{"id":2141,"date":"2026-09-27T10:32:52","date_gmt":"2026-09-27T03:32:52","guid":{"rendered":"https:\/\/cpc1.vn\/alitam\/"},"modified":"2026-09-27T10:32:52","modified_gmt":"2026-09-27T03:32:52","slug":"alitam","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/alitam\/","title":{"rendered":"Alitam (Alitame) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt ng\u1ecdt g\u1ea5p 2000 l\u1ea7n \u0111\u01b0\u1eddng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Alitam (Alitame) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt ng\u1ecdt g\u1ea5p 2000 l\u1ea7n \u0111\u01b0\u1eddng<\/h1>\n<p><strong>Alitam<\/strong> (alitame, Aclame) l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt dipeptid \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ea7u th\u1eadp ni\u00ean 1980, ng\u1ecdt g\u1ea5p kho\u1ea3ng <strong>2000 l\u1ea7n saccarose<\/strong> v\u00e0 g\u1ea7n nh\u01b0 kh\u00f4ng cung c\u1ea5p n\u0103ng l\u01b0\u1ee3ng (kho\u1ea3ng 6 kJ\/g). Alitam hi\u1ec7n \u0111\u01b0\u1ee3c d\u00f9ng ch\u1ee7 y\u1ebfu trong th\u1ef1c ph\u1ea9m v\u00e0 \u0111\u1ed3 u\u1ed1ng.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Aclame; L-aspartyl-D-alanin-N-(2,2,4,4-tetramethylthietan-3-yl)amid<\/td>\n<\/tr>\n<tr>\n<td>T\u00ean h\u00f3a h\u1ecdc<\/td>\n<td>L-\u03b1-Aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamid<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>80863-62-3 (khan); 99016-42-9 (hydrat)<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>14<\/sub>H<sub>25<\/sub>N<sub>3<\/sub>O<sub>4<\/sub>S \u2013 331,44 (khan); d\u1ea1ng hydrat 2,5 H<sub>2<\/sub>O \u2013 376,50<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Sweeteners<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<p>Alitam \u0111\u01b0\u1ee3c d\u00f9ng trong nhi\u1ec1u lo\u1ea1i th\u1ef1c ph\u1ea9m v\u00e0 \u0111\u1ed3 u\u1ed1ng \u1edf m\u1ee9c t\u1ed1i \u0111a kho\u1ea3ng 40\u2013300 mg\/kg. V\u1edbi c\u01b0\u1eddng \u0111\u1ed9 ng\u1ecdt r\u1ea5t cao, l\u01b0\u1ee3ng d\u00f9ng c\u1ef1c nh\u1ecf; v\u1ec1 nguy\u00ean t\u1eafc c\u00f3 th\u1ec3 \u1ee9ng d\u1ee5ng l\u00e0m ch\u1ea5t t\u1ea1o ng\u1ecdt trong ch\u1ebf ph\u1ea9m u\u1ed1ng \u1edf nh\u1eefng th\u1ecb tr\u01b0\u1eddng cho ph\u00e9p.<\/p>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t k\u1ebft tinh tr\u1eafng, kh\u00f4ng h\u00fat \u1ea9m, kh\u00f4ng m\u00f9i ho\u1eb7c m\u00f9i \u0111\u1eb7c tr\u01b0ng nh\u1eb9.<\/li>\n<li>pH dung d\u1ecbch 5%: 5\u20136; \u0111i\u1ec3m \u0111\u1eb3ng \u0111i\u1ec7n pH 5,6.<\/li>\n<li>Nhi\u1ec7t \u0111\u1ed9 n\u00f3ng ch\u1ea3y 136\u2013147 \u00b0C.<\/li>\n<li>\u0110\u1ed9 tan (25 \u00b0C): kho\u1ea3ng 1\/7,6 trong n\u01b0\u1edbc (t\u0103ng nhanh theo nhi\u1ec7t \u0111\u1ed9: 1\/2,0 \u1edf 50 \u00b0C); r\u1ea5t d\u1ec5 tan trong ethanol (1\/1,6), propylen glycol (1\/1,9) v\u00e0 methanol (1\/2,4); g\u1ea7n nh\u01b0 kh\u00f4ng tan trong heptan, r\u1ea5t \u00edt tan trong cloroform.