{"id":2139,"date":"2026-09-27T10:32:44","date_gmt":"2026-09-27T03:32:44","guid":{"rendered":"https:\/\/cpc1.vn\/albumin\/"},"modified":"2026-09-28T21:03:26","modified_gmt":"2026-09-28T14:03:26","slug":"albumin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/albumin\/","title":{"rendered":"Albumin \u2013 t\u00e1 d\u01b0\u1ee3c \u1ed5n \u0111\u1ecbnh protein trong thu\u1ed1c ti\u00eam"},"content":{"rendered":"

Albumin \u2013 t\u00e1 d\u01b0\u1ee3c \u1ed5n \u0111\u1ecbnh protein trong thu\u1ed1c ti\u00eam<\/h1>\n

Albumin<\/strong> (albumin huy\u1ebft thanh ng\u01b0\u1eddi, human serum albumin) l\u00e0 protein chi\u1ebfm kho\u1ea3ng 60% t\u1ed5ng protein huy\u1ebft t\u01b0\u01a1ng. Trong b\u00e0o ch\u1ebf, albumin ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c \u1ed5n \u0111\u1ecbnh cho c\u00e1c thu\u1ed1c ti\u00eam ch\u1ee9a protein v\u00e0 enzym.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nHuman serum albumin, plasma albumin, albumin human solution; m\u1ed9t s\u1ed1 t\u00ean th\u01b0\u01a1ng m\u1ea1i: Albuminar, Albutein, Buminate, Plasbumin<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n9048-49-1 (serum albumin)<\/td>\n<\/tr>\n
C\u1ea5u tr\u00fac<\/td>\nM\u1ed9t chu\u1ed7i polypeptid 585 acid amin, KLPT kho\u1ea3ng 66.500; 7 c\u1ea7u disulfid; kho\u1ea3ng 55% xo\u1eafn \u03b1; kh\u00f4ng ch\u1ee9a th\u00e0nh ph\u1ea7n carbohydrat<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t \u1ed5n \u0111\u1ecbnh (ngo\u00e0i ra l\u00e0 m\u1ed9t thu\u1ed1c d\u1ea1ng d\u1ecbch truy\u1ec1n)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng trong b\u00e0o ch\u1ebf<\/h2>\n
    \n
  • \u1ed4n \u0111\u1ecbnh protein v\u00e0 enzym trong thu\u1ed1c ti\u00eam<\/strong> \u2013 n\u1ed3ng \u0111\u1ed9 th\u01b0\u1eddng d\u00f9ng 1\u20135%, c\u00f3 c\u00f4ng th\u1ee9c d\u00f9ng th\u1ea5p \u0111\u1ebfn 0,003%.<\/li>\n
  • Ch\u1ea5t b\u1ea3o v\u1ec7 khi \u0111\u00f4ng kh\u00f4 (cryoprotectant).<\/li>\n
  • Ng\u0103n c\u00e1c protein kh\u00e1c h\u1ea5p ph\u1ee5 l\u00ean b\u1ec1 m\u1eb7t bao b\u00ec, d\u1ee5ng c\u1ee5.<\/li>\n
  • \u0110\u1ed3ng dung m\u00f4i cho m\u1ed9t s\u1ed1 thu\u1ed1c ti\u00eam.<\/li>\n
  • Nguy\u00ean li\u1ec7u b\u00e0o ch\u1ebf vi c\u1ea7u, vi nang trong c\u00e1c h\u1ec7 \u0111\u01b0a thu\u1ed1c th\u1eed nghi\u1ec7m.<\/li>\n<\/ul>\n

    Ngo\u00e0i vai tr\u00f2 t\u00e1 d\u01b0\u1ee3c, dung d\u1ecbch albumin c\u00f2n l\u00e0 m\u1ed9t thu\u1ed1c d\u1ecbch truy\u1ec1n d\u00f9ng \u0111\u1ec3 b\u00f9 th\u1ec3 t\u00edch huy\u1ebft t\u01b0\u01a1ng \u2013 n\u1ed9i dung n\u00e0y thu\u1ed9c ph\u1ea1m vi chuy\u00ean m\u00f4n l\u00e2m s\u00e0ng, kh\u00f4ng tr\u00ecnh b\u00e0y \u1edf \u0111\u00e2y.<\/p>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • USP m\u00f4 t\u1ea3 albumin ng\u01b0\u1eddi l\u00e0 ch\u1ebf ph\u1ea9m v\u00f4 khu\u1ea9n, kh\u00f4ng ch\u1ee9a ch\u1ea5t g\u00e2y s\u1ed1t, d\u1ea1ng dung d\u1ecbch 4, 5, 20 ho\u1eb7c 25 g\/100 mL; albumin chi\u1ebfm \u00edt nh\u1ea5t 96% t\u1ed5ng protein. Ph.Eur. c\u00f3 d\u1ea1ng \u0111\u1eadm \u0111\u1eb7c (150\u2013250 g\/L) v\u00e0 d\u1ea1ng \u0111\u1eb3ng tr\u01b0\u01a1ng (35\u201350 g\/L), albumin \u2265 95%.<\/li>\n
