{"id":2149,"date":"2026-09-27T10:33:24","date_gmt":"2026-09-27T03:33:24","guid":{"rendered":"https:\/\/cpc1.vn\/polyester-aliphatic-pla-plga\/"},"modified":"2026-09-28T21:23:12","modified_gmt":"2026-09-28T14:23:12","slug":"polyester-aliphatic-pla-plga","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/polyester-aliphatic-pla-plga\/","title":{"rendered":"Polyester aliphatic (PLA, PGA, PLGA, PCL) \u2013 polyme ph\u00e2n h\u1ee7y sinh h\u1ecdc"},"content":{"rendered":"

Polyester aliphatic (PLA, PGA, PLGA, PCL) \u2013 polyme ph\u00e2n h\u1ee7y sinh h\u1ecdc<\/h1>\n

Polyester aliphatic<\/strong> l\u00e0 nh\u00f3m polyme t\u1ed5ng h\u1ee3p ph\u00e2n h\u1ee7y sinh h\u1ecdc, g\u1ed3m poly(lactid) (PLA), poly(glycolid) (PGA), \u0111\u1ed3ng tr\u00f9ng h\u1ee3p lactid\u2013glycolid (PLGA) v\u00e0 poly-\u03b5-caprolacton (PCL). \u0110\u00e2y l\u00e0 n\u1ec1n t\u1ea3ng c\u1ee7a ph\u1ea7n l\u1edbn c\u00e1c h\u1ec7 thu\u1ed1c ti\u00eam v\u00e0 c\u1ea5y gh\u00e9p gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i hi\u1ec7n nay.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
C\u00e1c lo\u1ea1i ch\u00ednh<\/td>\nD-PLA, L-PLA, DL-PLA; PGA; L-PLGA v\u00e0 DL-PLGA (t\u1ef7 l\u1ec7 lactid:glycolid 85:15 \u0111\u1ebfn 50:50); PCL; DL-PLCL<\/td>\n<\/tr>\n
S\u1ed1 CAS ti\u00eau bi\u1ec3u<\/td>\nPLA 26680-10-4 \/ 26161-42-2 (t\u00f9y \u0111\u1ed3ng ph\u00e2n); PGA 26124-68-5; PLGA 26780-50-7 \/ 30846-39-0; PCL 24980-41-4<\/td>\n<\/tr>\n
Kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed<\/td>\nT\u1eeb kho\u1ea3ng 2.000 \u0111\u1ebfn tr\u00ean 100.000<\/td>\n<\/tr>\n
T\u00ean th\u01b0\u01a1ng m\u1ea1i<\/td>\nLactel, Medisorb, Purasorb, Resomer\u2026<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nV\u1eadt li\u1ec7u ph\u00e2n h\u1ee7y sinh h\u1ecdc, t\u01b0\u01a1ng h\u1ee3p sinh h\u1ecdc, t\u1ef1 ti\u00eau<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

C\u01a1 ch\u1ebf ph\u00e2n h\u1ee7y<\/h2>\n

Trong m\u00f4i tr\u01b0\u1eddng n\u01b0\u1edbc, li\u00ean k\u1ebft ester b\u1ecb th\u1ee7y ph\u00e2n, t\u1ea1o ra c\u00e1c acid hydroxycarboxylic kh\u00f4ng \u0111\u1ed9c (acid lactic, acid glycolic). C\u00e1c acid n\u00e0y \u0111i v\u00e0o chu tr\u00ecnh acid citric v\u00e0 cu\u1ed1i c\u00f9ng chuy\u1ec3n th\u00e0nh CO2<\/sub> v\u00e0 n\u01b0\u1edbc. Nh\u1edd \u0111\u00f3 polyme “t\u1ef1 bi\u1ebfn m\u1ea5t” sau khi \u0111\u00e3 gi\u1ea3i ph\u00f3ng h\u1ebft ho\u1ea1t ch\u1ea5t.<\/p>\n

