{"id":2174,"date":"2026-09-27T10:40:21","date_gmt":"2026-09-27T03:40:21","guid":{"rendered":"https:\/\/cpc1.vn\/benzalkonium-clorid\/"},"modified":"2026-09-27T10:40:21","modified_gmt":"2026-09-27T03:40:21","slug":"benzalkonium-clorid","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/benzalkonium-clorid\/","title":{"rendered":"Benzalkonium clorid (BKC) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n thu\u1ed1c nh\u1ecf m\u1eaft, nh\u1ecf m\u0169i"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Benzalkonium clorid (BKC) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n thu\u1ed1c nh\u1ecf m\u1eaft, nh\u1ecf m\u0169i<\/h1>\n<p><strong>Benzalkonium clorid<\/strong> (BKC) l\u00e0 h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n \u2013 ch\u1ea5t di\u1ec7n ho\u1ea1t cation \u2013 v\u00e0 l\u00e0 m\u1ed9t trong nh\u1eefng <strong>ch\u1ea5t b\u1ea3o qu\u1ea3n \u0111\u01b0\u1ee3c d\u00f9ng nhi\u1ec1u nh\u1ea5t trong thu\u1ed1c nh\u1ecf m\u1eaft<\/strong>. BKC c\u00f2n d\u00f9ng trong thu\u1ed1c nh\u1ecf m\u0169i, nh\u1ecf tai, thu\u1ed1c ti\u00eam th\u1ec3 t\u00edch nh\u1ecf v\u00e0 m\u1ef9 ph\u1ea9m.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>BKC, alkylbenzyldimethylammonium chloride, alkyl dimethyl benzyl ammonium chloride; t\u00ean th\u01b0\u01a1ng m\u1ea1i: Hyamine 3500, Zephiran, Pentonium<\/td>\n<\/tr>\n<tr>\n<td>T\u00ean h\u00f3a h\u1ecdc<\/td>\n<td>Alkyldimethyl(phenylmethyl)ammonium clorid<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>8001-54-5<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c<\/td>\n<td>[C<sub>6<\/sub>H<sub>5<\/sub>CH<sub>2<\/sub>N(CH<sub>3<\/sub>)<sub>2<\/sub>R]Cl \u2013 R l\u00e0 h\u1ed7n h\u1ee3p alkyl t\u1eeb n-C<sub>8<\/sub>H<sub>17<\/sub> \u0111\u1ebfn n-C<sub>18<\/sub>H<sub>37<\/sub>, ch\u1ee7 y\u1ebfu C12, C14, C16; KLPT trung b\u00ecnh kho\u1ea3ng 360<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t s\u00e1t khu\u1ea9n, ch\u1ea5t h\u00f2a tan, ch\u1ea5t g\u00e2y th\u1ea5m<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u1ee8ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9<\/h2>\n<table>\n<thead>\n<tr>\n<th>D\u1ea1ng b\u00e0o ch\u1ebf<\/th>\n<th>N\u1ed3ng \u0111\u1ed9 BKC (% kl\/tt)<\/th>\n<th>Ghi ch\u00fa<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Thu\u1ed1c nh\u1ecf m\u1eaft<\/td>\n<td>0,01\u20130,02<\/td>\n<td>Th\u01b0\u1eddng ph\u1ed1i h\u1ee3p dinatri edetat 0,1% \u0111\u1ec3 t\u0103ng t\u00e1c d\u1ee5ng tr\u00ean <em>Pseudomonas<\/em><\/td>\n<\/tr>\n<tr>\n<td>Thu\u1ed1c nh\u1ecf m\u0169i, nh\u1ecf tai<\/td>\n<td>0,002\u20130,02<\/td>\n<td>\u0110\u00f4i khi ph\u1ed1i h\u1ee3p thimerosal 0,002\u20130,005%<\/td>\n<\/tr>\n<tr>\n<td>Thu\u1ed1c ti\u00eam th\u1ec3 t\u00edch nh\u1ecf<\/td>\n<td>0,01<\/td>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>BKC c\u00f2n l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n trong m\u1ef9 ph\u1ea9m, d\u00f9ng trong kh\u0103n s\u00e1t khu\u1ea9n (\u00edt g\u00e2y x\u00f3t h\u01a1n c\u1ed3n isopropylic v\u00e0 n\u01b0\u1edbc oxy gi\u00e0), v\u00e0 t\u1eebng \u0111\u01b0\u1ee3c ghi nh\u1eadn l\u00e0m t\u0103ng th\u1ea5m qua da c\u1ee7a m\u1ed9t s\u1ed1 ho\u1ea1t ch\u1ea5t.<\/p>\n<h2>Ph\u1ed5 kh\u00e1ng khu\u1ea9n<\/h2>\n<ul>\n<li>T\u00e1c d\u1ee5ng tr\u00ean nhi\u1ec1u vi khu\u1ea9n, n\u1ea5m men v\u00e0 n\u1ea5m; m\u1ea1nh tr\u00ean vi khu\u1ea9n Gram d\u01b0\u01a1ng h\u01a1n Gram \u00e2m; r\u1ea5t y\u1ebfu tr\u00ean b\u00e0o t\u1eed v\u00e0 vi khu\u1ea9n kh\u00e1ng acid.