{"id":2143,"date":"2026-09-27T10:33:00","date_gmt":"2026-09-27T03:33:00","guid":{"rendered":"https:\/\/cpc1.vn\/alpha-tocopherol\/"},"modified":"2026-09-28T21:04:07","modified_gmt":"2026-09-28T14:04:07","slug":"alpha-tocopherol","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/alpha-tocopherol\/","title":{"rendered":"Alpha tocopherol (vitamin E) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a trong b\u00e0o ch\u1ebf"},"content":{"rendered":"

Alpha tocopherol (vitamin E) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a trong b\u00e0o ch\u1ebf<\/h1>\n

Alpha tocopherol<\/strong> \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn ch\u1ee7 y\u1ebfu l\u00e0 m\u1ed9t d\u1ea1ng vitamin E, nh\u01b0ng trong b\u00e0o ch\u1ebf n\u00f3 c\u00f2n l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a tan trong d\u1ea7u<\/strong> quan tr\u1ecdng cho c\u00e1c ch\u1ebf ph\u1ea9m d\u1ea7u, m\u1ee1, \u0111\u1ed3ng th\u1eddi l\u00e0 dung m\u00f4i th\u00e2n d\u1ea7u t\u1ed1t cho nhi\u1ec1u ho\u1ea1t ch\u1ea5t kh\u00f3 tan.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\ndl-\u03b1-tocopherol, all-rac-\u03b1-tocopherol, alpha tocopherol t\u1ed5ng h\u1ee3p, E307, 5,7,8-trimethyltocol<\/td>\n<\/tr>\n
T\u00ean h\u00f3a h\u1ecdc<\/td>\n(\u00b1)-(2RS,4’RS,8’RS)-2,5,7,8-Tetramethyl-2-(4′,8′,12′-trimethyltridecyl)-6-chromanol<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n10191-41-0 (dl); 59-02-9 (d-\u03b1-tocopherol t\u1ef1 nhi\u00ean)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC29<\/sub>H50<\/sub>O2<\/sub> \u2013 430,72<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ch\u1ed1ng oxy h\u00f3a (\u0111\u1ed3ng th\u1eddi l\u00e0 m\u1ed9t vitamin)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Ph\u00e2n t\u1eed c\u00f3 3 trung t\u00e2m b\u1ea5t \u0111\u1ed1i n\u00ean c\u00f3 8 \u0111\u1ed3ng ph\u00e2n. D\u1ea1ng t\u1ef1 nhi\u00ean l\u00e0 d-\u03b1-tocopherol (2R,4’R,8’R); d\u1ea1ng t\u1ed5ng h\u1ee3p dl-\u03b1-tocopherol l\u00e0 h\u1ed7n h\u1ee3p racemic c\u1ee7a c\u1ea3 8 \u0111\u1ed3ng ph\u00e2n v\u1edbi l\u01b0\u1ee3ng b\u1eb1ng nhau.<\/p>\n

\u1ee8ng d\u1ee5ng trong b\u00e0o ch\u1ebf<\/h2>\n
    \n
  • Antioxidant protection<\/strong> cho ch\u1ebf ph\u1ea9m d\u1ea7u ho\u1eb7c ch\u1ea5t b\u00e9o, n\u1ed3ng \u0111\u1ed9 th\u01b0\u1eddng d\u00f9ng 0,001\u20130,05%<\/strong> (tt\/tt).<\/li>\n
  • Th\u01b0\u1eddng c\u00f3 m\u1ed9t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u01b0u: \u1edf n\u1ed3ng \u0111\u1ed9 th\u1ea5p alpha tocopherol l\u00e0m ch\u1eadm s\u1ef1 t\u1ef1 oxy h\u00f3a c\u1ee7a acid linoleic, nh\u01b0ng \u1edf n\u1ed3ng \u0111\u1ed9 cao l\u1ea1i c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh n\u00e0y.<\/li>\n
  • Hi\u1ec7u qu\u1ea3 t\u0103ng khi ph\u1ed1i h\u1ee3p c\u00e1c ch\u1ea5t hi\u1ec7p \u0111\u1ed3ng tan trong d\u1ea7u nh\u01b0 lecithin v\u00e0 ascorbyl palmitat.<\/li>\n
  • Dung m\u00f4i th\u00e2n d\u1ea7u cho ho\u1ea1t ch\u1ea5t k\u00e9m tan; d-\u03b1-tocopherol c\u00f2n \u0111\u01b0\u1ee3c d\u00f9ng nh\u01b0 ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion h\u00f3a trong thu\u1ed1c u\u1ed1ng v\u00e0 thu\u1ed1c ti\u00eam (v\u00ed d\u1ee5 d\u1ea1ng TPGS).<\/li>\n<\/ul>\n