\u1ee8ng d\u1ee5ng trong b\u00e0o ch\u1ebf<\/h2>\n
    \n
  • H\u1ec7 c\u1ea5y gh\u00e9p<\/strong>: que, tr\u1ee5, \u1ed1ng, m\u00e0ng, s\u1ee3i, pellet, h\u1ea1t.<\/li>\n
  • H\u1ec7 ti\u00eam<\/strong>: vi nang, vi c\u1ea7u, nano h\u1ea1t v\u00e0 h\u1ec7 l\u1ecfng t\u1ea1o kh\u1ed1i t\u1ea1i ch\u1ed7 gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t \u2013 d\u00f9ng cho ng\u01b0\u1eddi v\u00e0 th\u00fa y.<\/li>\n
  • V\u1eadt li\u1ec7u y khoa: v\u00edt, \u0111inh, que c\u1ed1 \u0111\u1ecbnh.<\/li>\n<\/ul>\n

    T\u1ed1c \u0111\u1ed9 ph\u00e2n h\u1ee7y v\u00e0 gi\u1ea3i ph\u00f3ng ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c “tinh ch\u1ec9nh” qua \u0111\u1ed9 k\u1ebft tinh, t\u00ednh k\u1ef5 n\u01b0\u1edbc, c\u1ea5u h\u00ecnh l\u1eadp th\u1ec3 monome (L hay DL), t\u1ef7 l\u1ec7 \u0111\u1ed3ng tr\u00f9ng h\u1ee3p v\u00e0 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed. V\u00ed d\u1ee5: PLGA 50:50 v\u00f4 \u0111\u1ecbnh h\u00ecnh ph\u00e2n h\u1ee7y nhanh h\u01a1n L-PLA k\u1ebft tinh.<\/p>\n

    T\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • M\u00e0u tr\u1eafng \u0111\u1ebfn v\u00e0ng nh\u1ea1t; PLA \u0111\u1ed3ng ph\u00e2n DL v\u00e0 PLGA \u1edf d\u1ea1ng v\u00f4 \u0111\u1ecbnh h\u00ecnh, L-PLA v\u00e0 PGA k\u1ebft tinh.<\/li>\n
    • PGA k\u1ebft tinh ch\u1ec9 tan trong dung m\u00f4i m\u1ea1nh nh\u01b0 hexafluoroisopropanol; L-PLA k\u1ebft tinh c\u0169ng kh\u00f3 tan.<\/li>\n
    • DL-PLA v\u00f4 \u0111\u1ecbnh h\u00ecnh v\u00e0 PLGA \u00edt glycolid tan t\u1ed1t trong methylen clorid, THF, ethyl acetat, aceton, cloroform \u2013 thu\u1eadn l\u1ee3i cho k\u1ef9 thu\u1eadt b\u1ed1c h\u01a1i dung m\u00f4i khi b\u00e0o ch\u1ebf vi c\u1ea7u.<\/li>\n
    • R\u1ea5t \u00edt tan ho\u1eb7c kh\u00f4ng tan trong n\u01b0\u1edbc, methanol, ethylen glycol, heptan, hexan.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      R\u1ea5t d\u1ec5 th\u1ee7y ph\u00e2n khi c\u00f3 \u1ea9m, v\u00ec v\u1eady n\u00ean b\u1ea3o qu\u1ea3n l\u1ea1nh, t\u1ed1t nh\u1ea5t d\u01b0\u1edbi 0 \u00b0C. \u0110\u1ec3 bao b\u00ec v\u1ec1 nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng tr\u01b0\u1edbc khi m\u1edf (tr\u00e1nh ng\u01b0ng t\u1ee5 h\u01a1i n\u01b0\u1edbc). Sau khi m\u1edf, n\u00ean th\u1ed5i l\u1ea1i nit\u01a1 kh\u00f4 tinh khi\u1ebft tr\u01b0\u1edbc khi \u0111\u00f3ng k\u00edn.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5 v\u00e0 thao t\u00e1c<\/h2>\n