<\/li>\n<li>Kh\u00f4ng hi\u1ec7u qu\u1ea3 v\u1edbi m\u1ed9t s\u1ed1 ch\u1ee7ng <em>Pseudomonas aeruginosa<\/em>, <em>Mycobacterium tuberculosis<\/em>, <em>Trichophyton<\/em>. Ph\u1ed1i h\u1ee3p dinatri edetat (0,01\u20130,1%), alcol benzylic, phenylethanol ho\u1eb7c phenylpropanol l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng tr\u00ean <em>P. aeruginosa<\/em>.<\/li>\n<li>Ho\u1ea1t t\u00ednh ph\u1ee5 thu\u1ed9c th\u00e0nh ph\u1ea7n \u0111\u1ed3ng \u0111\u1eb3ng alkyl; c\u00f3 t\u00e1c d\u1ee5ng trong kho\u1ea3ng pH 4\u201310, t\u0103ng khi pH t\u0103ng.<\/li>\n<li>\u0110\u1ec7m citrat v\u00e0 phosphat (nh\u01b0ng kh\u00f4ng ph\u1ea3i borat) c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng tr\u00ean <em>Pseudomonas<\/em>.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t v\u00f4 \u0111\u1ecbnh h\u00ecnh tr\u1eafng \u0111\u1ebfn tr\u1eafng ng\u00e0, gel \u0111\u1eb7c ho\u1eb7c m\u1ea3nh d\u1ea1ng keo; h\u00fat \u1ea9m; s\u1edd tr\u01a1n nh\u01b0 x\u00e0 ph\u00f2ng; m\u00f9i th\u01a1m nh\u1eb9, v\u1ecb r\u1ea5t \u0111\u1eafng.<\/li>\n<li>pH dung d\u1ecbch 10%: 5\u20138; nhi\u1ec7t \u0111\u1ed9 n\u00f3ng ch\u1ea3y kho\u1ea3ng 40 \u00b0C; t\u1ef7 tr\u1ecdng 0,98 g\/cm\u00b3.<\/li>\n<li>R\u1ea5t d\u1ec5 tan trong n\u01b0\u1edbc v\u00e0 ethanol.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>BKC h\u00fat \u1ea9m, c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi \u00e1nh s\u00e1ng, kh\u00f4ng kh\u00ed v\u00e0 kim lo\u1ea1i. Dung d\u1ecbch b\u1ec1n trong kho\u1ea3ng pH v\u00e0 nhi\u1ec7t \u0111\u1ed9 r\u1ed9ng, c\u00f3 th\u1ec3 h\u1ea5p ti\u1ec7t khu\u1ea9n m\u00e0 kh\u00f4ng gi\u1ea3m hi\u1ec7u l\u1ef1c, b\u1ea3o qu\u1ea3n l\u00e2u \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng. Dung d\u1ecbch lo\u00e3ng \u0111\u1ef1ng trong bao b\u00ec PVC ho\u1eb7c x\u1ed1p polyurethan c\u00f3 th\u1ec3 m\u1ea5t ho\u1ea1t t\u00ednh. Nguy\u00ean li\u1ec7u c\u1ea7n bao b\u00ec k\u00edn kh\u00ed, tr\u00e1nh \u00e1nh s\u00e1ng v\u00e0 ti\u1ebfp x\u00fac kim lo\u1ea1i, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>T\u01b0\u01a1ng k\u1ef5 v\u1edbi: nh\u00f4m, ch\u1ea5t di\u1ec7n ho\u1ea1t anion v\u00e0 x\u00e0 ph\u00f2ng, citrat, b\u00f4ng, fluorescein, hydrogen peroxyd, hypromellose, iodid, kaolin, lanolin, nitrat, ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion h\u00f3a n\u1ed3ng \u0111\u1ed9 cao, permanganat, protein, salicylat, mu\u1ed1i b\u1ea1c, sulfonamid, tartrat, k\u1ebdm oxyd, k\u1ebdm sulfat, m\u1ed9t s\u1ed1 lo\u1ea1i cao su v\u00e0 nh\u1ef1a. BKC b\u1ecb h\u1ea5p ph\u1ee5 l\u00ean m\u00e0ng l\u1ecdc, nh\u1ea5t l\u00e0 m\u00e0ng k\u1ef5 n\u01b0\u1edbc ho\u1eb7c mang \u0111i\u1ec7n \u00e2m \u2013 c\u1ea7n l\u01b0u \u00fd khi l\u1ecdc v\u00f4 khu\u1ea9n.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Cho dung d\u1ecbch N-alkyl-N-methylbenzylamin ph\u1ea3n \u1ee9ng v\u1edbi methyl clorid trong dung m\u00f4i h\u1eefu c\u01a1 th\u00edch h\u1ee3p \u0111\u1ec3 h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n k\u1ebft t\u1ee7a khi h\u00ecnh th\u00e0nh.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>\u1ede n\u1ed3ng \u0111\u1ed9 pha lo\u00e3ng th\u00f4ng th\u01b0\u1eddng, BKC dung n\u1ea1p t\u1ed1t tr\u00ean da v\u00e0 ni\u00eam m\u1ea1c. Tuy v\u1eady c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c tai khi d\u00f9ng \u1edf tai, k\u00edch \u1ee9ng v\u00e0 qu\u00e1 m\u1eabn khi ti\u1ebfp x\u00fac da k\u00e9o d\u00e0i, co th\u1eaft ph\u1ebf qu\u1ea3n \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi hen khi d\u00f9ng trong dung d\u1ecbch kh\u00ed dung.