    X\u00e9t ri\u00eang kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a, beta, gamma v\u00e0 delta tocopherol \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ea1nh h\u01a1n alpha tocopherol.<\/p>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t l\u1ecfng d\u1ea1ng d\u1ea7u s\u00e1nh, trong, kh\u00f4ng m\u00e0u \u0111\u1ebfn v\u00e0ng n\u00e2u.<\/li>\n
    • T\u1ef7 tr\u1ecdng 0,947\u20130,951 g\/cm\u00b3; chi\u1ebft su\u1ea5t nD<\/sub>20<\/sup> = 1,503\u20131,507.<\/li>\n
    • Nhi\u1ec7t \u0111\u1ed9 s\u00f4i 235 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 240 \u00b0C.<\/li>\n
    • H\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc; d\u1ec5 tan trong aceton, ethanol, ether v\u00e0 d\u1ea7u th\u1ef1c v\u1eadt.<\/li>\n<\/ul>\n

      C\u00e1c d\u1eabn ch\u1ea5t li\u00ean quan<\/h2>\n\n\n\n\n\n\n\n
      Ch\u1ea5t<\/th>\nCAS<\/th>\n\u0110\u1eb7c \u0111i\u1ec3m<\/th>\n<\/tr>\n<\/thead>\n
      d-\u03b1-Tocopherol<\/td>\n59-02-9<\/td>\nD\u1ea1ng t\u1ef1 nhi\u00ean; d\u1ea7u v\u00e0ng ho\u1eb7c v\u00e0ng l\u1ee5c<\/td>\n<\/tr>\n
      d-\u03b1-Tocopheryl acetat<\/td>\n58-95-7<\/td>\nC31<\/sub>H52<\/sub>O3<\/sub>, 472,73; c\u00f3 th\u1ec3 \u0111\u00f4ng \u0111\u1eb7c khi l\u1ea1nh (kho\u1ea3ng 28 \u00b0C)<\/td>\n<\/tr>\n
      dl-\u03b1-Tocopheryl acetat, succinat; \u03b2-, \u03b3-, \u03b4-tocopherol<\/td>\n\u2014<\/td>\nEster b\u1ec1n v\u1edbi oxy h\u00f3a h\u01a1n nh\u01b0ng v\u00ec th\u1ebf k\u00e9m hi\u1ec7u qu\u1ea3 ch\u1ed1ng oxy h\u00f3a h\u01a1n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      L\u01b0u \u00fd: USP g\u1ecdi chung “vitamin E” cho c\u00e1c d\u1ea1ng d\/dl-\u03b1-tocopherol, acetat v\u00e0 acid succinat; Ph.Eur. t\u00e1ch th\u00e0nh chuy\u00ean lu\u1eadn ri\u00eang cho alpha tocopherol v\u00e0 alpha tocopheryl acetat.<\/p>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      Tocopherol b\u1ecb oxy h\u00f3a ch\u1eadm b\u1edfi oxy kh\u00f4ng kh\u00ed v\u00e0 nhanh b\u1edfi mu\u1ed1i s\u1eaft (III), mu\u1ed1i b\u1ea1c; s\u1ea3n ph\u1ea9m oxy h\u00f3a g\u1ed3m tocopheroxid, tocopherylquinon, tocopherylhydroquinon v\u00e0 c\u00e1c dimer, trimer. B\u1ea3o qu\u1ea3n d\u01b0\u1edbi kh\u00ed tr\u01a1, trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi peroxid v\u00e0 ion kim lo\u1ea1i, \u0111\u1eb7c bi\u1ec7t s\u1eaft, \u0111\u1ed3ng, b\u1ea1c. Tocopherol c\u00f3 th\u1ec3 b\u1ecb h\u1ea5p ph\u1ee5 v\u00e0o bao b\u00ec nh\u1ef1a.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Tocopherol t\u1ef1 nhi\u00ean \u0111\u01b0\u1ee3c chi\u1ebft ho\u1eb7c ch\u01b0ng c\u1ea5t ph\u00e2n t\u1eed t\u1eeb s\u1ea3n ph\u1ea9m ch\u01b0ng c\u1ea5t h\u01a1i n\u01b0\u1edbc c\u1ee7a d\u1ea7u th\u1ef1c v\u1eadt (d\u1ea7u ng\u00f4, c\u1ea3i d\u1ea7u, \u0111\u1eadu n\u00e0nh, h\u01b0\u1edbng d\u01b0\u01a1ng, m\u1ea7m l\u00faa m\u00ec ch\u1ee9a kho\u1ea3ng 0,1\u20130,3% alpha tocopherol). D\u1ea1ng t\u1ed5ng h\u1ee3p racemic \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ebf b\u1eb1ng ng\u01b0ng t\u1ee5 hydroquinon methyl h\u00f3a v\u1edbi isophytol racemic.