{"id":2168,"date":"2026-09-27T10:39:01","date_gmt":"2026-09-27T03:39:01","guid":{"rendered":"https:\/\/cpc1.vn\/aspartam\/"},"modified":"2026-09-28T14:34:22","modified_gmt":"2026-09-28T07:34:22","slug":"aspartam","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/aspartam\/","title":{"rendered":"Aspartam (Aspartame, E951) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Aspartam (Aspartame, E951) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao<\/h1>\n<p><strong>Aspartam<\/strong> (aspartame, APM, E951) l\u00e0 dipeptid methyl ester c\u1ee7a acid L-aspartic v\u00e0 L-phenylalanin, ng\u1ecdt g\u1ea5p kho\u1ea3ng 180\u2013200 l\u1ea7n saccarose. Aspartam \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o ng\u1ecdt trong vi\u00ean n\u00e9n, thu\u1ed1c b\u1ed9t pha, ch\u1ebf ph\u1ea9m vitamin, \u0111\u1ed3 u\u1ed1ng v\u00e0 th\u1ef1c ph\u1ea9m.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>APM, E951, methyl N-\u03b1-L-aspartyl-L-phenylalaninate; t\u00ean th\u01b0\u01a1ng m\u1ea1i: NutraSweet, Equal, Canderel<\/td>\n<\/tr>\n<tr>\n<td>T\u00ean h\u00f3a h\u1ecdc<\/td>\n<td>N-\u03b1-L-Aspartyl-L-phenylalanin 1-methyl ester<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>22839-47-0<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>14<\/sub>H<sub>18<\/sub>N<sub>2<\/sub>O<sub>5<\/sub> \u2013 294,31<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Sweeteners<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u1ee8ng d\u1ee5ng trong b\u00e0o ch\u1ebf<\/h2>\n<ul>\n<li>Ch\u1ea5t t\u1ea1o ng\u1ecdt cho vi\u00ean n\u00e9n (k\u1ec3 c\u1ea3 vi\u00ean nhai, vi\u00ean s\u1ee7i), thu\u1ed1c b\u1ed9t v\u00e0 c\u1ed1m pha, ch\u1ebf ph\u1ea9m vitamin, mi\u1ebfng d\u00e1n ni\u00eam m\u1ea1c m\u00e1.<\/li>\n<li>T\u0103ng c\u01b0\u1eddng h\u01b0\u01a1ng v\u1ecb, che b\u1edbt v\u1ecb kh\u00f3 ch\u1ecbu c\u1ee7a ho\u1ea1t ch\u1ea5t.<\/li>\n<li>Hi\u1ec7p \u0111\u1ed3ng v\u1ecb ng\u1ecdt khi ph\u1ed1i h\u1ee3p v\u1edbi acesulfam kali.<\/li>\n<li>Kh\u00e1c nhi\u1ec1u ch\u1ea5t ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao, aspartam \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a n\u00ean c\u00f3 n\u0103ng l\u01b0\u1ee3ng (kho\u1ea3ng 17 kJ\/g), nh\u01b0ng v\u1edbi l\u01b0\u1ee3ng d\u00f9ng r\u1ea5t nh\u1ecf th\u00ec \u0111\u00f3ng g\u00f3p n\u0103ng l\u01b0\u1ee3ng kh\u00f4ng \u0111\u00e1ng k\u1ec3.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t k\u1ebft tinh tr\u1eafng ng\u00e0, g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i, v\u1ecb r\u1ea5t ng\u1ecdt.<\/li>\n<li>pH dung d\u1ecbch 0,8%: 4,5\u20136,0; nhi\u1ec7t \u0111\u1ed9 n\u00f3ng ch\u1ea3y 246\u2013247 \u00b0C.<\/li>\n<li>\u0110\u1ed9 tan: h\u01a1i tan trong n\u01b0\u1edbc, kho\u1ea3ng 1% \u1edf 20 \u00b0C t\u1ea1i \u0111i\u1ec3m \u0111\u1eb3ng \u0111i\u1ec7n (pH 5,2); t\u0103ng khi nhi\u1ec7t \u0111\u1ed9 cao h\u01a1n v\u00e0 pH acid h\u01a1n (kho\u1ea3ng 10% \u1edf pH 2); kh\u00f3 tan trong ethanol.<\/li>\n<li>T\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,5\u20130,7 g\/cm\u00b3 (lo\u1ea1i h\u1ea1t), 0,2\u20130,4 g\/cm\u00b3 (lo\u1ea1i b\u1ed9t); ch\u1ec9 s\u1ed1 Carr kho\u1ea3ng 44% \u2013 lo\u1ea1i b\u1ed9t tr\u01a1n ch\u1ea3y k\u00e9m.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<ul>\n<li>B\u1ec1n \u1edf \u0111i\u1ec1u ki\u1ec7n kh\u00f4. Khi c\u00f3 \u1ea9m b\u1ecb th\u1ee7y ph\u00e2n th\u00e0nh L-aspartyl-L-phenylalanin v\u00e0 diketopiperazin (3-benzyl-6-carboxymethyl-2,5-diketopiperazin); ngo\u00e0i ra c\u00f3 \u03b2-aspartam.<\/li>\n<li>\u0110\u1ed9 b\u1ec1n trong dung d\u1ecbch ph\u1ee5 thu\u1ed9c m\u1ea1nh v\u00e0o pH (b\u1ec1n nh\u1ea5t trong v\u00f9ng acid nh\u1eb9 kho\u1ea3ng pH 4\u20135); cyclodextrin ho\u1eb7c PEG 400 (\u1edf pH 2) c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n \u0111\u1ed9 b\u1ec1n.<\/li>\n<li>Ph\u00e2n h\u1ee7y khi gia nhi\u1ec7t k\u00e9o d\u00e0i \u2013 n\u00ean d\u00f9ng quy tr\u00ecnh nhi\u1ec7t cao th\u1eddi gian ng\u1eafn r\u1ed3i l\u00e0m ngu\u1ed9i nhanh. \u1ede nhi\u1ec7t \u0111\u1ed9 cao aspartam c\u00f3 th\u1ec3 g\u00e2y h\u00f3a n\u00e2u.<\/li>\n<li>B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/li>\n<\/ul>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>Nghi\u00ean c\u1ee9u nhi\u1ec7t l\u01b0\u1ee3ng qu\u00e9t vi sai cho th\u1ea5y aspartam t\u01b0\u01a1ng k\u1ef5 v\u1edbi <strong>dicalci phosphat<\/strong> v\u00e0 <strong>magnesi stearat<\/strong> \u2013 hai t\u00e1 d\u01b0\u1ee3c r\u1ea5t ph\u1ed5 bi\u1ebfn trong vi\u00ean n\u00e9n d\u1eadp th\u1eb3ng. Aspartam c\u0169ng c\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng v\u1edbi c\u00e1c polyol (\u0111\u01b0\u1eddng alcol).