    • Kh\u00f4ng th\u00eam ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n; c\u00f3 th\u1ec3 ch\u1ee9a ch\u1ea5t \u1ed5n \u0111\u1ecbnh nhi\u1ec7t nh\u01b0 natri caprylat v\u00e0\/ho\u1eb7c N-acetyltryptophan.<\/li>\n
    • Dung d\u1ecbch h\u01a1i nh\u1edbt, g\u1ea7n nh\u01b0 kh\u00f4ng m\u00e0u \u0111\u1ebfn m\u00e0u h\u1ed5 ph\u00e1ch t\u00f9y n\u1ed3ng \u0111\u1ed9; d\u1ea1ng r\u1eafn l\u00e0 m\u1ea3nh, v\u1ea3y ho\u1eb7c b\u1ed9t v\u00f4 \u0111\u1ecbnh h\u00ecnh m\u00e0u n\u00e2u.<\/li>\n
    • pH dung d\u1ecbch 1% trong NaCl 0,9%: 6,7\u20137,3. Dung d\u1ecbch 4\u20135% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh.<\/li>\n
    • R\u1ea5t d\u1ec5 tan trong n\u01b0\u1edbc v\u00e0 dung d\u1ecbch mu\u1ed1i lo\u00e3ng; c\u00f3 th\u1ec3 pha dung d\u1ecbch 40% \u1edf pH 7,4. \u1ede pH sinh l\u00fd, ph\u00e2n t\u1eed mang \u0111i\u1ec7n t\u00edch \u00e2m kho\u1ea3ng \u221217.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      L\u00e0 protein n\u00ean albumin d\u1ec5 b\u1ecb ph\u00e2n h\u1ee7y h\u00f3a h\u1ecdc v\u00e0 bi\u1ebfn t\u00ednh khi g\u1eb7p pH qu\u00e1 cao\/th\u1ea5p, n\u1ed3ng \u0111\u1ed9 mu\u1ed1i cao, nhi\u1ec7t, enzym, dung m\u00f4i h\u1eefu c\u01a1 v\u00e0 c\u00e1c t\u00e1c nh\u00e2n h\u00f3a h\u1ecdc kh\u00e1c. Dung d\u1ecbch c\u1ea7n tr\u00e1nh \u00e1nh s\u00e1ng, b\u1ea3o qu\u1ea3n \u1edf 2\u201325 \u00b0C ho\u1eb7c theo nh\u00e3n.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      C\u00e1c y\u1ebfu t\u1ed1 g\u00e2y bi\u1ebfn t\u00ednh n\u00eau tr\u00ean (pH kh\u1eafc nghi\u1ec7t, mu\u1ed1i \u0111\u1eadm \u0111\u1eb7c, nhi\u1ec7t, enzym, dung m\u00f4i h\u1eefu c\u01a1).<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Albumin \u0111\u01b0\u1ee3c t\u00e1ch ph\u00e2n \u0111o\u1ea1n t\u1eeb m\u00e1u, huy\u1ebft t\u01b0\u01a1ng, huy\u1ebft thanh ho\u1eb7c nhau thai c\u1ee7a ng\u01b0\u1eddi hi\u1ebfn kh\u1ecfe m\u1ea1nh \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e9t nghi\u1ec7m. Theo Ph.Eur., dung d\u1ecbch \u0111\u01b0\u1ee3c l\u1ecdc qua m\u00e0ng gi\u1eef vi khu\u1ea9n, \u0111\u00f3ng v\u00f4 khu\u1ea9n, r\u1ed3i gia nhi\u1ec7t trong bao b\u00ec cu\u1ed1i \u1edf 60 \u00b0C trong \u00edt nh\u1ea5t 10 gi\u1edd v\u00e0 \u1ee7 theo d\u00f5i nhi\u1ec5m khu\u1ea9n (30\u201332 \u00b0C trong 14 ng\u00e0y ho\u1eb7c 20\u201325 \u00b0C trong 4 tu\u1ea7n). Tr\u00ean th\u1ecb tr\u01b0\u1eddng c\u0169ng c\u00f3 albumin ngu\u1ed3n \u0111\u1ed9ng v\u1eadt nh\u01b0 albumin huy\u1ebft thanh b\u00f2 (BSA).<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      L\u00e0 th\u00e0nh ph\u1ea7n t\u1ef1 nhi\u00ean c\u1ee7a c\u01a1 th\u1ec3, albumin d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c thu\u1ed1c ti\u00eam \u0111\u01b0\u1ee3c xem l\u00e0 g\u1ea7n nh\u01b0 kh\u00f4ng \u0111\u1ed9c v\u00e0 kh\u00f4ng k\u00edch \u1ee9ng. Ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i khi truy\u1ec1n albumin hi\u1ebfm g\u1eb7p, g\u1ed3m bu\u1ed3n n\u00f4n, n\u00f4n, s\u1ed1t, \u1edbn l\u1ea1nh, m\u00e0y \u0111ay; c\u00f3 th\u1ec3 x\u1ea3y ra ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng k\u1ec3 c\u1ea3 s\u1ed1c ph\u1ea3n v\u1ec7. Thao t\u00e1c theo quy \u0111\u1ecbnh d\u00e0nh cho ch\u1ebf ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb m\u00e1u.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • C\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c u\u1ed1ng, vi\u00ean n\u00e9n, m\u00e0ng bao; thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch).<\/li>\n
      • C\u00f3 trong thu\u1ed1c ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP.<\/li>\n<\/ul>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Albumin<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Albumin \u2013 t\u00e1 d\u01b0\u1ee3c \u1ed5n \u0111\u1ecbnh protein trong thu\u1ed1c ti\u00eam Albumin (albumin huy\u1ebft thanh ng\u01b0\u1eddi, human serum albumin) l\u00e0 protein chi\u1ebfm kho\u1ea3ng 60% t\u1ed5ng protein huy\u1ebft t\u01b0\u01a1ng. Trong b\u00e0o ch\u1ebf, albumin ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c \u1ed5n \u0111\u1ecbnh cho c\u00e1c thu\u1ed1c ti\u00eam ch\u1ee9a protein v\u00e0 enzym. Th\u00f4ng tin nhanh T\u00ean kh\u00e1c Human serum […]<\/p>","protected":false},"author":1,"featured_media":2138,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2139","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/albumin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/albumin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/albumin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/albumin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/albumin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/albumin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/albumin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/albumin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Albumin \u2013 t\u00e1 d\u01b0\u1ee3c \u1ed5n \u0111\u1ecbnh protein trong thu\u1ed1c ti\u00eam Albumin (albumin huy\u1ebft thanh ng\u01b0\u1eddi, human serum albumin) l\u00e0 protein chi\u1ebfm kho\u1ea3ng 60% t\u1ed5ng protein huy\u1ebft t\u01b0\u01a1ng. Trong b\u00e0o ch\u1ebf, albumin ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c \u1ed5n \u0111\u1ecbnh cho c\u00e1c thu\u1ed1c ti\u00eam ch\u1ee9a protein v\u00e0 enzym. Th\u00f4ng tin nhanh T\u00ean kh\u00e1c Human serum…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2139","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2139"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2139\/revisions"}],"predecessor-version":[{"id":3133,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2139\/revisions\/3133"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2138"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2139"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2139"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}