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      Tocopherol c\u00f3 s\u1eb5n trong nhi\u1ec1u th\u1ef1c ph\u1ea9m; l\u01b0\u1ee3ng d\u00f9ng l\u00e0m ch\u1ea5t ch\u1ed1ng oxy h\u00f3a trong thu\u1ed1c v\u00e0 th\u1ef1c ph\u1ea9m r\u1ea5t nh\u1ecf so v\u1edbi l\u01b0\u1ee3ng \u0103n v\u00e0o h\u1eb1ng ng\u00e0y n\u00ean kh\u00f3 g\u00e2y h\u1ea1i. D\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng qu\u00e1 nhi\u1ec1u c\u00f3 th\u1ec3 g\u00e2y \u0111au \u0111\u1ea7u, m\u1ec7t m\u1ecfi, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a, bu\u1ed3n n\u00f4n; ti\u1ebfp x\u00fac da k\u00e9o d\u00e0i c\u00f3 th\u1ec3 g\u00e2y ban \u0111\u1ecf, vi\u00eam da ti\u1ebfp x\u00fac. WHO \u0111\u1eb7t ADI c\u1ee7a tocopherol d\u00f9ng l\u00e0m ch\u1ea5t ch\u1ed1ng oxy h\u00f3a \u1edf m\u1ee9c 0,15\u20132,0 mg\/kg th\u1ec3 tr\u1ecdng. N\u00ean d\u00f9ng g\u0103ng tay v\u00e0 k\u00ednh khi thao t\u00e1c.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • FDA x\u1ebfp nh\u00f3m GRAS; c\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch, b\u1ed9t \u0111\u00f4ng kh\u00f4 cho h\u1ed7n d\u1ecbch liposome, vi\u00ean nang, vi\u00ean n\u00e9n u\u1ed1ng, ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i).<\/li>\n
      • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E307).<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur., USP v\u00e0 c\u00e1c d\u01b0\u1ee3c \u0111i\u1ec3n kh\u00e1c.<\/li>\n<\/ul>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Alpha Tocopherol<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Alpha tocopherol (vitamin E) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a trong b\u00e0o ch\u1ebf Alpha tocopherol \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn ch\u1ee7 y\u1ebfu l\u00e0 m\u1ed9t d\u1ea1ng vitamin E, nh\u01b0ng trong b\u00e0o ch\u1ebf n\u00f3 c\u00f2n l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a tan trong d\u1ea7u quan tr\u1ecdng cho c\u00e1c ch\u1ebf ph\u1ea9m d\u1ea7u, m\u1ee1, \u0111\u1ed3ng th\u1eddi l\u00e0 dung m\u00f4i th\u00e2n d\u1ea7u t\u1ed1t cho […]<\/p>","protected":false},"author":1,"featured_media":2142,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2143","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alpha-tocopherol.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alpha-tocopherol-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alpha-tocopherol-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alpha-tocopherol-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alpha-tocopherol-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alpha-tocopherol.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alpha-tocopherol.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alpha-tocopherol-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Alpha tocopherol (vitamin E) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a trong b\u00e0o ch\u1ebf Alpha tocopherol \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn ch\u1ee7 y\u1ebfu l\u00e0 m\u1ed9t d\u1ea1ng vitamin E, nh\u01b0ng trong b\u00e0o ch\u1ebf n\u00f3 c\u00f2n l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a tan trong d\u1ea7u quan tr\u1ecdng cho c\u00e1c ch\u1ebf ph\u1ea9m d\u1ea7u, m\u1ee1, \u0111\u1ed3ng th\u1eddi l\u00e0 dung m\u00f4i th\u00e2n d\u1ea7u t\u1ed1t cho…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2143"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2143\/revisions"}],"predecessor-version":[{"id":3141,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2143\/revisions\/3141"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2142"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}