3 m\u00f9i th\u01a1m nh\u1eb9, \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n trong thu\u1ed1c u\u1ed1ng, thu\u1ed1c ti\u00eam, m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m; \u1edf n\u1ed3ng \u0111\u1ed9 cao h\u01a1n c\u00f2n l\u00e0 ch\u1ea5t h\u00f2a tan v\u00e0 c\u00f3 […]<\/p>","protected":false},"author":1,"featured_media":2179,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2180","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-benzylic.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-benzylic-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-benzylic-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-benzylic-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-benzylic-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-benzylic.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-benzylic.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-benzylic-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Alcol benzylic (Benzyl Alcohol) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, dung m\u00f4i Alcol benzylic (benzyl alcohol, phenylmethanol) l\u00e0 ch\u1ea5t l\u1ecfng d\u1ea1ng d\u1ea7u c\u00f3 m\u00f9i th\u01a1m nh\u1eb9, \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n trong thu\u1ed1c u\u1ed1ng, thu\u1ed1c ti\u00eam, m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m; \u1edf n\u1ed3ng \u0111\u1ed9 cao h\u01a1n c\u00f2n l\u00e0 ch\u1ea5t h\u00f2a tan v\u00e0 c\u00f3…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2180","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2180"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2180\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2179"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2180"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2180"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}