<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Gh\u00e9p L-phenylalanin (ho\u1eb7c methyl ester c\u1ee7a n\u00f3) v\u1edbi acid L-aspartic b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p h\u00f3a h\u1ecdc ho\u1eb7c enzym. Ph\u01b0\u01a1ng ph\u00e1p h\u00f3a h\u1ecdc t\u1ea1o c\u1ea3 \u03b1-aspartam (ng\u1ecdt) v\u00e0 \u03b2-aspartam (kh\u00f4ng ng\u1ecdt) c\u1ea7n t\u00e1ch; ph\u01b0\u01a1ng ph\u00e1p enzym ch\u1ec9 t\u1ea1o \u03b1-aspartam.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>Aspartam \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c \u1edf m\u1ee9c s\u1eed d\u1ee5ng th\u00f4ng th\u01b0\u1eddng. Khi chuy\u1ec3n h\u00f3a t\u1ea1o methanol, acid aspartic v\u00e0 phenylalanin; ch\u1ec9 phenylalanin c\u00f3 l\u01b0\u1ee3ng \u0111\u00e1ng k\u1ec3 \u2013 v\u00f4 h\u1ea1i v\u1edbi ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh nh\u01b0ng <strong>ng\u01b0\u1eddi m\u1eafc phenylceton ni\u1ec7u (PKU) c\u1ea7n tr\u00e1nh ho\u1eb7c h\u1ea1n ch\u1ebf<\/strong>, v\u00ec v\u1eady nh\u00e3n s\u1ea3n ph\u1ea9m ch\u1ee9a aspartam th\u01b0\u1eddng c\u00f3 c\u1ea3nh b\u00e1o. WHO \u0111\u1eb7t ADI c\u1ee7a aspartam \u0111\u1ebfn 40 mg\/kg th\u1ec3 tr\u1ecdng v\u00e0 c\u1ee7a t\u1ea1p diketopiperazin \u0111\u1ebfn 7,5 mg\/kg. Khi thao t\u00e1c c\u1ea7n gi\u1ea3m thi\u1ec3u nguy c\u01a1 n\u1ed5 b\u1ee5i, d\u00f9ng k\u00ednh b\u1ea3o h\u1ed9.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>FDA x\u1ebfp nh\u00f3m GRAS; c\u00f3 trong FDA Inactive Ingredients Guide (b\u1ed9t pha u\u1ed1ng, mi\u1ebfng d\u00e1n ni\u00eam m\u1ea1c m\u00e1, c\u1ed1m, vi\u00ean bao phim, vi\u00ean n\u00e9n).<\/li>\n<li>\u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E951); c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> alitam, acesulfam kali, sucralose, natri saccharin.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Aspartame<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Aspartam (Aspartame, E951) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao Aspartam (aspartame, APM, E951) l\u00e0 dipeptid methyl ester c\u1ee7a acid L-aspartic v\u00e0 L-phenylalanin, ng\u1ecdt g\u1ea5p kho\u1ea3ng 180\u2013200 l\u1ea7n saccarose. Aspartam \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o ng\u1ecdt trong vi\u00ean n\u00e9n, thu\u1ed1c b\u1ed9t pha, ch\u1ebf ph\u1ea9m vitamin, \u0111\u1ed3 u\u1ed1ng v\u00e0 th\u1ef1c ph\u1ea9m. Th\u00f4ng tin nhanh T\u00ean kh\u00e1c [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2167,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2168","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aspartam.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aspartam-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aspartam-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aspartam-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aspartam-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aspartam.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aspartam.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aspartam-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Aspartam (Aspartame, E951) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao Aspartam (aspartame, APM, E951) l\u00e0 dipeptid methyl ester c\u1ee7a acid L-aspartic v\u00e0 L-phenylalanin, ng\u1ecdt g\u1ea5p kho\u1ea3ng 180\u2013200 l\u1ea7n saccarose. Aspartam \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o ng\u1ecdt trong vi\u00ean n\u00e9n, thu\u1ed1c b\u1ed9t pha, ch\u1ebf ph\u1ea9m vitamin, \u0111\u1ed3 u\u1ed1ng v\u00e0 th\u1ef1c ph\u1ea9m. Th\u00f4ng tin nhanh T\u00ean kh\u00e1c&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2168","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2168"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2168\/revisions"}],"predecessor-version":[{"id":2818,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2168\/revisions\/2818"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2167"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2168"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2168"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2168"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}