      Khi g\u1eb7p \u1ea9m, polyme sinh ra acid (acid lactic, acid hydroxyacetic) n\u00ean tr\u00e1nh ti\u1ebfp x\u00fac v\u1edbi c\u00e1c ch\u1ea5t ph\u1ea3n \u1ee9ng v\u1edbi acid, nh\u1ea5t l\u00e0 trong \u0111i\u1ec1u ki\u1ec7n \u1ea9m. Tr\u00e1nh \u0111\u1ec3 b\u1ee5i polyme ti\u1ebfp x\u00fac m\u1eaft, da v\u00e0 tr\u00e1nh h\u00edt ph\u1ea3i.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      C\u00e1c polyester n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p b\u1eb1ng tr\u00f9ng h\u1ee3p m\u1edf v\u00f2ng c\u00e1c dimer v\u00f2ng (lactid, glycolid) ho\u1eb7c \u03b5-caprolacton, v\u1edbi ch\u1ea5t x\u00fac t\u00e1c v\u00e0 \u0111i\u1ec1u ki\u1ec7n ki\u1ec3m so\u00e1t \u0111\u1ec3 \u0111\u1ea1t kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed v\u00e0 t\u1ef7 l\u1ec7 monome mong mu\u1ed1n.<\/p>\n

      An to\u00e0n<\/h2>\n

      PLA, PGA, PLGA v\u00e0 PCL \u0111\u01b0\u1ee3c d\u00f9ng trong thu\u1ed1c ti\u00eam, \u0111\u01b0\u1ee3c xem l\u00e0 v\u1eadt li\u1ec7u ph\u00e2n h\u1ee7y sinh h\u1ecdc, t\u01b0\u01a1ng h\u1ee3p sinh h\u1ecdc v\u00e0 t\u1ef1 ti\u00eau; s\u1ea3n ph\u1ea9m ph\u00e2n h\u1ee7y kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng g\u00e2y ung th\u01b0, kh\u00f4ng g\u00e2y qu\u00e1i thai.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • \u0110\u01b0\u1ee3c li\u1ec7t k\u00ea GRAS; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> acid lactic.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Aliphatic Polyesters<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Polyester aliphatic (PLA, PGA, PLGA, PCL) \u2013 polyme ph\u00e2n h\u1ee7y sinh h\u1ecdc Polyester aliphatic l\u00e0 nh\u00f3m polyme t\u1ed5ng h\u1ee3p ph\u00e2n h\u1ee7y sinh h\u1ecdc, g\u1ed3m poly(lactid) (PLA), poly(glycolid) (PGA), \u0111\u1ed3ng tr\u00f9ng h\u1ee3p lactid\u2013glycolid (PLGA) v\u00e0 poly-\u03b5-caprolacton (PCL). \u0110\u00e2y l\u00e0 n\u1ec1n t\u1ea3ng c\u1ee7a ph\u1ea7n l\u1edbn c\u00e1c h\u1ec7 thu\u1ed1c ti\u00eam v\u00e0 c\u1ea5y gh\u00e9p gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i hi\u1ec7n […]<\/p>","protected":false},"author":1,"featured_media":2148,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2149","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyester-aliphatic-pla-plga.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyester-aliphatic-pla-plga-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyester-aliphatic-pla-plga-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyester-aliphatic-pla-plga-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyester-aliphatic-pla-plga-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyester-aliphatic-pla-plga.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyester-aliphatic-pla-plga.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyester-aliphatic-pla-plga-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Polyester aliphatic (PLA, PGA, PLGA, PCL) \u2013 polyme ph\u00e2n h\u1ee7y sinh h\u1ecdc Polyester aliphatic l\u00e0 nh\u00f3m polyme t\u1ed5ng h\u1ee3p ph\u00e2n h\u1ee7y sinh h\u1ecdc, g\u1ed3m poly(lactid) (PLA), poly(glycolid) (PGA), \u0111\u1ed3ng tr\u00f9ng h\u1ee3p lactid\u2013glycolid (PLGA) v\u00e0 poly-\u03b5-caprolacton (PCL). \u0110\u00e2y l\u00e0 n\u1ec1n t\u1ea3ng c\u1ee7a ph\u1ea7n l\u1edbn c\u00e1c h\u1ec7 thu\u1ed1c ti\u00eam v\u00e0 c\u1ea5y gh\u00e9p gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i hi\u1ec7n…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2149"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2149\/revisions"}],"predecessor-version":[{"id":3349,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2149\/revisions\/3349"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2148"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}