<\/li>\n<li>Nhi\u1ec1u thu\u1ed1c nh\u1ecf m\u1eaft d\u00f9ng BKC 0,01%; <strong>kh\u00f4ng d\u00f9ng<\/strong> cho dung d\u1ecbch ng\u00e2m r\u1eeda k\u00ednh \u00e1p tr\u00f2ng m\u1ec1m \u01b0a n\u01b0\u1edbc v\u00ec BKC g\u1eafn v\u00e0o k\u00ednh v\u00e0 g\u00e2y \u0111\u1ed9c cho m\u1eaft. Dung d\u1ecbch tr\u00ean 0,03% v\u00e0o m\u1eaft c\u1ea7n \u0111\u01b0\u1ee3c x\u1eed tr\u00ed y t\u1ebf ngay.<\/li>\n<li>Dung d\u1ecbch \u0111\u1eadm \u0111\u1eb7c (> 0,1%) g\u00e2y k\u00edch \u1ee9ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a; li\u1ec1u u\u1ed1ng g\u00e2y t\u1eed vong \u1edf ng\u01b0\u1eddi \u01b0\u1edbc t\u00ednh 1\u20133 g.<\/li>\n<li>K\u00edch \u1ee9ng da, m\u1eaft; dung d\u1ecbch \u0111\u1eadm \u0111\u1eb7c \u0111\u1ed5 l\u00ean da c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng \u0103n m\u00f2n s\u00e2u \u2013 r\u1eeda ngay b\u1eb1ng nhi\u1ec1u n\u01b0\u1edbc r\u1ed3i x\u00e0 ph\u00f2ng. D\u00f9ng g\u0103ng tay, k\u00ednh v\u00e0 qu\u1ea7n \u00e1o b\u1ea3o h\u1ed9.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c h\u00edt, ti\u00eam b\u1eafp, nh\u1ecf m\u0169i, nh\u1ecf m\u1eaft, nh\u1ecf tai, d\u00f9ng ngo\u00e0i).<\/li>\n<li>C\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong JP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> benzethonium clorid, cetrimid, cetylpyridinium clorid.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Benzalkonium Chloride<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Benzalkonium clorid (BKC) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n thu\u1ed1c nh\u1ecf m\u1eaft, nh\u1ecf m\u0169i Benzalkonium clorid (BKC) l\u00e0 h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n \u2013 ch\u1ea5t di\u1ec7n ho\u1ea1t cation \u2013 v\u00e0 l\u00e0 m\u1ed9t trong nh\u1eefng ch\u1ea5t b\u1ea3o qu\u1ea3n \u0111\u01b0\u1ee3c d\u00f9ng nhi\u1ec1u nh\u1ea5t trong thu\u1ed1c nh\u1ecf m\u1eaft. BKC c\u00f2n d\u00f9ng trong thu\u1ed1c nh\u1ecf m\u0169i, nh\u1ecf tai, thu\u1ed1c ti\u00eam th\u1ec3 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2173,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2174","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/benzalkonium-clorid.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/benzalkonium-clorid-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/benzalkonium-clorid-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/benzalkonium-clorid-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/benzalkonium-clorid-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/benzalkonium-clorid.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/benzalkonium-clorid.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/benzalkonium-clorid-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Benzalkonium clorid (BKC) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n thu\u1ed1c nh\u1ecf m\u1eaft, nh\u1ecf m\u0169i Benzalkonium clorid (BKC) l\u00e0 h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n \u2013 ch\u1ea5t di\u1ec7n ho\u1ea1t cation \u2013 v\u00e0 l\u00e0 m\u1ed9t trong nh\u1eefng ch\u1ea5t b\u1ea3o qu\u1ea3n \u0111\u01b0\u1ee3c d\u00f9ng nhi\u1ec1u nh\u1ea5t trong thu\u1ed1c nh\u1ecf m\u1eaft. BKC c\u00f2n d\u00f9ng trong thu\u1ed1c nh\u1ecf m\u0169i, nh\u1ecf tai, thu\u1ed1c ti\u00eam th\u1ec3&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2174"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2174\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2173"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}