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>Alitam b\u1ec1n \u1edf \u0111i\u1ec1u ki\u1ec7n kh\u00f4, nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng nh\u01b0ng b\u1ecb ph\u00e2n h\u1ee7y khi nhi\u1ec7t \u0111\u1ed9 cao ho\u1eb7c trong dung d\u1ecbch pH th\u1ea5p. Ph\u00e2n h\u1ee7y theo m\u1ed9t b\u01b0\u1edbc (\u0111i\u1ec1u ki\u1ec7n kh\u1eafc nghi\u1ec7t) ho\u1eb7c hai b\u01b0\u1edbc ch\u1eadm \u2013 qua \u0111\u1ed3ng ph\u00e2n \u03b2-aspartic \u2013 t\u1ea1o acid aspartic v\u00e0 alanin amid. \u1ede 23 \u00b0C, th\u1eddi gian b\u00e1n h\u1ee7y c\u1ee7a dung d\u1ecbch kho\u1ea3ng 4 n\u0103m \u1edf pH 5\u20138 v\u00e0 kho\u1ea3ng 1 n\u0103m \u1edf pH 2. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, tr\u00e1nh n\u1eafng v\u00e0 nhi\u1ec7t \u0111\u1ed9 cao.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>C\u00f3 th\u1ec3 t\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a, ch\u1ea5t kh\u1eed, acid v\u00e0 base m\u1ea1nh.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Alitam \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p theo nhi\u1ec1u con \u0111\u01b0\u1eddng. M\u1ed9t c\u00e1ch l\u00e0 cho 3-(D-alaninamido)-2,2,4,4-tetramethylthietan ph\u1ea3n \u1ee9ng v\u1edbi N-thiocarboxyanhydrid c\u1ee7a acid L-aspartic, t\u00e1ch d\u01b0\u1edbi d\u1ea1ng mu\u1ed1i p-toluensulfonat r\u1ed3i chuy\u1ec3n v\u1ec1 alitam b\u1eb1ng nh\u1ef1a trao \u0111\u1ed5i anion l\u1ecfng. C\u00e1ch kh\u00e1c l\u00e0 ng\u01b0ng t\u1ee5 tetramethylthietan amin v\u1edbi D-alanin \u0111\u01b0\u1ee3c b\u1ea3o v\u1ec7, r\u1ed3i gh\u00e9p v\u1edbi d\u1eabn ch\u1ea5t b\u1ea3o v\u1ec7 c\u1ee7a acid L-aspartic v\u00e0 tinh ch\u1ebf.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>Alitam \u0111\u01b0\u1ee3c xem l\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i kh\u00f4ng \u0111\u1ed9c v\u00e0 kh\u00f4ng k\u00edch \u1ee9ng. Nghi\u00ean c\u1ee9u d\u00e0i h\u1ea1n (\u00edt nh\u1ea5t 18 th\u00e1ng) tr\u00ean chu\u1ed9t nh\u1eaft, chu\u1ed9t c\u1ed1ng v\u00e0 ch\u00f3 \u1edf li\u1ec1u tr\u00ean 100 mg\/kg\/ng\u00e0y kh\u00f4ng th\u1ea5y \u0111\u1ed9c t\u00ednh hay nguy c\u01a1 ung th\u01b0. Kho\u1ea3ng 7\u201322% li\u1ec1u u\u1ed1ng kh\u00f4ng h\u1ea5p thu; ph\u1ea7n c\u00f2n l\u1ea1i b\u1ecb th\u1ee7y ph\u00e2n th\u00e0nh acid aspartic (chuy\u1ec3n h\u00f3a b\u00ecnh th\u01b0\u1eddng) v\u00e0 alanin amid (th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u). WHO \u0111\u1eb7t ADI \u0111\u1ebfn 0,1 mg\/kg th\u1ec3 tr\u1ecdng. Khi thao t\u00e1c n\u00ean d\u00f9ng k\u00ednh v\u00e0 g\u0103ng tay.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<p>\u0110\u01b0\u1ee3c ph\u00e9p d\u00f9ng trong th\u1ef1c ph\u1ea9m t\u1ea1i m\u1ed9t s\u1ed1 n\u01b0\u1edbc nh\u01b0 \u00dac, New Zealand, Chile, Trung Qu\u1ed1c, Mexico (theo th\u00f4ng tin n\u0103m 2006). C\u1ea7n ki\u1ec3m tra quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh c\u1ee7a th\u1ecb tr\u01b0\u1eddng \u0111\u00edch tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/p>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> acesulfam kali, aspartam, saccharin, natri saccharin, natri cyclamat.<\/p>\n<h2>Nguy\u00ean li\u1ec7u t\u1ea1i CPC1<\/h2>\n<p>CPC1 \u0111ang cung c\u1ea5p c\u00e1c nguy\u00ean li\u1ec7u li\u00ean quan d\u01b0\u1edbi \u0111\u00e2y. Li\u00ean h\u1ec7 \u0111\u1ec3 nh\u1eadn COA v\u00e0 b\u00e1o gi\u00e1 theo l\u00f4 h\u00e0ng hi\u1ec7n c\u00f3.<\/p>\n<ul>\n<li><a href=\"https:\/\/cpc1.vn\/en\/san-pham\/nguyen-lieu-aspartame-powder\/\">Aspartame Powder<\/a><\/li>\n<li><a href=\"https:\/\/cpc1.vn\/en\/san-pham\/nguyen-lieu-sucralose-qingdao\/\">Sucralose (Qingdao)<\/a><\/li>\n<\/ul>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Alitame<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Alitam (Alitame) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt ng\u1ecdt g\u1ea5p 2000 l\u1ea7n \u0111\u01b0\u1eddng Alitam (alitame, Aclame) l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt dipeptid \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ea7u th\u1eadp ni\u00ean 1980, ng\u1ecdt g\u1ea5p kho\u1ea3ng 2000 l\u1ea7n saccarose v\u00e0 g\u1ea7n nh\u01b0 kh\u00f4ng cung c\u1ea5p n\u0103ng l\u01b0\u1ee3ng (kho\u1ea3ng 6 kJ\/g). Alitam hi\u1ec7n \u0111\u01b0\u1ee3c d\u00f9ng ch\u1ee7 y\u1ebfu trong th\u1ef1c ph\u1ea9m v\u00e0 \u0111\u1ed3 u\u1ed1ng. [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2140,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2141","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alitam.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alitam-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alitam-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alitam-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alitam-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alitam.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alitam.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alitam-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Alitam (Alitame) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt ng\u1ecdt g\u1ea5p 2000 l\u1ea7n \u0111\u01b0\u1eddng Alitam (alitame, Aclame) l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt dipeptid \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ea7u th\u1eadp ni\u00ean 1980, ng\u1ecdt g\u1ea5p kho\u1ea3ng 2000 l\u1ea7n saccarose v\u00e0 g\u1ea7n nh\u01b0 kh\u00f4ng cung c\u1ea5p n\u0103ng l\u01b0\u1ee3ng (kho\u1ea3ng 6 kJ\/g). Alitam hi\u1ec7n \u0111\u01b0\u1ee3c d\u00f9ng ch\u1ee7 y\u1ebfu trong th\u1ef1c ph\u1ea9m v\u00e0 \u0111\u1ed3 u\u1ed1ng.&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2141"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2141\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2140"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}